O486 Perinatal Outcome of 132 Pregnancies Complicated by Immune Thrombocytopenia

Jahromi, Bahia Namavar; Shiravani, Zahra; Salarian, Leila

doi:10.1016/s0020-7292(12)60916-3

Cited by 2 publications

(8 citation statements)

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“…After applying inclusion criteria, 21 studies remained-all of which were retrospective cohort studies. 18,[21][22][23][24][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] The extracted data from these studies are summarized in detail in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…The 21 studies contained data from a total of 1951 mothers and 1844 infants, including 375 infants suffering from thrombocytopenia. The average maternal age, as calculated from the 11 studies that reported this information, 21,22,24,34,36,[38][39][40]42,43,47 was 27.7 AE 2.8 years.…”

Section: Participant Informationmentioning

confidence: 99%

“…Neonatal thrombocytopenia overall incidence was assessed in all of the 21 included studies. 18,[21][22][23][24]31,[33][34][35][36][37][38][39][40][41][42][43][44][45]47 The overall event rate of all thrombocytopenia was found to be (Figure 4) 24% (95% CI = 16.7%-33.1%, p < 0.01) presenting negligible heterogeneity (I 2 : 15.3%).…”

Section: Incidence Of Thrombocytopeniamentioning

confidence: 99%

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A meta‐analysis of neonatal outcomes in pregnant women with immune thrombocytopenic purpura

Luo

Gao

et al. 2021

J of Obstet and Gynaecol

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Aim: Thrombocytopenia is an autoimmune disorder characterized by reduced platelet counts. Neonatal thrombocytopenia incidence has been linked with immune thrombocytopenic purpura in mothers during pregnancy, possibly because antiplatelet antibodies can cross the placental barrier. To date, no study has attempted to evaluate the actual prevalence of neonatal thrombocytopenia in infants born to mothers with immune thrombocytopenic purpura. In this meta-analysis of the available literature, we attempt to fill this gap. We want to evaluate the overall prevalence of neonatal thrombocytopenia, its severity, and the incidence of hemorrhage in infants with thrombocytopenia born from mothers with immune thrombocytopenic purpura. Methods: Adhering to PRISMA guidelines, we systematically scanned four academic databases including EMBASE, CENTRAL, Scopus, and MEDLINE to identify relevant literature. We performed a meta-analysis to summarize thrombocytopenia incidence rate and severity in newborn infants of mothers with immune thrombocytopenic purpura. Results: We identified 21 eligible studies involving 1951 mothers and 1844 neonates. Meta-analysis showed high prevalence for neonatal thrombocytopenia (24%). Within these, severe cases were the most prevalent (41.2%), followed by moderate (37.7%) and mild (17.6%) cases. Hemorrhage was only reported in 4.1% of the observed neonatal thrombocytopenia cases. Conclusion:This review provides preliminary evidence that neonatal thrombocytopenia incidence is high in infants born to mothers with immune thrombocytopenic purpura. This study further reports that the largest proportion of these cases are severe.

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Section: Resultsmentioning

confidence: 99%

Section: Participant Informationmentioning

confidence: 99%

Section: Incidence Of Thrombocytopeniamentioning

confidence: 99%

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A meta‐analysis of neonatal outcomes in pregnant women with immune thrombocytopenic purpura

Luo

Gao

et al. 2021

J of Obstet and Gynaecol

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“…Literature review suggests that gestational thrombocytopenia is the most common cause of pregnancy specific thrombocytopenia. [5][6][7] It may be explained by the fact that platelet count is not done in all patients in the third trimester in the center. Hence significant number of patients with gestational thrombocytopenia may not have been diagnosed.…”

Section: Discussionmentioning

confidence: 99%

“…4 A prompt intervention is required in complicated cases of thrombocytopenia to reduce maternal and perinatal morbidity and mortality. 5 This study has investigated the spectrum of causes of thrombocytopenia in pregnancy and its effect on feto -maternal outcome.…”

Section: Introductionmentioning

confidence: 99%

Low platelet counts in pregnancy: an alarm signal for abruption!

Mundkur

Nambiar

Rai

2018

Int J Reprod Contracept Obstet Gynecol

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Background: Thrombocytopenia, defined as a platelet count less than 150 million/mm3, affects 6% to 10% of all pregnant women and other than anemia is the most common hematologic disorder in pregnancy.Methods: We studied all patients with thrombocytopenia in pregnancy from June 2012 to May 2013. There were 86 patients recruited into the study. Pregnant women with preeclampsia and suspected connective tissue disorder were also screened for thrombocytopenia. All women with platelet count of <1.50,000/µl during the study period were included.Results: Patients were grouped in to mild thrombocytopenia (platelet 100,000-149,999/µl), moderate thrombocytopenia (platelet 50,000-99,999/µl) and severe thrombocytopenia (platelet <49,999/µl. Pregnancy specific cause of thrombocytopenia was in 63 (73.2%) women and non-pregnancy specific were in 23(26.7%) patients.Conclusions: Preeclampsia and HELLP syndrome is more common cause of thrombocytopenia in pregnancy. Abruption can occur in patients with severe thrombocytopenia. Though platelet count is not routinely done in pregnancy it is advisable to do so as it may help in detecting gestational thrombocytopenia or other immune related condition.

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O486 Perinatal Outcome of 132 Pregnancies Complicated by Immune Thrombocytopenia

Cited by 2 publications

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A meta‐analysis of neonatal outcomes in pregnant women with immune thrombocytopenic purpura

A meta‐analysis of neonatal outcomes in pregnant women with immune thrombocytopenic purpura

Low platelet counts in pregnancy: an alarm signal for abruption!

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