Obesity and Asthma

Limaye, Sneha; Salvi, Sundeep

doi:10.1016/j.iac.2014.07.005

Cited by 15 publications

(7 citation statements)

References 79 publications

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“…These patients with diabetes are more prone to the detrimental effects of PM 2.5 and lower-sized particulate matter, leading to increased serum levels of inflammatory biomarkers, coagulation factors, and vasoconstrictor mediators, predisposing them to increased cardiovascular morbidity and subsequently amplified mortality. Obesogens, as discussed previously, affect the endocrine system, increasing the risk of metabolic syndrome and diabetes as well as cardiovascular risks 29 .…”

Section: Effects Of Household Air Pollutionmentioning

confidence: 86%

Household air pollution and its effects on health

Apte¹,

Salvi²

2016

F1000Res

Self Cite

138

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Household air pollution is a leading cause of disability-adjusted life years in Southeast Asia and the third leading cause of disability-adjusted life years globally. There are at least sixty sources of household air pollution, and these vary from country to country. Indoor tobacco smoking, construction material used in building houses, fuel used for cooking, heating and lighting, use of incense and various forms of mosquito repellents, use of pesticides and chemicals used for cleaning at home, and use of artificial fragrances are some of the various sources that contribute to household air pollution. Household air pollution affects all stages of life with multi-systemic health effects, and its effects are evident right from pre-conception to old age. In utero exposure to household air pollutants has been shown to have health effects which resonate over the entire lifetime. Exposures to indoor air pollutants in early childhood also tend to have repercussions throughout life. The respiratory system bears the maximum brunt, but effects on the cardiovascular system, endocrine system, and nervous system are largely underplayed. Household air pollutants have also been implicated in the development of various types of cancers. Identifying household air pollutants and their health implications helps us prepare for various health-related issues. However, the real challenge is adopting changes to reduce the health effects of household air pollution and designing innovative interventions to minimize the risk of further exposure. This review is an attempt to understand the various sources of household air pollution, the effects on health, and strategies to deal with this emergent risk factor of global mortality and morbidity.

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Section: Effects Of Household Air Pollutionmentioning

confidence: 86%

Household air pollution and its effects on health

Apte¹,

Salvi²

2016

F1000Res

Self Cite

138

View full text Add to dashboard Cite

show abstract

“…A few studies have investigated possible interactions between common antioxidant gene polymorphisms and antioxidant intake or physical activity affecting atopic and respiratory outcomes [144][145][146]. As obesity is now a well-known risk factor for asthma, trying to understand better how obesity might modify associations between oxidant exposures, such as air pollution, and asthma is particularly relevant [147]. Some studies have suggested that diet may act as an effect modifier and modulate the adverse effect of air pollution on asthma outcomes [148][149][150].…”

Section: The Association Between Nutritional Factors and Asthma: An Ementioning

confidence: 99%

The Role of Nutritional Factors in Asthma: Challenges and Opportunities for Epidemiological Research

Bédard

Ait‐hadad

et al. 2021

IJERPH

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The prevalence of asthma has nearly doubled over the last decades. Twentieth century changes in environmental and lifestyle factors, including changes in dietary habits, physical activity and the obesity epidemic, have been suggested to play a role in the increase of asthma prevalence and uncontrolled asthma worldwide. A large body of evidence has suggested that obesity is a likely risk factor for asthma, but mechanisms are still unclear. Regarding diet and physical activity, the literature remains inconclusive. Although the investigation of nutritional factors as a whole (i.e., the “diet, physical activity and body composition” triad) is highly relevant in terms of understanding underlying mechanisms, as well as designing effective public health interventions, their combined effects across the life course has not received a lot of attention. In this review, we discuss the state of the art regarding the role of nutritional factors in asthma, for each window of exposure. We focus on the methodological and conceptual challenges encountered in the investigation of the complex time-dependent interrelations between nutritional factors and asthma and its control, and their interaction with other determinants of asthma. Lastly, we provide guidance on how to address these challenges, as well as suggestions for future research.

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“…Recent studies suggest that the interaction between obesity and asthma is more complex than has been reported so far and goes beyond a simple association between excess weight and asthma. In this line, there are studies that show that the characteristics of the diet, such as the acid load of the diet [5] or the exposure to some chemical compounds and indoor and outdoor pollutants can also contribute to the association of obesity and asthma [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Asthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation

Bantulà

Roca‐Ferrer

Arismendi

et al. 2021

JCM

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Asthma and obesity are two epidemics affecting the developed world. The relationship between obesity and both asthma and severe asthma appears to be weight-dependent, causal, partly genetic, and probably bidirectional. There are two distinct phenotypes: 1. Allergic asthma in children with obesity, which worsens a pre-existing asthma, and 2. An often non allergic, late-onset asthma developing as a consequence of obesity. In obesity, infiltration of adipose tissue by macrophages M1, together with an increased expression of multiple mediators that amplify and propagate inflammation, is considered as the culprit of obesity-related inflammation. Adipose tissue is an important source of adipokines, such as pro-inflammatory leptin, produced in excess in obesity, and adiponectin with anti-inflammatory effects with reduced synthesis. The inflammatory process also involves the synthesis of pro-inflammatory cytokines such as IL-1β, IL-6, TNFα, and TGFβ, which also contribute to asthma pathogenesis. In contrast, asthma pro-inflammatory cytokines such as IL-4, IL-5, IL-13, and IL-33 contribute to maintain the lean state. The resulting regulatory effects of the immunomodulatory pathways underlying both diseases have been hypothesized to be one of the mechanisms by which obesity increases asthma risk and severity. Reduction of weight by diet, exercise, or bariatric surgery reduces inflammatory activity and improves asthma and lung function.

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Obesity and Asthma

Cited by 15 publications

References 79 publications

Household air pollution and its effects on health

Household air pollution and its effects on health

The Role of Nutritional Factors in Asthma: Challenges and Opportunities for Epidemiological Research

Asthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation

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