Obesity and brain illness: from cognitive and psychological evidences to obesity paradox

Monda, Vincenzo; Marra, Marco La; Perrella, Raffaella; Caviglia, Giorgio; Iavarone, Alessandro; Chieffi, Sergio; Messina, Giovanni; Carotenuto, Marco; Monda, Marcellino; Messina, Antonietta

doi:10.2147/dmso.s148392

Cited by 52 publications

(44 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For instance, a recent analysis of the Whitehall II study of > 10,000 individuals in the UK found obesity at age 50 but not at age 60 or 70 predicted dementia risk [56]. Some studies even corroborate an “obesity paradox” with beneficial effects of obesity on cognitive function in later life [57] which may reflect effects of prodromal stages of dementia on body weight [56, 58]. We have no information on body weight status at midlife or weight trajectories of participants but suspect that similar processes may underlie the lack of an association of obesity and POCD risk in the present analysis.…”

Section: Discussionmentioning

confidence: 99%

Diabetes, but Not Hypertension and Obesity, Is Associated with Postoperative Cognitive Dysfunction

Lachmann

Feinkohl

Borchers

et al. 2018

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background/Aims: Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity. Methods: Original data from 3 randomised controlled trials (OCTOPUS, DECS, SuDoCo) were obtained for secondary analysis on diabetes, hypertension, baseline blood pressure, obesity (BMI ≥30 kg/m²), and BMI as risk factors for POCD in multiple logistic regression models. Risk estimates were pooled across the 3 studies. Results: Analyses totalled 1,034 patients. POCD occurred in 5.2% of patients in DECS, in 9.4% in SuDoCo, and in 32.1% of patients in OCTOPUS. After adjustment for age, sex, surgery type, randomisation, obesity, and hypertension, diabetes was associated with a 1.84-fold increased risk of POCD (OR 1.84; 95% CI 1.14, 2.97; p = 0.01). Obesity, BMI, hypertension, and baseline blood pressure were each not associated with POCD in fully adjusted models (all p > 0.05). Conclusion: Diabetes, but not obesity or hypertension, is associated with increased POCD risk. Consideration of diabetes status may be helpful for risk assessment of surgical patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Diabetes, but Not Hypertension and Obesity, Is Associated with Postoperative Cognitive Dysfunction

Lachmann

Feinkohl

Borchers

et al. 2018

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…Indeed, PA is usually considered very important in many chronic diseases, reducing morbidity and mortality (Blair et al, 1989;Lee et al, 2012;Messina et al, 2017b;Polito et al, 2018;Sessa et al, 2018b). Several studies have described a positive outcome for those asthma patients who combined biologic therapy with PA: a positive correlation has been described between PA levels and lung function in asthma patients (Ritz et al, 2010;Monda et al, 2017a;Panico et al, 2017;Vanacore et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Physical Activity as a New Tool to Evaluate the Response to Omalizumab and Mepolizumab in Severe Asthmatic Patients: A Pilot Study

et al. 2020

Self Cite

View full text Add to dashboard Cite

Asthma is a chronic inflammatory airway disease, representing one of the most severe pathologies in developed countries. Based on a report of the World Health Organization (WHO), it affects about 300 million people worldwide. Few studies have analyzed the effects of daily life physical activity (PA) levels in patients with asthma: moreover, little research has been carried out on PA levels in patients suffering from severe asthma (SA). This study aimed to investigate the PA levels in two groups of patients suffering from SA; in particular, this study analyzed the changes that occur in patients treated with biologic therapy (BT group) and patients who underwent traditional treatment (TT group) over 6 months. Moreover, this study represents a pilot study because, to the best of our knowledge, it is the first investigation that analyzed if the kind of biologic drug (omalizumab or mepolizumab) can produce differences in the PA levels of SA patients. Fifty SA patients were enrolled and PA parameters were monitored for 6 months. Subjects were divided into two treatment groups: TT (20 patients) and BT (30 patients), the BT group was further subdivided according to the drugs used (15, omalizumab; 15, mepolizumab). During drug treatment, all subjects improved their PA levels: indeed, considering the intragroup variation, the PA levels were significantly higher comparing the T6 levels to baseline (T0, p < 0.01). Considering the intragroup variation, it is very interesting to note that biologic therapy improved PA levels compared to the effects of traditional therapy; while at T0 there were no significant differences in the steps per day (SPD) values between the two groups (T0, p = 0.85), the differences become statistically significant at T1, T3, and T6 (T1, p = 0.019; T3, p = 3.48x10 −6 ; T6, p = 4.78x10 −10). As expected, the same differences were reported analyzing the energy expenditure data. In

show abstract

“…Obesity can bring about the reduced volume of the brain and related diseases by declining neurogenic function, as well as increased neuronal death, oxidative stress and inflammation (3). Studies show that an increase in each unit of BMI, which is a benchmark for obesity, is associated with a decrease of 0.5% to 1.5% in the brain tissue and an increase in the atrophy of the hippocampus (4). Many studies have confirmed the relationship between obesity and reduced brain volume and consequently, mental disorders (3).…”

Section: Introductionmentioning

confidence: 99%

The Effect of High-Intensity Interval Training with and Without Caloric Restriction on Spatial Learning and Long-Term Memory of Obese Rats

Karampour

Ravasi

Choobineh

2019

Middle East J Rehabil Health Stud

View full text Add to dashboard Cite

Background: Increasing fat mass in the body reduces long-term memory (LTM) and spatial learning (SL). Objectives: The purpose of this study was to compare the effects of high-intensity interval training (HIIT) with and without caloric restriction (CR) on SL and LTM of obese rats. Methods: Forty male Sprague Dawley rats were subjected to a high-fat diet (HFD) for 12 weeks. After confirmation of obesity, they were divided into four groups of 10 subjects, including (1) training (T), (2) training + caloric restriction (T+CR), (3) CR, and (4) obese control (OC). Also, to assess the effect of obesity on the research variables, 10 rats were considered the standard control (SC) group. For 8 weeks, the rats in groups 1 and 2 performed HIIT three times per week at an intensity of 80% to 95% of Vo2max, and groups 2 and 3 received CR of 60%.

show abstract

Obesity and brain illness: from cognitive and psychological evidences to obesity paradox

Cited by 52 publications

References 110 publications

Diabetes, but Not Hypertension and Obesity, Is Associated with Postoperative Cognitive Dysfunction

Diabetes, but Not Hypertension and Obesity, Is Associated with Postoperative Cognitive Dysfunction

Physical Activity as a New Tool to Evaluate the Response to Omalizumab and Mepolizumab in Severe Asthmatic Patients: A Pilot Study

The Effect of High-Intensity Interval Training with and Without Caloric Restriction on Spatial Learning and Long-Term Memory of Obese Rats

Contact Info

Product

Resources

About