O51. Squamous cell carcinoma of oropharynx: Influence of site of primary tumour

Pathak, Kalyani; Hajjaj, Hassan; Viallet, Nicolas; Sutherland, Dean; Kerr, Peter; Nason, Richard W.

doi:10.1016/j.oos.2009.06.136

Cited by 3 publications

(3 citation statements)

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“…The tonsils are the most common sub-site followed by the tongue base. In spite of their close proximity tongue base-SCCs, tonsil SCCs and soft palate SCCs have different clinical presentation and treatment outcomes [ 7 ]. In particular, tonsil SCCs have significantly better outcome (DSS and DFS) than tongue base SCCs [ 8 ].…”

Section: Reviewmentioning

confidence: 99%

The role of human papillomavirus in the pathogenesis of head & neck squamous cell carcinoma: an overview

Pannone

Santoro

Papagerakis

et al. 2011

Infect Agents Cancer

105

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Cancer statistics report an increased incidence of OSCC and OPSCC around the world. Though improvements in screening and early diagnosis have dramatically reduced the incidence of this neoplasm in recent years, the 5-year-disease-free survival, is still poor, specially for oropharyngeal cancer, despite the great scientific and financial efforts. Recently, several papers showed that HPV may be involved at least in the pathogenesis of a subgroup of oral and cervical SCC, leading to distinct molecular characteristics compared with HPV-negative ones. Nevertheless, OPSCCs associated with HPV infection seem to show a better prognosis and affect younger patients (< 40 yrs.), especially females. Therefore, there is the need to properly assess oropharyngeal SCC subgroups: 1) not HPV associated/classic oral SCC: less responsive to anticancer drugs: needs novel post-surgical treatment; 2) HPV associated/oral SCC: needs several management options and suitable "target" therapy against the virus, and/or immune-stimulating therapy. Further issues are: 1) the disclosure of putative targets for more efficient molecular therapy, which may work as cervical cancer post-surgical treatment, in anticipation of the effects of "global prevention" performed by WHO anti-HPV vaccination programs; 2) careful identification of precancerous lesions in both sites; dysplasia is currently treated by excisional or ablative procedures, which don't consider the concept of field carcinogenesis. In fact, it is probable that near or far from an excised precancerous lesion new foci of cell transformation may exist, which are not yet macroscopically evident, but, if detected, would put the patient into a high risk subgroup.Comparing findings reported in the recent literature, the data of this state of the art about HPV might add useful informations concerning oropharyngeal carcinogenesis. Moreover, our review would be useful in order to define novel perspectives of treatment choice for Head & Neck cancer patients, by combining well known chemotherapeutical drugs with new molecular "target" therapy.

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Section: Reviewmentioning

confidence: 99%

The role of human papillomavirus in the pathogenesis of head & neck squamous cell carcinoma: an overview

Pannone

Santoro

Papagerakis

et al. 2011

Infect Agents Cancer

105

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“…Head and neck squamous cell carcinoma accounts for roughly 8-10% of all malignancies [1]. Oral squamous cell carcinoma (OSCC) mostly affects the buccal mucosa, lip, alveolar ridge, retromolar trigone, hard palate, floor of the mouth, ventral two-thirds of the tongue, and oropharynx [2]. To minimize the mortality and morbidity of this illness, it is essential to develop ways for early identification and detection of OSCC, which will allow for appropriate intervention and treatment.…”

Section: Introductionmentioning

confidence: 99%

Salivary biomarkers for early detection of oral squamous cell carcinoma and oral potentially malignant disorders

Vasileios¹,

Dimitrios²,

Athanasios³

2023

Oral Health Care

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Aim: Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers of epithelial origin associated with high morbidity and death. The tumor markers play an increasingly vital role in the diagnosis and treatment of cancer. The aim of this review was to search for articles in English using the keywords: Saliva markers, Oral squamous cell carcinoma, and Oral potentially malignant disorder in PubMed and Google Scholar databases. Article abstracts and entire texts were evaluated.Background: Recent data suggest that the clinical and histological appearance of oral mucosa may not accurately reflect the underlying genetic alteration. This discrepancy in phenotype and genotype may explain in part for the inability to design effective screening and monitoring strategies based on conventional clinical and microscopic investigation.Review results: These laboratory-based tests may be helpful for screening for early malignancy, assisting in cancer diagnosis, assessing prognosis, surveillance after curative surgery for cancer, predicting medication response or resistance in advance, and monitoring treatment for advanced illness. Conclusion:Salivary biomarkers may have a crucial role in the early detection and successful diagnosis of oral cancer and oral potentially malignant disorders.Clinical Significance: This article may assist in the identification of possible biomarkers for screening and molecular pathology investigation in OSCC patients at high risk.

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“…[ 1 ] The primary anatomic sites of the oral squamous cell carcinoma (OSCC) are buccal mucosa, lip, alveolar ridge, retromolar trigone, hard palate, floor of the mouth, the ventral two-thirds of the tongue, and oropharynx. [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

A Review of Salivary Biomarker: A Tool for Early Oral Cancer Diagnosis

et al. 2017

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The oral squamous cell carcinoma (OSCC) is one of the most common epithelial malignancies with significant morbidity and mortality. Recent observations indicate that the clinical and histological appearance of oral mucosa may not truly depict the damage occurring at the genetic level. This phenotypic and genotypic disparity may account in part for the failure to establish effective screening and surveillance protocols, based on the traditional clinical and microscopic examination. The tumor markers are playing an increasingly important role in cancer detection and management. These laboratory-based tests are potentially useful in screening for early malignancy, aiding in cancer diagnosis, determining prognosis, surveillance following curative surgery for cancer, up-front predicting drug response or resistance, and monitoring therapy in advanced disease. A systematic review of the literature was performed based on the English titles listed in the PubMed, EBSCO, Cochrane, Science Direct, ISI web Science, and SciELO databases using the keywords. Abstracts and full-text articles were assessed. This article may help to identify the potential biomarkers for screening and the molecular pathology analysis in the high-risk patients with the OSCC.

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O51. Squamous cell carcinoma of oropharynx: Influence of site of primary tumour

Cited by 3 publications

References 0 publications

The role of human papillomavirus in the pathogenesis of head & neck squamous cell carcinoma: an overview

The role of human papillomavirus in the pathogenesis of head & neck squamous cell carcinoma: an overview

Salivary biomarkers for early detection of oral squamous cell carcinoma and oral potentially malignant disorders

A Review of Salivary Biomarker: A Tool for Early Oral Cancer Diagnosis

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