Oberflächenspannung (OS) in der Lunge und Schocklunge

Benzer, H

doi:10.1007/978-3-642-85450-7_103

Cited by 2 publications

(4 citation statements)

References 2 publications

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“…33 hours point might be caused by an alteration of cellular particularly of the surfactant producing type II cells, at this time of disease. As mentioned above, a change in surfactant composition and/or surfactant production has consequences for lung function, particularly in disease [2,6,16]. The results of our experiments agree with those of [17].…”

Section: Discussionsupporting

confidence: 94%

“…We conclude from the finding, that palmitic acid incorporation into lecithin is much more depressed than that of choline, that one important mechanism might be the alteration of acyltransferase~. A alteration of surfactant substances is reported to be of great value for the development of lung disorders after trauma, shock and sepsis [1,2]. Therefore an altered synthesis of these substances may play a role, at least in part, in the pathogenesis of these lung disorders.…”

Section: Discussionmentioning

confidence: 90%

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Altered metabolism of phospholipids in the lung of rats with peritonitis

Wiegers

Stephan

et al. 1978

Res. Exp. Med.

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Pulmonary alterations after shock and sepsis, described clinically as shock lung or adult respiratory distress syndrome, are of great importance in intensive care. Pathogenetically an alteration of the surfactant system of the lung is often discussed. Since phospholipids are constituents of lung surfactants, phospholipid metabolism is investigated in experimental peritonitis in rats in our laboratory. 15 hours after inducing a peritonitis, the lung incorporates more oleic acid than that in animals of the reference group. 33 hours after inducing peritonitis, the capacity of the lung to incorporate choline and fatty acids is markedly reduced, histologically the lungs represent morphological equivalents of the so-called shock lung at this time. Therefore we conclude, that an alteration of phospholipid metabolism with a diminished and/or altered synthesis of lung surfactant plays, at least in part, an important role in the pathogenesis of respiratory distress in sepsis and peritonitis.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 90%

Altered metabolism of phospholipids in the lung of rats with peritonitis

Wiegers

Stephan

et al. 1978

Res. Exp. Med.

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“…Der Zutritt von Serumbestandteilen zerst6rt den Oberfl~ichenfilm und setzt ihn aul3er Funktion (Benzer, 1975). Ein einmal gest6rtes Surfactant-System hat eine /iberragende, vor allem in Gestalt eines Circulus vitiosus fortwirkende pathogenetische Bedeutung (Benzer, 1975).…”

Section: C) Surfactant-storungenunclassified

“…Haider u. Baum (1974) haben zeigen k6nnen, dab die Surfactant-Funktion schon relativ friJh nach dem Schockereignis beeintr~ichtigt ist. Obwohl f~ir den Menschen aus methodischen Griinden noch keine Daten tiber Produktions-und Degradationsraten der Surfactant-Substanz vorgelegt werden k6nnen und deswegen fiber eine m6gliche prim~ire Rolle des Surfactant-Systems als pathogenetisches Prinzip bei der sogenannten Schocklunge noch keine Aussage gemacht werden kann, ist aber zu mindest die sekund~ire Beteiligung des Surfactant-Systems an der Entwicklung, vor ailem aber an der Progression der sogenannten Schocklunge sicher (Bleyl, 1971;Benzer, 1975;Haider u. Baum, 1974). Ver~inderungen der oberfl~ichenaktiven Substanz und ihrer Bildung sind im Tierversuch unter Bedingungen, die denen der Klinik sehr ~ihnlich waren, wiederholt und schliissig beschrieben worden (Rubin et al, 1972;v.…”

Section: C) Surfactant-storungenunclassified

Die sogenannte Schocklunge, ein Krankheitsbild des Lungenparenchyms

Wichert

Riesner

1977

Langenbecks Arch Chiv

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Although the pathogenesis of the so-called shock lung is different, from the clinical point of view the syndrome is uniform. Regarding the morphology microcirculation, vascular permeability and surfactant of the lung in shock lung are discussed. The course of the alterations in lung parenchyma is uniform, independent of the different pathogenesis in a single case. Pathology and disturbtion of lung function are conform. The relation of the so-called shock lung to other diseases of lung parenchyma is discussed and finally a definition of the so-called shock-lung recommended.

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Oberflächenspannung (OS) in der Lunge und Schocklunge

Cited by 2 publications

References 2 publications

Altered metabolism of phospholipids in the lung of rats with peritonitis

Altered metabolism of phospholipids in the lung of rats with peritonitis

Die sogenannte Schocklunge, ein Krankheitsbild des Lungenparenchyms

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