Obese But Not Normal-Weight Women With Polycystic Ovary Syndrome Are Characterized by Metabolic and Microvascular Insulin Resistance

Comparison of metformin and N-acetylcysteine on metabolic parameters in women with polycystic ovarian syndrome

“…40 Treating 20 PCOS women, Kilicdag noticed that despite the insignificant change in fasting plasma glucose, insulin levels dropped significantly and decline in HOMA-IR was statistically significant in NAC compared with placebo. 8 On the contrary Elnashar reported significant drop in FPG and serum insulin among patients who received metformin and not in NAC group. 41 Fulghesu, assessing insulin sensitivity using colompe euglycemic hyperinsulinemic technique, showed increased sensitivity to insulin and significant decline in insulin area under curve after oral glucose tolerance test after treatment with NAC while fasting plasma glucose (FPG), fasting insulin and glucose area under the curve remained unchanged.…”

“…4,5 Furthermore, although about 70% of obese women with PCOS exhibit an exaggerated insulin secretion, this feature is also present in 20%-40% of lean PCOS. [6][7][8] Chronic hyperinsulinemia results in different pathologies such as diabetes mellitus type 2, hypertension, cardiovascular diseases and metabolic syndrome.…”

“…4,5 Furthermore, although about 70% of obese women with PCOS exhibit an exaggerated insulin secretion, this feature is also present in 20%-40% of lean PCOS. [6][7][8] Chronic hyperinsulinemia results in different pathologies such as diabetes mellitus type 2, hypertension, cardiovascular diseases and metabolic syndrome.1,9 Risk factors of cardiovascular diseases tend to accumulate in these women even at their young age and dyslipidemia in these patients is correlated with IR. [10][11][12] It has been proven ABSTRACT Background: Polycystic ovary syndrome (PCOS) is a common disease that affects up to 10% of women of reproductive age, in which hyperandrogenism (HA), enlarged cystic ovaries, and chronic anovulation often co-exist with obesity, dyslipidemia and insulin resistance (IR).…”

Relationship between Vitamin D and Insulin Resistance in Polycystic Ovary Syndrome Women

“…Nine studies reported these values also for control women. 19,20,[22][23][24]27,28,41,[45][46][47][48][49][50][51][52][53][54][55][56] The overall mean of serum …”

Medical management of clomiphene-resistant polycystic ovarian syndrome: an update

“…2,3 and in 70% of obese and 30% of thin PCOS patients, sententious insulin secretion is observed. [4][5][6] The implication of the insulin resistance and compensatory hyperinsulinemia accelerate the effect of luteinizing hormone (LH) on ovarian theca cells and androgen synthesis which in turn inhibits ovulation through cessation of the follicular maturity process. Ghrelin is a growth hormone secretagogue and actively involved in regulation of weight and appetite.…”