Obesity adversely impacts the number and maturity of oocytes in conventional IVF not in minimal stimulation IVF

Abstract

Female adiposity might impair oocyte number and maturity in conventional IVF but not in mini-IVF. These data suggest that mild ovarian stimulation might yield healthier oocytes in obese women.

Effect of body mass index on the outcomes of controlled ovarian hyperstimulation in Chinese women with polycystic ovary syndrome: a multicenter, prospective, observational study

“…We observed no differences among BMI categories in the number of follicles retrieved, number of embryos, and number of embryos transferred, which are supported by studies in women with PCOS [22] and without PCOS [19,27,28,[31][32][33][34][35][36], but this is controversial [14,21,29,30,37]. Interestingly, we found that women of normal weight had more follicles of 14-18 mm in diameter than BMI body mass index, hCG human chorionic gonadotropin a P = 0.025, intergroup comparisons using one-way analysis of variance b P = 0.132, intergroup comparisons using one-way analysis of variance c P = 0.314, intergroup comparisons using one-way analysis of variance d P = 0.327, intergroup comparisons using one-way analysis of variance e P = 0.033, intergroup comparisons using one-way analysis of variance f P = 0.084, intergroup comparisons using one-way analysis of variance subjects in other BMI categories, which is supported by a previous observation that PCOS and obesity independently influence oocyte size [38], and that obesity may be associated with poorer-quality oocytes [20,28,30,39,40].…”

Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1

“…We have previously shown in humans that obesity has a negative impact on ovarian function, in particular on genes important in follicular development and ovarian reserve [27,[43][44][45][46][47][48]. In the current study, we did not find an association between BMI and kisspeptin expression in human GCs and we did not find that diet-induced obesity affected ovarian kiss1/kiss1r expression in mice.…”

Extremities of body mass index and their association with pregnancy outcomes in women undergoing in vitro fertilization in the United States

“…A s the obesity epidemic continues to plague the United States, numerous reports have been published and recommendations made regarding the negative impact of obesity on fertility (1), assisted reproductive technology (ART) effectiveness (2)(3)(4)(5)(6)(7)(8)(9), and pregnancy and obstetric outcomes (5,10). By contrast, limited and conflicting data exist on the impact of being underweight (body mass index [BMI] <18.5 kg/m 2 ), admittedly a less common problem, on fertility and the effectiveness of ART.…”