Obesity and anovulatory infertility: A review

Giviziez, Christiane Ricaldoni; Sanchez, Eliane G M; Approbato, Mário Silva; Maia, Mariana; Fleury, Eliamar A. B.; Sasaki, Reinaldo Satoru Azevedo

doi:10.5935/1518-0557.20160046

Cited by 39 publications

(30 citation statements)

References 50 publications

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“…However most of the published literature shows that obesity decreases the fertility outcomes in infertile women however no one have mentioned the Cutoff for BMI to observed the decreased fertility. 16,17 In present study average BMI for combined, primary and secondary infertile patients was 21.80Kg/m 2 , 21.84Kg/m 2 and 21.7Kg/m 2 respectively. So most of the included patients are within the normal range of BMI and this reason might be responsible for we did not observe the effect of the BMI on fertility outcome.…”

Section: Patient's Demographics and Clinical Parameterssupporting

confidence: 45%

Do accessory parameters affect the outcome of the endoscopic procedures in female infertile patients?: an experience at a single tertiary care center

Agrawal

Yadav

Fayyaz

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: In modern era, endoscopic methods are commonly used in evaluation of female infertility. Hysterolaparoscopy is such a real time theranostic modality for anatomical causes of the infertility. The objective of this study was to evaluate the effect of accessory parameters (Age, Body mass index, duration of infertility, Rhesus factor, menstruation history and hemoglobin) on success rate of endoscopic procedures in terms of achieving pregnancy.Methods: A total 157 female infertile patients (Mean± standard deviation 27.72±3.82 years) were recruited in present study. During initial assessment detailed history was taken and hysterolaparoscopy was performed. The observed structural abnormalities on hysterolaparoscopy during diagnostic work up were tackled at same time if possible. After procedure, patients were counselled for regular sexual activity. The follow-up of all patients was done for 12 months.Results: A total 157 female infertile patients were recruited and divided into primary 93 (59.2%) and secondary infertile 64 (41.74%) patients on basis of obstetric history. The average age, BMI, hemoglobin and duration of infertility were 27.7years, 21.8 kg/m2, 12.3 gm and 3.9 years respectively. Out of 157 patients, anatomical abnormalities were detected in 125 patients during Hysterolaparoscopy and distributed in 77/93 (82.8%) primary and 48/64 (75%) secondary infertile patients. Of 125 patients with abnormal hysterolaparoscopic findings, 121 underwent active intervention and on follow up, 43 patients were conceived. We found that age; BMI, Rhesus factor, menstruation history and duration of the infertility were not correlated with fertility outcome while hemoglobin level was significantly correlated with conception rate.Conclusions: Authors concluded that outcome of the hysterolaparoscopy in female infertile patients is significantly depends upon hemoglobin levels, however outcome is irrelevant to age, duration of infertility, Rhesus factor and body mass index.

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Section: Patient's Demographics and Clinical Parameterssupporting

confidence: 45%

Do accessory parameters affect the outcome of the endoscopic procedures in female infertile patients?: an experience at a single tertiary care center

Agrawal

Yadav

Fayyaz

et al. 2019

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…The excess estrogens produced by the adipose tissue provides a growth signal for the endometrium that is unopposed by progesterone. Obesity also leads to higher rates of anovulation [ 21 ] with a relative risk above 2 for body mass index greater than 29 [ 22 ]; however, most obese women have normal ovulatory menstrual cycles [ 23 ]. In anovulatory women, the lack of ovulation and corpus luteum production keeps progesterone levels low.…”

Section: Estrogen-associated Risk Factors For Endometrial Cancermentioning

confidence: 99%

Estrogen Signaling in Endometrial Cancer: a Key Oncogenic Pathway with Several Open Questions

et al. 2019

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Endometrial cancer is the most common gynecological cancer in the developed world, and it is one of the few cancer types that is becoming more prevalent and leading to more deaths in the USA each year. The majority of endometrial tumors are considered to be hormonally driven, where estrogen signaling through estrogen receptor α (ER) acts as an oncogenic signal. The major risk factors and some treatment options for endometrial cancer patients emphasize a key role for estrogen signaling in the disease. Despite the strong connections between estrogen signaling and endometrial cancer, important molecular aspects of ER function remain poorly understood; however, progress is being made in our understanding of estrogen signaling in endometrial cancer. Here, we discuss the evidence for the importance of estrogen signaling in endometrial cancer, details of the endometrial cancer-specific actions of ER, and open questions surrounding estrogen signaling in endometrial cancer.

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“…Extreme body weights affect reproductive function through changes in the hypothalamic-pituitary-gonadal axis, causing periods of oligo-anovulation, as well as menstrual disorders ( Brewer & Balen, 2010 ; Giviziez et al , 2016 ; Grodstein et al , 1994 ; Sathya et al , 2010 ). When the fat mass is too low, the secretion of gonadotropins and, consequently, the reproductive capacity is reduced.…”

Section: Introductionmentioning

confidence: 99%

The adverse effect of overweight in assisted reproduction treatment outcomes

Sampo¹,

Palena²,

Ganzer³

et al. 2017

JBRA Assisted Reproduction

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ObjectiveTo assess Body Mass Index (BMI) effects on the results obtained from ICSI cycles.MethodsWe studied 266 ICSI cycles performed between January 2014 and December 2016. The patients were grouped according to their BMI in: Normal (18.5-24.9), Overweight (25.0-29.9) and Obese (>30). We compared the following variables between the groups: number of antral follicles, ovarian stimulation length, gonadotropin dose used, maximum estradiol level, follicles developed/antral follicles, retrieved oocytes/developed follicles and mature/retrieved oocytes, normal fertilization rate, embryo achieved/normal fertilized oocytes, clinical pregnancy and implantation rates. We used the Kruskal-Wallis and the Chi square tests. p<0.05 was considered significant.ResultsNormal, Overweight and Obese patients presented comparable values for number of antral follicles (11.6±5.4, 12.5±5.5, 12.2±5.7), ovarian stimulation length (7.5±1.4, 7.6±1.1, 7.8±1.3) and gonadotropin dose used (2043±489, 1940±536, 2109±605). Obese patients had lower values of estradiol (1560±610, 1511±635, 1190±466; p=0.018), developed follicles (81%, 76%, 70%; p<0.0001), and retrieved oocytes (91%, 90%, 84%; p=0.0017); and not significantly lower values of mature oocytes (82%, 82%, 77%; p=0.26). The groups had comparable fertilization rates (72%, 73%, 69%) and embryo achieved rates (67%, 63%, 72%). The normal group had higher, but not significantly higher pregnancy and implantation rates (43%, 40%, 38%, p=0.53; and 33%, 26%, 23%; p=0.11), and significantly higher ongoing pregnancy rates (37%, 33%, 33%, p=0.042).ConclusionIncreased BMI patients had impaired ovarian response and lower pregnancy rates in ICSI cycles.

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Obesity and anovulatory infertility: A review

Cited by 39 publications

References 50 publications

Do accessory parameters affect the outcome of the endoscopic procedures in female infertile patients?: an experience at a single tertiary care center

Do accessory parameters affect the outcome of the endoscopic procedures in female infertile patients?: an experience at a single tertiary care center

Estrogen Signaling in Endometrial Cancer: a Key Oncogenic Pathway with Several Open Questions

The adverse effect of overweight in assisted reproduction treatment outcomes

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