Obesity and Cancer Progression: Is There a Role of Fatty Acid Metabolism?

Balaban, Seher; Lee, Lisa S.; Schreuder, Mark; Hoy, Andrew J.

doi:10.1155/2015/274585

Cited by 89 publications

(79 citation statements)

References 207 publications

(219 reference statements)

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“…In agreement, studies in tumourbearing animals showed an increase in lipolysis and therefore an increase in the FFA release into plasma due to the hydrolysis of adipose tissue TAGs (Sakurai and Klein, 1998). Consistently, proteins that have been identified as facilitating the uptake of FAs into cells, and those involved in FA transport have also been implicated in cancer progression (Balaban et al, 2015;Guaita-Esteruelas et al, 2016). Further in support of this idea is the link between dietary FAs and breast cancer (Hsu et al, 2007).…”

Section: Circulating Free Fatty Acidsmentioning

confidence: 56%

“…Several proteins such as CD36/FAT and fatty acid-binding proteins (FABPs) have been identified to facilitate the uptake of FFAs into cells. Consistent with the idea that FFAs have a role in cancer, those FA-transport proteins have also been implicated in promoting cancer progression (Balaban et al, 2015;Guaita-Esteruelas et al, 2016). The long-chain monosaturated FFA oleate has been shown to be able to stimulate the proliferation of human breast cancer cells, with PI3K having a role in this process (Hsu et al, 2007;Hardy et al, 2005).…”

Section: Circulating Free Fatty Acidsmentioning

confidence: 73%

“…These circulating TAGs are hydrolysed by lipoprotein lipase to FFAs and then taken up into cells (Balaban et al, 2015). Several proteins such as CD36/FAT and fatty acid-binding proteins (FABPs) have been identified to facilitate the uptake of FFAs into cells.…”

Section: Circulating Free Fatty Acidsmentioning

confidence: 99%

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Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis

Saavedra‐García

Nichols

Mahmud

et al. 2018

Molecular and Cellular Endocrinology

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Keywords:Fatty acids Cancer Lipid metabolism FOXO3 FOXM1 AKT/PI3K pathway a b s t r a c t Obesity and cachexia represent divergent states of nutritional and metabolic imbalance but both are intimately linked to cancer. There is an extensive overlap in their signalling pathways and molecular components involved such as fatty acids (FAs), which likely play a crucial role in cancer. Forkhead box (FOX) proteins are responsible of a wide range of transcriptional programmes during normal development, and the FOXO3-FOXM1 axis is associated with cancer initiation, progression and drug resistance.Free fatty acids (FFAs), FA synthesis and b-oxidation are associated with cancer development and progression. Meanwhile, insulin and some adipokines, that are up-regulated by FAs, are also involved in cancer development and poor prognosis. In this review, we discuss the role of FA metabolism in cancer and how FA metabolism integrates with the FOXO3-FOXM1 axis. These new insights may provide leads to better cancer diagnostics as well as strategies for tackling cancer development, progression and drug resistance.

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Section: Circulating Free Fatty Acidsmentioning

confidence: 56%

Section: Circulating Free Fatty Acidsmentioning

confidence: 73%

See 1 more Smart Citation

Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis

Saavedra‐García

Nichols

Mahmud

et al. 2018

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

show abstract

“…The volume and composition of the adipose tissue is altered by metabolic syndrome or obesity, which may in turn influence lipid availability and utilization. While there is conflicting data on the effect of obesity on the risk of developing prostate cancer, there is now strong evidence that obese men have more aggressive disease at diagnosis and a higher rate of recurrence following surgery (reviewed in Balaban et al (2015), Taylor et al (2015)). In cell line models, lipids taken up by prostate cancer cells can drive proliferation (Nieman et al 2013) and potentially invasiveness (Sacca et al 2012).…”

Section: Androgens Stimulate Lipid Synthesis Uptake and Storagementioning

confidence: 99%

Androgen control of lipid metabolism in prostate cancer: novel insights and future applications

Butler

Centenera

Swinnen

2016

Endocrine-Related Cancer

113

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One of the most typical hallmarks of prostate cancer cells is their exquisite dependence on androgens, which is the basis of the widely applied androgen deprivation therapy. Among the variety of key cellular processes and functions that are regulated by androgens, lipid metabolism stands out by its complex regulation and its many intricate links with cancer cell biology. Here, we review our current knowledge on the links between androgens and lipid metabolism in prostate cancer, and highlight recent developments and insights into the links between key oncogenic stimuli and altered lipid synthesis and/or uptake that may hold significant potential for biomarker development and provide new vulnerabilities for therapeutic intervention.

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“…These alterations are characterized by redistribution of glucose carbons away from catabolism for ATP production toward macromolecule synthesis and maintenance of reductive capacity to sustain proliferation (Romero‐Garcia et al ., 2011). In addition to enhanced glucose and glutamine metabolism, alterations in cancer cell fatty acid (FA) metabolism have been reported (Balaban et al ., 2015). However, in general, these observations have predominantly been limited to the synthesis of new FAs from nonlipid carbon sources, that is, glucose and glutamine (Zhang and Du, 2012).…”

Section: Introductionmentioning

confidence: 99%

Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate‐induced apoptosis

et al. 2018

Self Cite

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Breast cancer (BrCa) metabolism is geared toward biomass synthesis and maintenance of reductive capacity. Changes in glucose and glutamine metabolism in BrCa have been widely reported, yet the contribution of fatty acids (FAs) in BrCa biology remains to be determined. We recently reported that adipocyte coculture alters MCF‐7 and MDA‐MB‐231 cell metabolism and promotes proliferation and migration. Since adipocytes are FA‐rich, and these FAs are transferred to BrCa cells, we sought to elucidate the FA metabolism of BrCa cells and their response to FA‐rich environments. MCF‐7 and MDA‐MB‐231 cells incubated in serum‐containing media supplemented with FAs accumulate extracellular FAs as intracellular triacylglycerols (TAG) in a dose‐dependent manner, with MDA‐MB‐231 cells accumulating more TAG. The differences in TAG levels were a consequence of distinct differences in intracellular partitioning of FAs, and not due to differences in the rate of FA uptake. Specifically, MCF‐7 cells preferentially partition FAs into mitochondrial oxidation, whereas MDA‐MB‐231 cells partition FAs into TAG synthesis. These differences in intracellular FA handling underpin differences in the sensitivity to palmitate‐induced lipotoxicity, with MDA‐MB‐231 cells being highly sensitive, whereas MCF‐7 cells are partially protected. The attenuation of palmitate‐induced lipotoxicity in MCF‐7 cells was reversed by inhibition of FA oxidation. Pretreatment of MDA‐MB‐231 cells with FAs increased TAG synthesis and reduced palmitate‐induced apoptosis. Our results provide novel insight into the potential influences of obesity on BrCa biology, highlighting distinct differences in FA metabolism in MCF‐7 and MDA‐MB‐231 cells and how lipid‐rich environments modulate these effects.

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Obesity and Cancer Progression: Is There a Role of Fatty Acid Metabolism?

Cited by 89 publications

References 207 publications

Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis

Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis

Androgen control of lipid metabolism in prostate cancer: novel insights and future applications

Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate‐induced apoptosis

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