Obese Subjects have Significantly Higher Serum Prooxidant- Antioxidant Balance Values Compared to Normal-Weight Subjects

Razavi, Akramosadat; Baghshani, Mohammad Reza; Andalibi, Mohammad Sobhan Sheikh; Rahsepar, Amir Ali; Moohebati, Mohsen; Nematy, Mohsen; Tavallaie, Shima; Mousavi, Somayeh; Akhlaghi, Saeed; Ghayour‐Mobarhan, Majid; Ferns, Gordon A.

doi:10.7754/clin.lab.2012.120403

Cited by 10 publications

(11 citation statements)

References 12 publications

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“… 24 In this study, the obese group had a significantly higher ROS level and significantly lower SOD activity at baseline compared with the non-obese group. This result supports previous studies reporting that obese subjects show a higher pro-oxidant/antioxidant ratio compared with that of normal-weight subjects 34 and implies that obesity can increase oxidative stress. On the other hand, ROS levels decreased and SOD activity levels increased significantly in the obese group after training.…”

Section: Discussionsupporting

confidence: 92%

The effects of aerobic exercise training on oxidant–antioxidant balance, neurotrophic factor levels, and blood–brain barrier function in obese and non-obese men

Roh

2017

Journal of Sport and Health Science

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PurposeThe purpose of this study was to investigate the effects of obesity and aerobic exercise training on oxidant–antioxidant balance, neurotrophic factor levels, and blood–brain barrier (BBB) function.MethodsTen non-obese healthy men (body mass index < 25 kg/m2) and 10 obese men (body mass index ≥ 25 kg/m2) were included in the study. Both groups performed treadmill exercise for 40 min 3 times weekly for 8 weeks at 70% heart rate reserve. Blood samples were collected to examine oxidant–antioxidant balance (reactive oxygen species (ROS) and superoxide dismutase (SOD) activity levels), neurotrophic factors (brain-derived neurotrophic factor (BDNF), nerve growth factor, and glial cell line-derived neurotrophic factor levels), and BBB function (S100β and neuron-specific enolase (NSE) levels) before and after exercise training.ResultsThe obese group showed significantly greater changes than the non-obese group in serum ROS (−0.46 ± 0.31 mmol/L vs. −0.10 ± 0.17 mmol/L, p = 0.005), serum S100β levels (−8.50 ± 5.92 ng/L vs. −0.78 ± 5.45 ng/L, p = 0.007), and serum NSE levels (−0.89 ± 0.54 µg/L vs. −0.01 ± 0.74 µg/L, p = 0.007) after training. At baseline, the obese group showed significantly higher serum ROS and S100β levels and significantly lower serum SOD activity and BDNF levels than the non-obese group (p < 0.05). The obese group showed significantly lower serum ROS, S100β, and NSE levels and significantly higher serum SOD activity and BDNF levels after training compared with baseline (p < 0.05).ConclusionThese results suggest that obesity can reduce serum neurotrophic factor levels and can induce BBB dysfunction. On the other hand, aerobic exercise can improve an oxidant–antioxidant imbalance in obese subjects and limit BBB dysfunction.

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Section: Discussionsupporting

confidence: 92%

The effects of aerobic exercise training on oxidant–antioxidant balance, neurotrophic factor levels, and blood–brain barrier function in obese and non-obese men

Roh

2017

Journal of Sport and Health Science

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“…All subjects were asked to receive two treatment sessions per week for a total of 6 weeks. In previous studies, PAB values have been demonstrated to be elevated in patients with established coronary artery disease (CAD) and acute coronary syndrome (ACS)[35]. Furthermore, it has been indicated that PAB may be a potential cardiovascular risk predictor [36].…”

Section: Evidence From Clinical Studiesmentioning

confidence: 99%

Mechanisms of Acupuncture Therapy for Simple Obesity: An Evidence-Based Review of Clinical and Animal Studies on Simple Obesity

Wang

Huang

Wei

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Simple obesity is a worldwide epidemic associated with rapidly growing morbidity and mortality which imposes an enormous burden on individual and public health. As a part of Traditional Chinese Medicine (TCM), acupuncture has shown the positive efficacy in the management of simple obesity. In this article, we comprehensively review the clinical and animal studies that demonstrated the potential mechanisms of acupuncture treatment for simple obesity. Clinical studies suggested that acupuncture regulates endocrine system, promotes digestion, attenuates oxidative stress, and modulates relevant molecules of metabolism in patients of simple obesity. Evidence from laboratory indicated that acupuncture regulates lipid metabolism, modulates inflammatory responses, and promotes white adipose tissue browning. Acupuncture also suppresses appetite through regulating appetite regulatory hormones and the downstream signaling pathway. The evidence from clinical and animal studies indicates that acupuncture induces multifaceted regulation through complex mechanisms and moreover a single factor may not be enough to explain the beneficial effects against simple obesity.

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“…People suffering with obesity have increased OS and inflammation ; it has been suggested that obesity might also increase the risk of telomere shortening. The negative health effects of obesity are more relevant in those who have higher central obesity (CO), since it is associated with lower survival rate, even in subjects with normal body mass index (BMI) .…”

Section: Introductionmentioning

confidence: 99%

Effect of obesity on telomere length: Systematic review and meta-analysis

Mundstock

Sarria

Zatti

et al. 2015

Obesity

182

151

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Objective: The main objective of this systematic review is to assess the effects of obesity on telomere length. Methods: The following databases were searched: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), LILACS, SPORTdiscus, and Web of Science from inception to August 2014. The search was performed using the following combinations of terms: telomere AND "overweight" OR "obesity" OR "adiposity," without language restriction. Results: Sixty-three original studies were included in this systematic review, comprising 119,439 subjects. Thirty-nine studies showed either weak or moderate correlation between obesity and telomere length; however, they showed an important heterogeneity. Conclusions: There is a tendency toward demonstrating negative correlation between obesity and telomere length. The selected studies showed weak to moderate correlation for the main search, and there was an important heterogeneity. For this reason, the causal relationship of obesity and telomere length remains open. Additional controlled longitudinal studies are needed to investigate this issue.

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Obese Subjects have Significantly Higher Serum Prooxidant- Antioxidant Balance Values Compared to Normal-Weight Subjects

Cited by 10 publications

References 12 publications

The effects of aerobic exercise training on oxidant–antioxidant balance, neurotrophic factor levels, and blood–brain barrier function in obese and non-obese men

The effects of aerobic exercise training on oxidant–antioxidant balance, neurotrophic factor levels, and blood–brain barrier function in obese and non-obese men

Mechanisms of Acupuncture Therapy for Simple Obesity: An Evidence-Based Review of Clinical and Animal Studies on Simple Obesity

Effect of obesity on telomere length: Systematic review and meta-analysis

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