ABSTRACT
The Siddha system is a traditional holistic medicine. It mainly exists in South India and is regarded as one of India's oldest medical systems. This approach is built on ancient medicinal traditions, spiritual disciplines, alchemy, and mysticism. Medicinal plants have long been used to treat human diseases. Trial medication compositions for the treatment of male infertility were documented in Siddha's ancient literature. The investigation aimed to assess the biochemical analysis of the trial medicine Murungai Nei, which demonstrated the presence of carbonate, sulfates, and phosphate, as well as the augmentation of therapeutic activity in male infertility. As a result, I conclude that the existence of these substances is a treatment for male infertility.