Obesity

Haslam, David; James, W. P. T.

doi:10.1016/s0140-6736(05)67483-1

Cited by 4,008 publications

(3,084 citation statements)

References 84 publications

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“…17 Obese patients tended to be younger and have more comorbidities. However, we found no association between the risk of prostate cancer recurrence and common conditions closely related to obesity, such as diabetes, 18 hypertension, 19 and heart disease. 20 Finally, prostate cancer recurrence may be related to the technical difficulties in performing optimal prostate resection and lymph node dissection in an obese patient.…”

Section: Resultscontrasting

confidence: 71%

Impact of obesity on prostate cancer recurrence after radical prostatectomy: Data from CaPSURE

Bassett

Cooperberg

Sadetsky

et al. 2005

Urology

123

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Objectives. To determine the association between obesity and prostate cancer recurrence after primary treatment with radical prostatectomy. Methods. Data were abstracted from CaPSURE, a disease registry of 10,018 men with prostate cancer. We included 2131 men who had undergone radical prostatectomy between 1989 and 2003 and had body mass index (BMI) information available. Recurrence was defined as two consecutive prostate-specific antigen (PSA) levels of 0.2 ng/mL or greater or any second treatment. Patients were risk stratified using the PSA level, Gleason grade, and clinical T stage. Results. Patients were followed up for a median of 23 months. Of the 2131 patients, 251 (12%) developed recurrence at a median of 13 months (range 1 to 107); 183 (9%) of these men had PSA failure and 68 (3%) received a second treatment. After adjusting for risk group, ethnicity, age, and comorbidities, a significant association was found between an increasing BMI and disease recurrence (P ϭ 0.028). Very obese patients (BMI 35 kg/m 2 or more) were 1.69 times more likely to have recurrence relative to men of normal weight (BMI less than 25.0 kg/m 2 ; 95% confidence interval [CI] 1.01 to 2.84). An increasing PSA level (P Ͻ0.0001) and Gleason grade (P Ͻ0.0001) were also associated with recurrence. Ethnicity was not significantly associated with either BMI or PSA recurrence (P ϭ 0.685 and P ϭ 0.068, respectively). Conclusions. The results of our study have shown that obesity is an independent predictor of prostate cancer recurrence. Because of the increased comorbidities and greater rates of recurrence, obese individuals undergoing radical prostatectomy need vigilant follow-up care. UROLOGY 66: 1060-1065, 2005.

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Section: Resultscontrasting

confidence: 71%

Impact of obesity on prostate cancer recurrence after radical prostatectomy: Data from CaPSURE

Bassett

Cooperberg

Sadetsky

et al. 2005

Urology

123

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“…[1][2][3] Comorbidities such as, for example, hypertriglyceridemia, hypercholesterolemia, low high-density lipoprotein cholesterol and type 2 diabetes increase the risk of nonfatal and fatal cardiovascular events. 4 Human obesity is defined by the body mass index of above 30, 5 and pharmacotherapy is recommended not only for obese, but also for overweight individuals (body mass index above 27) when comorbidities are present.…”

Section: Introductionmentioning

confidence: 99%

Reversal of visceral adiposity in candy-diet fed female Wistar rats by the CB1 receptor antagonist rimonabant

et al. 2008

Int J Obes

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Objective: The severity of obesity is often more determined by the distribution of fat depots rather than by body weight itself. Therefore, the effect of rimonabant on fat distribution pattern was investigated in female candy-fed Wistar rats. Design: Female Wistar rats were fed a high fat, high carbohydrate (candy-) diet for 12 weeks. During the last 6 weeks rats were treated with rimonabant. Food intake and body weight development were investigated, as well as effects on total body fat, especially visceral fat and ectopic lipid accumulation in skeletal muscle and liver, determined by in vivo magnetic resonance imaging/magnetic resonance spectroscopy. Results: Candy-diet increased body weight, which was predominantly due to the increased total fat mass with predominance of visceral fat accumulation. Treatment with rimonabant fully reversed the weight gain and fat deposition in the visceral cavity and skeletal muscle, in contrast to pair feeding. In spite of an only transient reduction of food intake, body weight reduction, as well as normalized body fat, reduced visceral fat and intramyocellular lipids were maintained over the treatment period. Conclusions: We conclude that additional factors other than reduced caloric intake must be responsible for the improvements in these lipid parameters. The complete cluster of results is consistent with increased lipid oxidation caused by rimonabant.

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“…The global shift toward increased obesity has been extensively documented (Haslam and James, 2005;Popkin, 2006). At the same time, undernutrition has persisted in developing countries (Ge and Fu, 2001).…”

Section: Introductionmentioning

confidence: 99%

Under- and overnutrition dynamics in Chinese children and adults (1991–2004)

2007

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Objective: To examine trends in under-and overweight prevalence from 1991 to 2004 among adults and children in China by income and residence differentials. Methods/Subjects: Prevalence, average annual changes and annual relative changes in under-and overweight were determined. In 1991, 2848 children and 6806 adults were surveyed. The 2004 survey included 1566 children and 6172 adults. Results: Higher average annual reductions in underweight prevalence were found among children, particularly rural children, when compared with adults. With respect to income, low-income children and adults experienced the greatest average annual reductions in underweight prevalence. The trend for increased overweight was more pronounced than the trend for decreased underweight. Intensified trends were found among adults (versus children) and males (versus females). Relative to baseline prevalence, overweight increased fastest among adults in low-income and rural populations. Conclusions: Rapid increases in the overweight prevalence, particularly as found among low-income and rural Chinese adults, will likely lead to a shift in the burden of obesity-related chronic diseases toward the poor. Associated economic and health implications will further challenge the country's health care system, restrain economic development and widen existing disparities between the rural and urban as well as between the rich and poor populations of China.

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Obesity

Cited by 4,008 publications

References 84 publications

Impact of obesity on prostate cancer recurrence after radical prostatectomy: Data from CaPSURE

Impact of obesity on prostate cancer recurrence after radical prostatectomy: Data from CaPSURE

Reversal of visceral adiposity in candy-diet fed female Wistar rats by the CB1 receptor antagonist rimonabant

Under- and overnutrition dynamics in Chinese children and adults (1991–2004)

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