O4–04–03: Amnestic mild cognitive impairment in a referral population—a non–progressing subgroup exists on long–term follow–up

Chertkow, Howard; Bergman, Howard; Bocti, Christian; McKelvey, Roger; Phillips, Natalie; Whitehead, Victor

doi:10.1016/j.jalz.2006.05.320

Cited by 2 publications

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“…4,5 According to several works, 6,7 cognitive training has been found to have a protective role in older adults and mainly those who are at risk of developing dementia. Moreover, Chertkow et al, (2006) 8 supported that structured intervention in MCI can reverse and prevent dementia onset through improvement of daily functionality.…”

Section: Introductionmentioning

confidence: 93%

Longitudinal Cognitive and Physical Training Effectiveness in MCI, Based on the Experience of the Alzheimer’s Hellas Day Care Centre

Poptsi

Tsatali

Agogiatou

et al. 2021

J Geriatr Psychiatry Neurol

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This study assesses the effectiveness of a multicomponent Longitudinal Cognitive Training (CT) program plus physical exercise (PE) for people with Mild Cognitive Impairment (MCI). 155 people with MCI, completed a 3 years (3Y) CT+PE, whilst 133 were control. Neuropsychological assessment was performed at baseline and 3 years later, whilst CT+PE had additional annual assessments. According to the results, the 3Y CT+PE outperformed control in cognitive abilities ( p < 0.002), and Activities of Daily Living (ADL) ( p < 0.001), stabilized their functional performances between 1st and 2nd year, but worsened in working and verbal memory between 2nd and 3 rd year ( p < 0.002). Control deteriorated in cognitive functions ( p < 0.001) and ADL ( p < 0.001) after 3 years, whilst 1.33% of the experimental and 13.53% of the control group progressed to dementia ( p < 0.001). Longitudinal CT+PE improves cognitive performance and ADL in MCI and delay the progression to dementia.

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Section: Introductionmentioning

confidence: 93%

Longitudinal Cognitive and Physical Training Effectiveness in MCI, Based on the Experience of the Alzheimer’s Hellas Day Care Centre

Poptsi

Tsatali

Agogiatou

et al. 2021

J Geriatr Psychiatry Neurol

View full text Add to dashboard Cite

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“…Indeed, 10% to 15% of the individuals with MCI will progress to dementia each year, compared to an annual rate of 1% to 2% in the general population over 65 years old [ 1 ]. Ultimately, in most memory clinics, between 50% and 75% of patients presenting with MCI will go on to dementia over long term follow-up [ 2 , 3 ]. MCI individuals often show hippocampal atrophy, a characteristic feature of Alzheimer’s disease (AD), to a degree midway between that of normal individuals and demented patients [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Word reading threshold and mild cognitive impairment: a validation study

2012

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BackgroundIt was previously found, in a pilot study, that Word Reading Threshold (WRT) test is abnormally prolonged in individuals with Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI), with high sensitivity and specificity. This validation study examines the WRT test as a prognostic tool in MCI individuals. We wish to confirm in a larger group the sensitivity and specificity of the WRT test and determine whether it is influenced by deterioration on other cognitive domains.MethodsWe measured WRT in 60 MCI individuals, 29 AD patients, and 33 normal elderly control (NE). We followed the MCI individuals over 8 years to monitor who progressed to dementia.ResultsWe found a statistically significant difference in WRT scores between the three groups. However, using the same cutoff of 85 milliseconds suggested by Massoud and his colleagues, we found lower diagnostic sensitivity (72%) and specificity (76%) when comparing NC and AD. Furthermore, the test did not clearly differentiate MCI individuals who progressed to dementia from those who did not. WRT was found to correlate to some degree with other cognitive domains, especially attention.ConclusionsWe conclude that the WRT is insufficient alone as a diagnostic tool for prodromal AD.

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O4–04–03: Amnestic mild cognitive impairment in a referral population—a non–progressing subgroup exists on long–term follow–up

Cited by 2 publications

References 0 publications

Longitudinal Cognitive and Physical Training Effectiveness in MCI, Based on the Experience of the Alzheimer’s Hellas Day Care Centre

Longitudinal Cognitive and Physical Training Effectiveness in MCI, Based on the Experience of the Alzheimer’s Hellas Day Care Centre

Word reading threshold and mild cognitive impairment: a validation study

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