Obesity and bariatric intervention in patients with chronic renal disease

Bellini, Maria Irene; Paoletti, Filippo; Herbert, Paul

doi:10.1177/0300060519843755

Cited by 28 publications

(23 citation statements)

References 85 publications

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“…Several studies showed that; the FDRs of ESRD patients with a family history are at risk to develop CKD (14,15). Furthermore, increased stocktickerBMI and obesity were found to be having direct impact on the development of CKD and ESRD (12), through a compensatory mechanism of hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight and the increase in intraglomerular pressure which can damage the kidney structure and raise the risk of developing CKD in long term (12,16). Recently, screening and early detection of CKDs researches have performed to decrease the prevalence of CKD, minimize the incidence of ESRD and to reduce their different health, social and economic effect (17,18).…”

Section: Introductionmentioning

confidence: 99%

Obese First degree relatives of hemodialysis patients are at Higher Risk for Developing Kidney Diseases: In a Cross-sectional Study

Elemam

2019

SJMS

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Background: Previously, it has been demonstrated that obesity is one of the strongest risk factors for incident chronic kidney diseases (CKDs). Currently, we examine the association between Body mass index (BMI) and CKD in first degree relatives (FDRs) of renal failure patients on hemodialysis. Materials and methods: In a cross-sectional study, 135 FDRs of end-stage renal disease (ESRD) patients on hemodialysis were included. Serum creatinine, uric acid, calcium, phosphate, and alkaline phosphatase were measured. Glomerular filtration rate (e-GFR) and albumin to creatinine ratio (ACR) were estimated. The height in Cm, weight in Kg was measured, and the BMI was calculated. Results: Females 64% were found to have a higher frequency than males 36%. The frequency of BMI categories was found to be 26.7% obese, 26.7% overweight, and 46.6. % normal weight. The mean BMI was (26.0 ± 6.62). The prevalence of CKDs is 19.3% among relatives. CKDs were more frequent 42.3 % in obese, followed by 30.8 % in overweight and 26.9% in normal-weight relatives. Obese and overweight relatives have significantly higher ACR than normal weight (P= 0.012). GFR found to be significantly higher in obese and overweight relatives than normal weight (P = 0.000). GFR was negatively correlated with BMI (R = - 0.430, P = 0.000). Conclusion: Obese and overweight RF relatives had higher ACR and lower eGFR. Therefore, obese and overweight members are at higher risk of developing CKD. Keywords: CKDs, Family members, BMI, Obesity, ACR, eGFR. Corresponding author: Abozaid Mohammed Hamid, email: elemam69@hotmail.com

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Section: Introductionmentioning

confidence: 99%

Obese First degree relatives of hemodialysis patients are at Higher Risk for Developing Kidney Diseases: In a Cross-sectional Study

Elemam

2019

SJMS

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“…Additional study would enrich the data regarding VAI as a predictor of CKD in the Asian population, and may provide guidance for prevention and treatment of chronic diseases and government decision-making. Patients should receive lifestyle education, including meal plans, exercise plans, and other methods 34,35 weight loss, to intervene kidney disease. This study suffered from several limitations.…”

Section: Discussionmentioning

confidence: 99%

<p>Visceral Adiposity Index and Chronic Kidney Disease in a Non-Diabetic Population: A Cross-Sectional Study</p>

