Obesity and Cancer: the Profile of a Population who Underwent Bariatric Surgery

Brito, Helena M; Santos, Ana Cristina; Preto, John; Carvalho, Davide; Freitas, Paula

doi:10.1007/s11695-021-05626-0

Cited by 9 publications

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with this incident, a case series questions the sensitivity of preoperative ultrasonography for RCC detection in bariatric patients [ 22 ]. All in all, the number of bariatric patients with a history of malignancy or a malign diagnosis after BS will increase [ 1 ]. Unexpected intraoperative discoveries of tumors suspicious for malignancy seem to be rare.…”

Section: Discussionmentioning

confidence: 99%

“…Obesity is a complex disease state that is not only often accompanied by the classic comorbidities that constitute the metabolic syndrome, but is also associated with increased risks for autoimmune diseases and several types of cancer [ 1 , 2 ]. Severe diagnoses may therefore be uncovered in patients presenting for bariatric surgery (BS) in their preoperative evaluation, unexpectedly during surgery or in the course of postoperative follow-up.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Newly diagnosed Crohn’s disease, and hepatocellular and renal cell carcinoma in a bariatric surgery patient—dealing with the complexity of obesity-associated diseases: a case report and review of the literature

Seidemann,

Dietrich

2023

J Med Case Reports

View full text Add to dashboard Cite

Background Bariatric surgery candidates commonly suffer from conditions that constitute the metabolic syndrome. But they also have a higher risk for autoimmune and malignant diseases. Obesity-associated comorbidities aside from the metabolic syndrome are often given insufficient attention in the clinical routine, including preoperative work-ups for bariatric surgery. Case presentation We retrospectively report the case of a 65 years old Caucasian patient who was diagnosed with Crohn’s disease prior to, a hepatocellular carcinoma during, and a renal cell carcinoma post bariatric surgery. The relevance of these diseases for decision making in bariatric procedures and current recommendations for preoperative bariatric work-ups are discussed. In our case, the diagnosis of Crohn’s disease led to the performance of a sleeve gastrectomy instead of a Roux-en-Y gastric bypass and a previously unknown hepatocellular carcinoma was simultaneously removed by hepatic wedge resection. Conclusions Preoperative endoscopy and imaging techniques can be valuable since surprising pre- and intraoperative findings can force the bariatric surgeon to change the initially planned operative strategy. But the diagnostic accuracy of abdominal ultrasound may be limited in bariatric surgery patients. With the expansion of bariatric surgery, the complexity of bariatric surgery patients is also likely to increase. However, with the appropriate awareness and strategies, bariatric surgery can be safely executed and even contribute to the treatment of severe comorbidities that exceed the metabolic spectrum.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Newly diagnosed Crohn’s disease, and hepatocellular and renal cell carcinoma in a bariatric surgery patient—dealing with the complexity of obesity-associated diseases: a case report and review of the literature

Seidemann,

Dietrich

2023

J Med Case Reports

View full text Add to dashboard Cite

show abstract

“… 25 ). Obesity is now widely accepted as one of the preventable cancer risk factors in addition to tobacco smoking (Refs 26 , 27 , 28 ). Birks and colleagues (Ref.…”

Section: Obesity and Cancer Riskmentioning

confidence: 99%

Obesity-related genomic instability and altered xenobiotic metabolism: possible consequences for cancer risk and chemotherapy

Bankoglu

Stopper

2022

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

The increase in the prevalence of obesity has led to an elevated risk for several associated diseases including cancer. Several studies have investigated the DNA damage in human blood samples and showed a clear trend towards increased DNA damage in obesity. Reduced genomic stability is thus one of the consequences of obesity, which may contribute to the related cancer risk. Whether this is influenced by compromised DNA repair has not been elucidated sufficiently yet. On the other hand, obesity has also been linked to reduced therapy survival and increased adverse effects during chemotherapy, although the available data are controversial. Despite some indications that obesity might alter hepatic metabolism, current literature in humans is insufficient, and results from animal studies are inconclusive. Here we have summarised published data on hepatic drug metabolism to understand the impact of obesity on cancer therapy better. Furthermore, we highlight knowledge gaps in the interrelationship between obesity and drug metabolism from a toxicological perspective.

