O30 The epidemiology of antiphospholipid syndrome in the UK, 1990-2016

Antiphospholipid syndrome in rural, remote, and First Nations peoples in the Top End of the Northern Territory, Australia

“…The estimated incidence of APS is approximately 1 to 5 new cases per 100,000 person-years, with a prevalence of 6 to 50 per 100,000 persons (depending on ethnicity), female predominance, and 85% of patients being young- to middle-aged (15-50 years of age) [ 1 , 3 , 21 , 22 ]. Our findings compare to data from a large UK population–based study reporting a 4.1:1 ratio of females to males in cases and a peak incidence of APS in women of 7.5 new cases per 100,000 person-years at an age of 35 to 39 years and a peak incidence of APS in men of 2 new cases per 100,000 person-years at an age of 55 to 59 years [ 25 ]. These data compare to a large population-based Korean study ( n = 3088 incident cases over 10 years), in which new incident cases of APS were observed at a mean age of 44.6 ± 16.6 years, with a bimodal peak incidence among women at ages 30 to 39 and 70 to 79 years and a single peak in men at 70 to 79 years [ 22 ].…”

Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION): 10-Year Update

“…Based on population studies, APS meets the definition of a rare disease as described by Holué (prevalence ≤5 per 10,000 population) [31], with the reported prevalence 1.7-5 per 10,000 population [4,5,32]. However, based on our systematic reviews discussed above [6][7][8] and other prospective studies [33,34] the true prevalence of APS is difficult to calculate given the lack of large-scale well-designed population studies, and the relatively common challenge of APS underdiagnosis and overdiagnosis.…”

Trophoblast Cell Function in the Antiphospholipid Syndrome

“…Secondary APS represents coexistence of APS with some other autoimmune disorder, usually systemic lupus erythematosus (SLE) [1,4]. APS/SLE patients account for around 30% of all APS cases [5][6][7][8].…”

“…The estimated APS annual incidence and prevalence in the general population ranges between 1 and 2 cases per 100,000 persons and between 40 and 50 per 100,000 persons, respectively [9]. Most of the APS patients are diagnosed during the reproductive period with the mean age of diagnosis between 30 and 40 years for women, as several studies presented [6,[8][9][10][11]. Moreover, APS is found to be more frequent in females especially when considering patients with secondary APS associated with SLE [6,9,10].…”

“…Most of the APS patients are diagnosed during the reproductive period with the mean age of diagnosis between 30 and 40 years for women, as several studies presented [6,[8][9][10][11]. Moreover, APS is found to be more frequent in females especially when considering patients with secondary APS associated with SLE [6,9,10]. However, some studies found that there was no difference in APS frequency between sexes [7][8][9].…”