Obesity:A Killer Living with Us

Sarumathi, T.; Kumar, B. Saravana; Aakash, S. Sai

doi:10.37506/v10/i12/2019/ijphrd/192257

Indian Journal of Public Health Research &Amp; Development

2019

DOI: 10.37506/v10/i12/2019/ijphrd/192257

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Obesity:A Killer Living with Us

T. Sarumathi

B. Saravana Kumar

S. Sai Aakash³

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2024

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Effects of Hawthorn Flavonoids on Intestinal Microbial Community and Metabolic Phenotype in Obese Rats

Bi,

Lv,

Zhu

et al. 2024

Advanced Biology

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Obesity (OB) is a prevalent metabolic disorder. With the advancement of the economy, the prevention and treatment of obesity is a big problem for the global community. The methods to lose weight include exercise, diet, medicine, and surgery. Compared with other methods, diet regulation is safer and more effective. Hawthorn fruit has the effect of reducing weight, but the mechanism of effectiveness are not clear. In this study, obesity model rats are used to conduct scientific pharmacological research on hawthorn flavonoids. Hawthorn flavonoids can effectively improve the body weight, lipid accumulation, and lipid levels of obese rats. The contents of the colon of rats are analyzed using 16S rDNA sequencing technology. The intestinal microflora in obese rats changed significantly after flavonoids treatment, and they tended to be the control group. Based on liquid chromatography‐mass spectrometry, serum metabolomics showed that the metabolites in the serum changed significantly, after hawthorn flavonoids treatment. Hawthorn flavonoids are especially involved in the biological processes of grade bile acid biosynthesis, histidine metabolism, and lipid metabolism. Pearson correlation analysis showed that the disorder of intestinal microorganisms is connected to changes in serum metabolites. These findings give a new idea about how hawthorn flavonoids help with obesity.

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Effects of Hawthorn Flavonoids on Intestinal Microbial Community and Metabolic Phenotype in Obese Rats

Bi,

Lv,

Zhu

et al. 2024

Advanced Biology

View full text Add to dashboard Cite

show abstract

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Obesity:A Killer Living with Us

Cited by 1 publication

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Effects of Hawthorn Flavonoids on Intestinal Microbial Community and Metabolic Phenotype in Obese Rats

Effects of Hawthorn Flavonoids on Intestinal Microbial Community and Metabolic Phenotype in Obese Rats

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