2015
DOI: 10.1016/j.joca.2015.03.003
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OARSI Clinical Trials Recommendations: Hand imaging in clinical trials in osteoarthritis

Abstract: Tremendous advances have occurred in our understanding of the pathogenesis of hand osteoarthritis (OA) and these are beginning to be applied to trials targeted at modification of the disease course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply hand imaging assessments in disease modifying clinical trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendat… Show more

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Cited by 25 publications
(20 citation statements)
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“…Although much is known about the economic burden of hand OA in terms of the direct costs of some treatments, less is known about the indirect costs of this condition such as loss of productivity 66,67,68 . For example, in one study, arthroplasty surgery for first CMCJ OA often resulted in substantial time off work 69 .…”
Section: [H2] Individual and Societal Burdenmentioning
confidence: 99%
“…Although much is known about the economic burden of hand OA in terms of the direct costs of some treatments, less is known about the indirect costs of this condition such as loss of productivity 66,67,68 . For example, in one study, arthroplasty surgery for first CMCJ OA often resulted in substantial time off work 69 .…”
Section: [H2] Individual and Societal Burdenmentioning
confidence: 99%
“…Radiography constitutes the gold standard for diagnosis, but shows limited associations with pain and function [ 7 , 8 ]. Other methods such as magnetic resonance imaging (MRI), ultrasound and isotope scans may be more dynamic and informative with regard to individual joints and disease activity [ 9 – 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…At T0, demographic and OA-related characteristics and the number and nature of comorbidities were collected. Furthermore, postero-anterior (PA) radiographs of both hands were taken 28 and scored according to K&L and Verbruggen-Veys 29,30 . Erosive hand OA was classified as the presence of at least one joint in the E phase or the R phase.…”
Section: Clinical Parametersmentioning
confidence: 99%