show abstract

“…Obesity is a complex morbid condition that is resulted from an imbalance between energy intake and energy consume 1 . It is considered a significant risk factor for several chronic and major health conditions, including cardiovascular disease, diabetes mellitus, musculoskeletal disorders, and cancer 2 .Bariatric surgery remains the most effective treatment for obesity and its complications 3 . Among the most common, are Roux en-Y bypass, sleeve gastrectomy (SG) and other types of procedures that aim to promote sustained weight loss like laparoscopic adjustable gastric banding, that result in a new hormonal weight set point can be achieved by primarily modifying the levels of gut hormones that are accountable for hunger and satiety the procedure, the majority of the stomach volume is vertically resected, removing the antrum, most of the body, and the entire fundus 7 .…”

Section: Introductionmentioning

confidence: 99%

The role of gut hormonal aspect in Iraqi patients subjected to sleeve Gastrectomy

M. Al-Amiri,

S. Kadhum,

M. Ali

2024

Baghdad Sci.J

View full text Add to dashboard Cite

ان هناك عدة انواع من العمليات الجراحية التي تجرى للاشخاص ذوي الاوزان العالية لعلاج السمنة المفرطة عندهم . وذلك عن طريق التغيير الحاصل في مستوى الهرمونات المعوية المسؤلة عن الجوع والشبع . ونتيجة لهذه العمليات سيحصل فقدان كبير بالوزن بعد اجراء الجراحة الناظورية وهو من خيارات علاج السمنة المرضية ونتيجة لذلك فأن افراز هرمون الكريلين ممكن ان يتعدل او يتغير. الهدف من الدراسة هو توضيح او اكتشاف اي تأثير لعمليات تكميم المعدة على بعض الهرمونات المعوية. لقد قمنا بأجراء دراسة مستقبلية في مركز البصرة لجراحة الأيض والسمنة ، في جنوب العراق من كانون الأول (ديسمبر) 2021 إلى آذار (مارس) 2022 ، على 24 مريضاً كانو يعانون من السمنة المرضية واجريت لهم عمليات تكميم المعدة. تم تصنيف المرضى المشمولين إلى مجموعتين رئيسيتين حسب فترات العملية. وقد عولجت النتائج باستخدام الإصدار 25 من برنامج SPSS (شركة SPSS) للحسابات الإحصائية. و قمنا بحساب قيمة P. النتائج: انخفض معدل GLP -1 و Ghrelin و Leptin و BMI بشكل ملحوظ بعد الجراحة. لم نلاحظ اي تأثير معنوي سوى علاقة ذات دلالة إحصائية واحدة بين مؤشر كتلة الجسم ومستوى اللبتين للمريض بعد ثلاثة أشهر من الجراحة ، بينما كان هناك ارتباط معنوي بين مؤشر كتلة الجسم ومستوى GLP-1 قبل الجراحة. الاستنتاج نستنتج أن الهرمونات الثلاثة GLP-1 و Ghrelin و Leptin تنخفض بعد ثلاثة أشهر من الجراحة ويزداد مؤشر كتلة الجسم بمقدار وحدة واحدة (Kg / m2) ، وسوف يزيد GLP-1 بمقدار نصف وحدة 0.45 (50٪).

show abstract

Obesity and Cancer: the Profile of a Population who Underwent Bariatric Surgery

Cited by 9 publications

References 48 publications

Newly diagnosed Crohn’s disease, and hepatocellular and renal cell carcinoma in a bariatric surgery patient—dealing with the complexity of obesity-associated diseases: a case report and review of the literature

Newly diagnosed Crohn’s disease, and hepatocellular and renal cell carcinoma in a bariatric surgery patient—dealing with the complexity of obesity-associated diseases: a case report and review of the literature

Obesity-related genomic instability and altered xenobiotic metabolism: possible consequences for cancer risk and chemotherapy

The role of gut hormonal aspect in Iraqi patients subjected to sleeve Gastrectomy

Contact Info

Product

Resources

About