Obesity and atrial fibrillation

Ergün, Gökhan; Başaran, Özcan; Doğan, Volkan; Doğan, Marwa Mouline; Biteker, Murat

doi:10.1016/j.ijcard.2016.08.064

Cited by 5 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epidemiologic studies and clinical data both indicate that obesity is commonly associated with AF, and stable weight loss decreases AF burden and AF recurrence following treatment [ 21 ]. Mild inflammation, insulin resistance, and structural remodeling in obese patients are believed to be the major reasons for the development of AF [ 22 ]. Another study found that serum YKL-40 is elevated in morbidly obese patients and declines after weight loss [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

YKL-40 is highly expressed in the epicardial adipose tissue of patients with atrial fibrillation and associated with atrial fibrosis

et al. 2018

View full text Add to dashboard Cite

BackgroundYKL-40 (CHI3L1) is a novel biomarker for inflammation, tissue remodeling, and fibrosis, as well as cardiovascular diseases. We investigated the association between YKL-40 expression in epicardial adipose tissue (EAT) and atrial fibrosis in patients with atrial fibrillation (AF).MethodsBlood samples, subcutaneous adipose tissue (SAT), paracardial adipose tissue (PAT), EAT, and adjacent atrial myocardium were acquired from patients receiving coronary artery bypass grafts. The patients were divided into the AF group (n = 28) and the sinus rhythm (SR) group (n = 36).ResultsWe did not detect a significant difference in the serum YKL-40 levels in the SR and AF groups (P = 0.145). Quantitative real-time PCR showed that YKL-40 (CHI3L1) mRNA levels in the EAT were significantly higher than in the SAT or PAT of AF patients, or the EAT of SR patients (All P < 0.001). We found similar results for YKL-40 protein levels by immunohistochemistry. Masson staining showed significantly more fibrosis in AF patients than in SR patients (P < 0.001). Western blotting indicated that AF patients had significantly higher expression of collagen I (P = 0.039). We found a linear relationship between YKL-40 mRNA expression and the collagen volume fraction of the atrial myocardium (y = 3.576x + 26.205, P < 0.001). Multivariate linear regression analysis revealed that body mass index is an independent risk factor for YKL-40 expression in EAT (β = 0.328, P = 0.011).ConclusionsYKL-40, which is highly expressed in the EAT of patients with AF, is affected by body mass index and associated with atrial fibrosis, which may contribute to the development of AF.

show abstract

Section: Discussionmentioning

confidence: 99%

YKL-40 is highly expressed in the epicardial adipose tissue of patients with atrial fibrillation and associated with atrial fibrosis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Despite the exponential growth of knowledge in the clinical treatment of atrial fibrillation (AF), the underlying mechanism remains not entirely elucidated, which Limits the clinical efficacy 1 . Obesity, as a worldwide health problem with epidemic proportions, has been demonstrated to be an essential risk factor for AF 2 . It is reported that the overweight population suffers higher incidence, prevalence, severity and progression of AF compared with their normal‐weight counterparts, while weight loss could significantly reverse atrial remodelling and decreases AF burden and AF recurrence following treatment 3 .…”

Section: Introductionmentioning

confidence: 99%

Inhibition of endoplasmic reticulum stress prevents high‐fat diet mediated atrial fibrosis and fibrillation

Zhang

Yang

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

Despite the exponential growth of knowledge in the clinical treatment of atrial fibrillation (AF), the underlying mechanism remains not entirely elucidated, which Limits the clinical efficacy. 1 Obesity, as a worldwide health problem with epidemic proportions, has been demonstrated to be an essential risk factor for AF. 2 It is reported that the overweight population suffers higher incidence, prevalence, severity and progression of AF compared with their normal-weight counterparts, while weight loss could significantly

show abstract

“…Obesity is considered to be a risk factor for developing thrombosis, especially deep vein thrombosis (DVT) and pulmonary embolism (PE). It also increases the risk of atrial fibrillation [3,[8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Warfarin Dosing Requirement According to Body Mass Index

Alshammari

Altuwayjiri

Alshaharani

et al. 2020

Cureus

View full text Add to dashboard Cite

Introduction Many factors affect the required dose of warfarin, including body weight, which is mentioned only in a few studies. Our study was conducted using body mass index (BMI) to assess the requirements for warfarin dosing. Methods A retrospective study was conducted that included adults who used warfarin for more than three months, with at least two consecutive international ratio (INR) readings within the therapeutic range. Results Over 301 patients were included; the 20% higher dose of warfarin was required in obese patients than normal BMI and overweight patients (32.2 ± 15.2 vs. 27.4 ±17.3 and 26.8 ± 12.7; p=0.013, respectively). Conclusion Obese patients required a higher dose than other patients, which should be considered when initiating or adjusting the warfarin dose.

show abstract

Obesity and atrial fibrillation

Cited by 5 publications

References 5 publications

YKL-40 is highly expressed in the epicardial adipose tissue of patients with atrial fibrillation and associated with atrial fibrosis

YKL-40 is highly expressed in the epicardial adipose tissue of patients with atrial fibrillation and associated with atrial fibrosis

Inhibition of endoplasmic reticulum stress prevents high‐fat diet mediated atrial fibrosis and fibrillation

Warfarin Dosing Requirement According to Body Mass Index

Contact Info

Product

Resources

About