Xiong¹,

Shao²,

Gao³

et al. 2020

DMSO

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To investigate the correlation between visceral obesity and pathogenesis of chronic kidney disease (CKD) among non-diabetic individuals, and to evaluate the potential of visceral adiposity index (VAI) as a predictor of CKD. Patients and Methods: From December 2017 to March 2018, 1877 non-diabetic participants (male n=699, female n=1208) in southern China were recruited for a cross-sectional survey. Males and females were divided into four groups according to gender-specific quartiles of VAI scores. A logistic regression model was established to analyze the correlation between visceral adiposity index and CKD. Results: Visceral adiposity index was positively correlated with CKD and was negatively associated with estimated glomerular filtration rate (eGFR). Using group one as the control, odds ratios (ORs) were calculated to determine the risk of developing CKD as VAI increased (male: group four 2.73 [P<0.005]; female: Group three 1.76 [P<0.05], Group four 2.88 [P<0.005]). When related factors such as history of hypertension, smoking, alcohol use, and physical inactivity were normalized in the logistic model before calculation, ORs became 2.73 (male: P<0.05), and 2.18 (female: P<0.05), respectively. The results differed after normalizing further for systolic blood pressure (SBP), diastolic blood pressure (DBP), hypersensitive c-reactive protein (hsCRP), interleukin-6 (IL-6), homocysteine (Hcy), superoxide dismutase (SOD), and retinol-binding protein (RBP). There were no significant differences in ORs among the female groups. Conclusion: Visceral adiposity index was significantly associated with CKD in non-diabetic individuals. It may be a good predictor of the pathogenesis of CKD and was dependent on hsCRP, IL-6, Hcy, SOD, RBP, and blood pressure levels in females and males with VAI scores of 1.41 and higher. Visceral adiposity index may be used to predict CKD in males with VAI less than 0.983.

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“…The 26% of living donors in our cohort had a BMI > 30, but there was no increased risk in terms of mean eGFRs and Δ eGFR or recovery in kidney function during the 60 months follow up (Figure 4A,B). As it is the case with age, our centre policy does not rely for LD risk on the basis of BMI only: Potential candidates are screened on the basis of a multi-disciplinary input and discussion with a multifactorial analysis, tailored on a case-by-case basis to consider the overall medical condition, rather than a single factor [25]. In our centre, we screen potential donors on the basis of a multi-disciplinary input and discussion.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Donors’ Demographic Characteristics in Renal Function Post-Living Kidney Donation. Analysis of a UK Single Centre Cohort

Bellini

Charalampidis

Stratigos

et al. 2019

JCM

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Introduction: There is a great need to increase the organ donor pool, particularly for living donors. This study analyses the difference in post-living donation kidney function according to pre-donation characteristics of age, genetic relationship with the recipient, sex, ethnicity, and Body Mass Index (BMI). Methods: Retrospective single centre analysis of the trajectory of estimated Glomerular Filtration Rate (eGFR) post-living kidney donation, as a measure of kidney function. Mean eGFR of the different groups was compared at 6 months and during the 60 months follow up. Results: Mean age was 46 ± 13 years, 57% were female, and 60% Caucasian. Mean BMI was 27 ± 5 kg/m2, with more than a quarter of the cohort having a BMI > 30 (26%), and the majority of the donors genetically related to their recipients (56%). The higher decline rate in eGFR was at 6 months after donation, with female sex, non-Caucasian ethnicity, and age lower than 60 years being independently associated with higher recovery in kidney function (p < 0.05). In the 60 months follow up, older age, genetic relationship with the recipient, and male sex led to higher percentual difference in eGFR post-donation. Conclusion: In this study, with a high proportion of high BMI living kidney donors, female sex, age lower than 60 years, and non-genetic relationship with recipient were persistently associated with higher increase in post-donation kidney function. Ethnicity and BMI, per se, should not be a barrier to increasing the living donor kidney pool.

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Obesity and bariatric intervention in patients with chronic renal disease

Cited by 28 publications

References 85 publications

Obese First degree relatives of hemodialysis patients are at Higher Risk for Developing Kidney Diseases: In a Cross-sectional Study

Obese First degree relatives of hemodialysis patients are at Higher Risk for Developing Kidney Diseases: In a Cross-sectional Study

<p>Visceral Adiposity Index and Chronic Kidney Disease in a Non-Diabetic Population: A Cross-Sectional Study</p>

The Effect of Donors’ Demographic Characteristics in Renal Function Post-Living Kidney Donation. Analysis of a UK Single Centre Cohort

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