Obesity alters retrieved oocyte count and clinical pregnancy rates in high and poor responder women after in vitro fertilization

Kılıç, Sevtap; Yılmaz, Nafiye; Zülfikaroğlu, Ebru; Sarıkaya, Esma; Köse, Kenan; Topcu, Onur; Batıoğlu, Sertaç

doi:10.1007/s00404-010-1359-7

Cited by 14 publications

(11 citation statements)

References 32 publications

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“…Although it was not possible to exclude women who had BMI < 18.5 kg/m 2 from the group of women who were reported as having BMI < 25 kg/m 2 from the data provided in 18 studies (Fedorcsak et al, 2000;Loveland et al, 2001;Ferlitsch et al, 2002;Doody et al, 2003;Ryley et al, 2004;van Swieten et al, 2005;Hammadeh et al, 2005;Munz et al, 2005;Dechaud et al, 2006;Dorkras et al, 2006;Mitwally et al, 2006;Moini et al, 2008;Orvieto et al, 2009a;Farhi et al, 2010;Bellver et al, 2010;Chueca et al, 2010;Vilarino et al, 2010;Sathya et al, 2010), including these women in the current analysis has probably resulted in underestimation of the detrimental effect of raised BMI, as a low BMI (<18.5 kg/m 2 ) is known to be associated with a poorer IVF outcome (Veleva et al, 2008). Furthermore, the subgroup analysis followed the WHO criteria for overweight (BMI 25-29.9 kg/m 2 ) and obese (BMI 30 kg/m 2 ) in order to provide an accurate comparison of normal versus increased BMI (Wang et al, 2000Doody et al, 2003;Ryley et al, 2004;Fedorcsak et al, 2004;Dorkras et al, 2006;Metwally et al, 2007;Sneed et al, 2008;Esinler et al, 2008;Martinuzzi et al, 2008;Bellver et al, 2010;Zhang et al, 2010;Kilic et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis

Rittenberg

Seshadri

Sunkara

et al. 2011

Reproductive BioMedicine Online

364

241

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There is conflicting evidence regarding the effect of raised body mass index (BMI) on the outcome of assisted reproductive technology. In particular, there is insufficient evidence to describe the effect of BMI on live birth rates. We carried out a systematic review and meta-analysis of studies to evaluate the effect of raised BMI on treatment outcome following IVF/ICSI treatment. Subgroup analysis on overweight and obese patients was performed. Literature searches were conducted on MEDLINE, EMBASE and the Web of Science from 1966 to 2010. Thirty-three studies including 47,967 treatment cycles were included. Results indicated that women who were overweight or obese (BMI ≥ 25) had significantly lower clinical pregnancy (RR=0.90, P<0.0001) and live birth rates (RR=0.84, P=0.0002) and significantly higher miscarriage rate (RR=1.31, P < 0.0001) compared to women with a BMI < 25 following treatment. A subgroup analysis of overweight women (BMI ≥ 25-29.9) revealed lower clinical pregnancy (RR=0.91, P=0.0003) and live birth rates (RR=0.91, P=0.01) and higher miscarriage rate (RR=1.24, P < 0.00001) compared to women with normal weight (BMI < 25). In conclusion, raised BMI is associated with adverse pregnancy outcome in women undergoing IVF/ICSI treatment, including lower live birth rates. This effect is present in overweight as well as obese women.

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Section: Discussionmentioning

confidence: 99%

Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis

Rittenberg

Seshadri

Sunkara

et al. 2011

Reproductive BioMedicine Online

364

241

View full text Add to dashboard Cite

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“…And there are many overseas reports that the maternal age is a crucial risk factor when predicting pregnancy outcomes [4-9]. However, Kale (Turkey) reported that there were no negative effects for a 45 year-old woman to deliver a large fetus [10].…”

Section: Introductionmentioning

confidence: 99%

Lifestyle, nutrient intake, iron status, and pregnancy outcome in pregnant women of advanced maternal age

