O496 Alcohol sclerosing ovarian cystic lesions, 20 years after

Kukura, Vlastimir

doi:10.1016/s0020-7292(09)60869-9

Cited by 2 publications

(4 citation statements)

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“…Kukura et al 12 have reported that 95% EST may be a feasible and practical therapeutic modality for the treatment of simple ovarian cysts in humans. These authors treated a total of 90 younger patients with controlled cyst rupture alone without EST, with a relapse rate of 24.44% (n=22) after 3 months.…”

Section: Discussionmentioning

confidence: 99%

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The effect of ethanol sclerotherapy of 5 minutes duration on cyst diameter and rat ovarian tissue in simple ovarian cysts

Şi̇mşek¹,

Kuloğlu²,

Pala³

et al. 2015

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ObjectivesTo examine the effect of 95% ethanol sclerotherapy (EST) administered over 5 minutes on cyst diameter and ovarian tissue in experimentally induced simple ovarian cysts in a rat model.Materials and methodsIn order to induce ovarian cysts, unilateral total salpingectomy was performed in regularly menstruating adult female Wistar albino rats (n=20) between 12 and 14 weeks of age and weighing between 200 and 220 g. One month after the procedure, the abdominal cavity was opened and 14 rats (70%) were found to have developed macroscopic cysts. Rats with macroscopic cysts (n=14) were assigned into two groups in a prospective and single-blinded manner: group 1 (G1) (n=7), control rats; and group 2 (G2) (n=7), 5-minute EST 95% group. Cyst diameter was measured and recorded for each rat. In G2, after whole cyst fluid was aspirated the cystic cavity was irrigated with 95% ethanol, approximately equal to half of the aspirated cyst volume, after which an interval of 5 minutes was allowed and same amount was re-aspirated and the abdominal cavity was closed. One month after this procedure, abdominal cavities were reopened and intra-abdominal adhesion scoring was performed in both groups. Cyst diameter was measured for each rat, and the right ovary was removed, fixed in 10% formaldehyde, and transported to the laboratory. A histologic assessment of the ovarian tissues was performed under light microscopy following staining with hematoxylin and eosin. Mann–Whitney U-test was used for statistical analysis. A P-level less than 0.05 was considered significant.ResultsIn comparison with G1, there was a statistically significant reduction in the mean ovarian cyst dimensions in G2, while there were no significant differences between the two groups with respect to total number of follicles. Again, a significant increase in apoptotic activity and germinal epithelial degeneration was observed in G2 as compared to G1. The two groups were similar in terms of adhesion formation.ConclusionAlthough 95% EST results in a reduction in the size of simple ovarian cysts, this effect seems to be achieved at the expense of ovarian tissue injury.

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Section: Discussionmentioning

confidence: 99%

“…Alcohol is a sclerosing agent, and following the exposure of the epithelial cell layer of the cyst to the effects of alcohol, the cyst becomes nonviable. 12 Ethanol diffuses into tissues, resulting in the induction of dehydration, protein denaturation, coagulation necrosis, and reactive fibrosis. 13 …”

Section: Introductionmentioning

confidence: 99%

The effect of ethanol sclerotherapy of 5 minutes duration on cyst diameter and rat ovarian tissue in simple ovarian cysts

Şi̇mşek¹,

Kuloğlu²,

Pala³

et al. 2015

DDDT

View full text Add to dashboard Cite

show abstract

“…We attempted to contact with two authors in order to obtain some missing data, but no response was provided. Ultimately, 20 articles published between 1990 and 2020 and reporting data on 1386 women undergoing US-guided aspiration of adnexal masses were included [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41].…”

Section: Studies Selectionmentioning

confidence: 99%

“…Ethylalcoholwas the most frequent sclerosant agent used (8 articles), while other types of agents were used in the rest (tetracycline in 3 and lauromacragol in 1). Four studies did not address their recurrence criteria [24, 33,39,41]. Of the remaining 16 articles, 10 set a fixed size by centimeters [22,25,26,29,30,31,37] or by volume [27,28,32] to define recurrence.…”

Section: Characteristics Of Studies Includedmentioning

confidence: 99%