Summary
Rectal gonorrhea and chlamydia increase the risk of a new diagnosis of HIV independent of rectal sexual behavior among men who have sex with men.
Background
Rectal sexually transmitted infections (STI) have been associated with HIV diagnosis, but inferring a causal association requires disentangling them from receptive anal intercourse (RAI).
Methods
We conducted a stratified case-control study by frequency matching 4 controls to each case within year using clinical data from men who have sex with men (MSM) attending the Seattle STD Clinic 2001–2014. Cases were MSM with a new HIV diagnosis and negative HIV test ≤12 months. Controls were HIV-negative MSM. All included men had rectal STI testing, tested negative for syphilis, and had complete sexual behavior data. We categorized men by RAI: (1) none; (2) condoms for all RAI; (3) condomless RAI (CRAI) only with HIV-negative partners; and (4) CRAI with HIV-positive or unknown-status partners. We created three logistic regression models: (1) three univariate models of concurrent rectal gonorrhea, rectal chlamydia, and rectal STI in ≤12 months with new HIV diagnosis; (2) those three infections, plus age, race, year, number of sexual partners ≤2 months, and methamphetamine use; and (3) model 2 with RAI categories. We calculated the population attributable risk of rectal STI on HIV diagnoses.
Results
Among 176 cases and 704 controls, rectal gonorrhea, chlamydia and rectal STI ≤12 months were associated with HIV diagnosis. The magnitude of these associations attenuated in the second model, but persisted in model 3 (gonorrhea aOR 2.3 95%CI 1.3 – 3.8; chlamydia aOR 2.5 95%CI 1.5 – 4.3; prior STI aOR 3.0 95%CI 1.5 – 6.2). One in 7 HIV diagnoses can be attributed to rectal STI.
Conclusion
Rectal STI are independently associated with HIV acquisition. These findings support the hypothesis that rectal STI play a biologically-mediated causal role in HIV acquisition and support screening/treatment of STI for HIV prevention.