Obese Patients With a Binge Eating Disorder Have an Unfavorable Metabolic and Inflammatory Profile

Abstract

To evaluate whether obese patients with a binge eating disorder (BED) have an altered metabolic and inflammatory profile related to their eating behaviors compared with non-BED obese.A total of 115 White obese patients consecutively recruited underwent biochemical, anthropometrical evaluation, and a 75-g oral glucose tolerance test. Patients answered the Binge Eating Scale and were interviewed by a psychiatrist. The patients were subsequently divided into 2 groups according to diagnosis: non-BED obese (n = 85) and BED obese (n = 30). Structural equation modeling analysis was performed to elucidate the relation between eating behaviors and metabolic and inflammatory profile.BED obese exhibited significantly higher percentages of altered eating behaviors, body mass index (P < .001), waist circumference (P < .01), fat mass (P < .001), and a lower lean mass (P < .001) when compared with non-BED obese. Binge eating disorder obese also had a worse metabolic and inflammatory profile, exhibiting significantly lower high-density lipoprotein cholesterol levels (P < .05), and higher levels of glycated hemoglobin (P < .01), uric acid (P < .05), erythrocyte sedimentation rate (P < .001), high-sensitive C-reactive protein (P < .01), and white blood cell counts (P < .01). Higher fasting insulin (P < .01) and higher insulin resistance (P < .01), assessed by homeostasis model assessment index and visceral adiposity index (P < .001), were observed among BED obese. All differences remained significant after adjusting for body mass index. No significant differences in fasting plasma glucose or 2-hour postchallenge plasma glucose were found. Structural equation modeling analysis confirmed the relation between the altered eating behaviors of BED and the metabolic and inflammatory profile.Binge eating disorder obese exhibited an unfavorable metabolic and inflammatory profile, which is related to their characteristic eating habits.

Pediatric Loss of Control Eating and High-Sensitivity C-Reactive Protein Concentrations

“…Consistent with previous findings in adults with binge eating disorder, 19 we found that youth with LOC eating had significantly higher inflammation, as measured by hsCRP, than those without LOC, even after adjusting for differences in fat mass. Notably, these findings were independent of other factors that might contribute to elevated hsCRP.…”

“…Based on findings that adults with obesity and binge eating disorder have worse metabolic and inflammatory profiles compared to their counterparts with obesity, but without the disorder, 19 and that youth with reported LOC eating have worse metabolic characteristics than those without LOC eating, 26 we hypothesized that children and adolescents who reported LOC eating would have higher serum concentrations of hsCRP than youth without LOC, after adjusting for adiposity. In addition, given that past research has shown a bidirectional link between psychopathology and inflammation, [28][29][30] and that youth with LOC eating report more psychopathology than youth without LOC eating, 23,31,32 we examined whether depressive symptoms or eating-related psychopathology mediated the relationship between LOC eating and hsCRP concentration.…”

“…[14][15][16] Although the association between binge eating and obesity-related comorbid conditions may be, in large part, explained by the increased weight of those with binge eating, 14,17,18 some preliminary data suggest that even independent of adiposity, adults with obesity and binge eating disorder have worse metabolic and inflammatory profiles than adults with obesity, but without the disorder. 19 Although youth typically do not meet full criteria for binge eating disorder, loss of control (LOC) eating, the subjective experience of being unable to stop eating regardless of the amount of food consumed, is commonly reported by children and adolescents. 20 For youth, it appears that the subjective experience of LOC eating is a more salient indicator of aberrant eating than episode size.…”

Effectiveness of Multidisciplinary Intervention in Obese Women with Binge Eating Disorder

“…Differently from our study, Succurro et al [25] demonstrated an unfavorable metabolic and inflammatory profile only in obese women with BED. They studied 115 obese individuals of both genders and divided them into 2 groups per the presence or absence of binge eating.…”

Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder

“…In another study of patients with known neurodegenerative diseases, those with co-morbid binge eating disorder had greater atrophy in right-sided orbitofrontal-insular-striatal circuit and were more likely to be diagnosed with frontotemporal dementia [24]. While BED commonly occurs in normal-weight individuals, obese individuals with BED have significantly higher rates of dietary disinhibition, psychiatric comorbidities, and cognitive dysfunction [25–27] as well as higher rates of metabolic disorder and increased inflammatory markers [28]. In one study involving body weight matched overweight women, those with BED had greater risk taking behavior, reduced utilization of feedback processing, impaired decision-making and cognitive flexibility [29].…”