Bae

2011

Nutr Res Pract

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The purpose of this study was to investigate how advanced maternal age influences lifestyle, nutrient intake, iron status, and pregnancy outcomes in pregnant women. The subjects of this study were 112 pregnant women who were receiving prenatal care at gynecologists located in Seoul. The subjects were divided into two groups according to their ages: those over age 35 were the advanced age group of pregnant women (AP) and those under age 35 were the young age group of pregnant women (YP). General factors, nutrient intakes, iron status, and pregnancy outcomes of the two groups were then compared. It was found that 72.5% of the YP group and 51.2% of the AP group had pre-pregnancy alcohol drinking experience; indicating that the YP group had more pre-pregnancy alcohol consumption than the AP group (P < 0.05). The only difference found in nutrient intake between the two groups was their niacin intakes which were 16.83 ± 8.20 mg/day and 13.76 ± 5.28 mg/day, respectively. When gestational age was shorter than 38.7 weeks, the average infant birth weight was 2.95 ± 0.08 kg, and when gestational age was longer than 40 weeks, it averaged at about 3.42 ± 0.08 kg. In other words, as gestational age increased, infant birth weight increased (P < 0.0001), and when maternal weight increased more than 15 kg, the infant birth weight increased significantly (P < 0.05). In conclusion, in order to secure healthy human resources, with respect to advanced aged women, it is necessary to intervene by promoting daily habits that consist of strategic increases in folate and calcium intake along with appropriate amounts of exercise.

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“…This study analyzed the number of 45,000 embryo transfers and concluded that higher obesity levels (BMI values) resulted in a significant increase in the ability to achieve clinical pregnancy via the use of autologous oocytes but resulted in no differences in the use of donor oocytes. Besides, it reported that the adverse effects of ob- [45]. The fertilization and pregnancy rate were not affected once oocytes retrieved [46] [47] [48].…”

Section: Discussionmentioning

confidence: 99%

Obesity in Relation to Ovarian Response in IVF Treatment

Hashim¹,

Gehad²,

Khalid³

et al. 2018

ARSci

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Introduction: The effect of Body Mass Index (BMI), which reflects the woman's obesity, in IVF treatment cycle, remains unclear. In 1997, the World Health Organization (WHO) provided authoritative refinements to the overweight terminology and BMI cutoffs [1]. Objective: To verify the relationship between BMI and ovarian response in IVF treatment cycle. Design: Retrospective study. Materials & Methods: The study includes 2625 IVF treatment cycles performed in our IVF center in the period of 4 years. Patients were divided into five groups using the WHO criteria according to their BMI [2]. Cancellation rate, mean last E2 before hCG administration, mean endometrial thickness, mean duration of stimulation, number of eggs retrieved, fertilization rate, pregnancy and abortion rates were analyzed. The unpaired t-test was used in statistical analysis. Results: There was statistically significant less mean oestradiol level prior to hCG, less endometrial thickness and less number of simulation days as BMI gets higher. In contrast, there was a positive relationship between cancellation rate and higher BMI except with BMI >39 which was not, possibly due to lower number of patients available. But if we look at the cause of cancellation, it was 100% due to insufficient number of follicles obtained for this group (BMI >39). Also, days of stimulation are significantly lower for the same group of patients in comparison with the other groups. Retrieval, fertilization and pregnancy rates were not significant between all groups. Abortion rate gets significantly higher as BMI increased. Conclusion: Overweight affects ovulation, if we consider the cause of cancellation being insufficient number of follicles reflects the poor response. The fertilization and pregnancy rate were not affected once oocytes retrieved. The reduction of weight is an important How to cite this paper: Hashim, H., Gehad, M51Advances in Reproductive Sciences part of infertility treatment in obese women with regards to the ovarian response and abortion rate in IVF cycle.

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Obesity alters retrieved oocyte count and clinical pregnancy rates in high and poor responder women after in vitro fertilization

Cited by 14 publications

References 32 publications

Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis

Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis

Lifestyle, nutrient intake, iron status, and pregnancy outcome in pregnant women of advanced maternal age

Obesity in Relation to Ovarian Response in IVF Treatment

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