Obesity and asthma: clinical and laboratory characterization of a common combination

Jesus, Juliana Pires Viana de; Lima-Matos, Aline; Almeida, Paula; Lima, Valmar Bião; Mello, Luane Marques de; Souza‐Machado, Adelmir; Ponte, Eduardo Vieira; Cruz, Álvaro Augusto

doi:10.1590/s1806-37562017000000034

Cited by 28 publications

(22 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An association between obesity and asthma, especially, in females may exist. Though, the causality between obesity and asthma is still uncertain; a suggested explanation is due to changes in systemic metabolism 15,44,45 …”

Section: Discussionmentioning

confidence: 99%

Combinations of self‐reported rhinitis, conjunctivitis, and asthma predicts IgE sensitization in more than 25,000 Danes

Mikkelsen

Dinh

Boldsen

et al. 2021

Clinical & Translational All

View full text Add to dashboard Cite

Background Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma composing multiple phenotypes and improved understanding of these phenotypes and their respective risk factors are needed. Objectives The objective of this study was to define the prevalence of AR, AC, and asthma and their association with allergen‐specific immunoglobulin E (sIgE) sensitization in a large cohort of blood donors and identify risk factors. Methods From the nationwide population‐based Danish Blood Donor Study, 52,976 participants completed an electronic questionnaire including AR, AC, asthma, allergic predisposition, and childhood residence. Of these, 25,257 were additionally tested for sIgE to inhalation allergens (Phadiatop). Results The prevalence of sIgE sensitization, AR, AC, and asthma was 30%, 19%, 15%, and 9%, respectively. The youngest birth cohorts had the highest prevalence of sIgE sensitization and symptoms of asthma, AR, and AC, and for asthma, they apparently experienced symptoms at an earlier age. The sIgE sensitization was positively associated with male sex. The sIgE seroprevalence was higher in participants with both AR and AC (ARC) than in participants with either AR or AC. Allergic predisposition and sIgE sensitization increased the risk of the diseases, while farm upbringing was associated with reduced prevalence of ARC, however, only in sIgE sensitized participants. Conclusion Birth year, childhood residence, sIgE sensitization, and allergic predisposition were associated with asthma, AR, and AC prevalence. Individuals with self‐reported ARC represent a primarily sIgE‐positive phenotype, while those with either AR or AC represent more diverse phenotypes.

show abstract

Section: Discussionmentioning

confidence: 99%

Combinations of self‐reported rhinitis, conjunctivitis, and asthma predicts IgE sensitization in more than 25,000 Danes

Mikkelsen

Dinh

Boldsen

et al. 2021

Clinical & Translational All

View full text Add to dashboard Cite

show abstract

“…Nevertheless, eosinophilic asthma can be found in obese people, since obesity can also be a cofactor in other asthma phenotypes. 75 A recent study by Jesus et al 76 showed that obese asthmatics tend to have worse asthma control than non-obese patients. Moreover, decreased prevalence of atopy and higher basophil counts were observed among these obese asthma patients.…”

Section: Causative Agents and Risk Factorsmentioning

confidence: 99%

“…Moreover, decreased prevalence of atopy and higher basophil counts were observed among these obese asthma patients. 76 …”

Section: Causative Agents and Risk Factorsmentioning

confidence: 99%

Non-eosinophilic asthma: current perspectives

Esteban-Gorgojo¹,

Antolín‐Amérigo

Domínguez‐Ortega

et al. 2018

JAA

View full text Add to dashboard Cite

Although non-eosinophilic asthma (NEA) is not the best known and most prevalent asthma phenotype, its importance cannot be underestimated. NEA is characterized by airway inflammation with the absence of eosinophils, subsequent to activation of non-predominant type 2 immunologic pathways. This phenotype, which possibly includes several not well-defined subphenotypes, is defined by an eosinophil count <2% in sputum. NEA has been associated with environmental and/or host factors, such as smoking cigarettes, pollution, work-related agents, infections, and obesity. These risk factors, alone or in conjunction, can activate specific cellular and molecular pathways leading to non-type 2 inflammation. The most relevant clinical trait of NEA is its poor response to standard asthma treatments, especially to inhaled corticosteroids, leading to a higher severity of disease and to difficult-to-control asthma. Indeed, NEA constitutes about 50% of severe asthma cases. Since most current and forthcoming biologic therapies specifically target type 2 asthma phenotypes, such as uncontrolled severe eosinophilic or allergic asthma, there is a dramatic lack of effective treatments for uncontrolled non-type 2 asthma. Research efforts are now focusing on elucidating the phenotypes underlying the non-type 2 asthma, and several studies are being conducted with new drugs and biologics aiming to develop effective strategies for this type of asthma, and various immunologic pathways are being scrutinized to optimize efficacy and to abolish possible adverse effects.

show abstract

“…Numerous studies are showing that obesity increases the risk of bronchial [27][28][29]. There is also a study that the relationship and the effect between the two diseases are bilateral [30].…”

Section: Discussionmentioning

confidence: 99%

Chronic diseases and obesity risk: Analysis of Turkish data

Ikizek¹

2021

J CLIN MED KAZ

View full text Add to dashboard Cite

Objective: Obesity is a disease with multifactorial and complex etiology. While some chronic diseases are a risk factor for the development of obesity, obesity is associated with the incidence of many chronic diseases. This study aims to determine how much chronic diseases and various socio-demographic variables increase the risk of obesity [body mass index (BMI)].Material and methods: In the study, the group of adults aged 18 and older was analyzed using a data set representing Turkey. The variables used in the analysis were obtained from the "TurkStat Health Survey" micro data set for 2016. In total, fifteen chronic disease types were analyzed using three models, seven binary regression analysis. The analyzes were carried out with 11,374 people.Results: According to the results obtained in the basic model, bronchial asthma increases the risk of obesity by 1,22 times (p<0,01), chronic bronchitis 1,31 times (p<0,001), essential hypertension 1,55 times (p<0,001), lumbar disc herniation 1,15 times (p<0,001), diabetes mellitus 1,614 times (p<0,001), and urinary incontinence 1,29 times (p<0,001), compared to people without disease (p<0,05). According to the results obtained in the disease model, bronchial asthma increases the risk of obesity by 1,29 times (p<0,001), chronic bronchitis 1,29 times (p<0,001), essential hypertension 1,661 times (p<0,001), lumbar disc herniation 1,219 times (p<0,001), diabetes mellitus 1,625 times (p<0,001), and urinary incontinence 1,334 times (p<0,001) compared to people without disease, stroke (0,234 times), cervical disc herniation (0,671 times) and liver failure (0,502 times) reduce the risk of obesity compared to people without disease (p <0,05). In regression models based on both disease and health models, more chronic diseases increase the risk of obesity in women compared to men.Conclusion: Diseases such as asthma, chronic bronchitis, diabetes, urinary incontinence, hypertension, and lumbar disc herniation were found to increase the risk of obesity. Diseases that increase the risk of obesity should be fought at the source.

show abstract

Obesity and asthma: clinical and laboratory characterization of a common combination

Cited by 28 publications

References 33 publications

Combinations of self‐reported rhinitis, conjunctivitis, and asthma predicts IgE sensitization in more than 25,000 Danes

Combinations of self‐reported rhinitis, conjunctivitis, and asthma predicts IgE sensitization in more than 25,000 Danes

Non-eosinophilic asthma: current perspectives

Chronic diseases and obesity risk: Analysis of Turkish data

Contact Info

Product

Resources

About