O1‐01‐06: Walnuts‐rich diet improves memory deficits and learning skills in transgenic mouse model of Alzheimer's disease

Scope: Decreasing β-amyloid (Aβ) accumulation is of significance in finding therapeutic candidates for cognitive impairments in Alzheimer's disease (AD). The aim of this study is to investigate the potency of the active components of walnut protein in decreasing Aβ aggregation and ameliorating cognitive impairments. Methods and results: Cell model of intracellular Aβ42 aggregation is used to explore the active ingredients in walnut protein hydrolysate (WPH). A bioactive peptide (Pro-Pro-Lys-Asn-Trp, PW5) with great anti-Aβ42 aggregation activity identified from the WPH is synthesized for in vitro and in vivo experiments. Using classic APP/PS1 mouse model, it is validated that PW5 exerts its effects on cognitive improvement through reducing Aβ plaques accumulation. Moreover, metabolomic analysis reveals that serum norepinephrine (NE) and isovalerate levels are significantly increased in response to PW5 intervention, with decreased serum levels of acetylcholine (AChe) and valerate, compared with the vehicle-treated APP/PS1 mice. PW5 feeding also improves gut dysbiosis in APP/PS1 transgenic mice by increasing the relative abundance of Firmicutes and decreasing Proteobacteria and Verrucomicrobia as displayed by 16s rRNA analyses. Conclusions: These promising results support the utilization of peptide PW5 as an active ingredient in functional foods or potential drug candidate for the prevention and/or treatment of AD.

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“…Abha et al. found that walnut‐rich diet improves memory deficits and learning skills in Tg2576 AD mouse model . Muthaiyah et al.…”

Section: Discussionmentioning

confidence: 99%

Walnut‐Derived Peptide PW5 Ameliorates Cognitive Impairments and Alters Gut Microbiota in APP/PS1 Transgenic Mice

Wang

Amakye

Guo

et al. 2019

Molecular Nutrition Food Res

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“…Similarly, in an investigation by Gunduc and El [102], they demonstrated that the kernel of J. regia L. contains the highest content of total phenolic compounds and antioxidant activity among 25 types of commonly consumed foods. It has been reported that the regular and adequate consumption of the walnut seed is associated with the reduction of the risk of some diseases such as cancer [20,103], cardiovascular symptoms [104,105,106,107,108,109,110,111,112,113,114,115,116], diabetes [117], and degenerative disorders [118,119]. Different parts of the walnut tree and its fruit, including the green husk as epicarp or mesocarp, hard shell of the nut (endocarp), dividing membranes of the kernel (pellicle), flower, root, trunk (bark and wood), branch, and leaf are comprehensively considered in order to use for different purposes.…”

Section: The Health Benefits Of Walnutsmentioning

confidence: 99%

A Comprehensive Review on the Chemical Constituents and Functional Uses of Walnut (Juglans spp.) Husk

Jahanban-Esfahlan

Ostadrahimi

Tabibiazar

et al. 2019

IJMS

157

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The walnut (Juglans spp.) is an appreciated nut that belongs to the Juglandaceae family. The fruit includes four main parts: the kernel, the skin, the shell, and the green husk. It is widely cultivated due to its edible kernel. In walnut production centers, high amounts of the husk as an agro-forest waste product are produced and discarded away. Recently, it has been demonstrated that the walnut green husk could be valued as a source of different natural bioactive compounds with excellent antioxidant and antimicrobial properties. Regarding this respect, in this contribution, the current scientific knowledge on the antioxidant and antiradical activities, various identified and isolated individual chemical constituents, as well as the functional applications of the walnut husk with more emphasis on the Persian walnut (Juglans regia L.) are reviewed.

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Walnut (Juglans regiaL.) shell pyroligneous acid: chemical constituents and functional applications

Jahanban-Esfahlan

Amarowicz

2018

RSC Adv.

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Upon the processing of different agricultural products, considerable amounts of by-products and biowastes are produced and discarded or burnt as fuel, which are a potential source of valuable compounds. Over the past several decades, plant by-products have been recognized as a source of nutraceutical components, including dietary fibers, phenolics, and many other useful compounds. The walnut is known as an important tree nut. The shell of a walnut is the middle part of the fruit and it is a waste product of walnut processing industries. Recently, pyroligneous acids from the walnut shell have been receiving much-increasing interest because of their excellent antimicrobial and antioxidant activities. Hence, this review deals with the recent scientific literature on walnut shell pyroligneous acids and their chemical composition as well as their functional applications.a Collected at three temperature ranges by GC-MS. b Collected at seven temperature ranges by GC-MS. c 5% NaHCO 3 extract (OA 5 ) and 4% NaOH extract (P 3 ).This journal is a Collected at three temperature ranges by GC-MS. b Collected at seven temperature ranges by GC-MS. c 5% NaHCO 3 extract (OA 5 ) and 4% NaOH extract (P 3 ). Fig. 2 The chemical structures of organic acids identified in walnut shell pyroligneous acids.This journal is a Collected at three temperature ranges by GC-MS. b Collected at seven temperature ranges by GC-MS. c 5% NaHCO 3 extract (OA 5 ) and 4% NaOH extract (P 3 ).22382 | RSC Adv., 2018,8,[22376][22377][22378][22379][22380][22381][22382][22383][22384][22385][22386][22387][22388][22389][22390][22391] This journal is a Collected at three temperature ranges by GC-MS. b Collected at seven temperature ranges by GC-MS. c 5% NaHCO 3 extract (OA 5 ) and 4% NaOH extract (P 3 ).

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O1‐01‐06: Walnuts‐rich diet improves memory deficits and learning skills in transgenic mouse model of Alzheimer's disease

Cited by 4 publications

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Walnut‐Derived Peptide PW5 Ameliorates Cognitive Impairments and Alters Gut Microbiota in APP/PS1 Transgenic Mice

Walnut‐Derived Peptide PW5 Ameliorates Cognitive Impairments and Alters Gut Microbiota in APP/PS1 Transgenic Mice

A Comprehensive Review on the Chemical Constituents and Functional Uses of Walnut (Juglans spp.) Husk

Walnut (Juglans regiaL.) shell pyroligneous acid: chemical constituents and functional applications

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