Abstract
Background: Primary localised bone lymphoma is a rare affection prevalent in humans. It often involves long bones, but can be found in all the skeleton bones. The diagnosis is based on the anatomopathological study with immunohistochemical study of a bone biopsy. Case presentation: We also report the first diagnosed case of primary bone lymphoma of the humerus since the inauguration of our university hospital (since September 2014).Conclusions: It is an extremely rare pathology, of which the orthopedist must know. Treatment is based on chemotherapy (with or without anti-CD20) followed by radiotherapy. The prognosis of primary localised bone lymphoma is very favorable.