Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation

Ikeda, Kouji; Morizane, Shin; Akagi, Takahiko; Hiramatsu‐Asano, Sumie; Tachibana, Koji; Yahagi, Ayano; Iseki, Masanori; Kaneto, Hideaki; Wada, Jun; Ishihara, Katsuhiko; Morita, Yoshitaka; Mukai, Tomoyuki

doi:10.3390/ijms23084312

Cited by 25 publications

(31 citation statements)

References 58 publications

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“…Saturated fatty acids intensify the inflammatory response leading to the activation of keratinocytes and macrophages. Palmitic acid has been shown to activate intracellular signaling pathways in epidermal keratinocytes, leading to increased synthesis of CCL20, CXCL8, and IL-1β [ 62 ]. The same processes can also be activated by leptin.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin, Leptin and Resistin in Patients with Psoriasis

Słuczanowska-Głąbowska

Staniszewska

Marchlewicz

et al. 2023

JCM

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Psoriasis is a common chronic, inflammatory skin disease characterised by keratinocyte hyperproliferation, parakeratosis, and T-cell infiltration. Adipose tissue has an endocrine function, producing an abundance of cytokines and adipokines. It has also been described that the major adipokines, leptin, resistin, and adiponectin, may be involved in the pathogenesis of psoriasis. The aim of the study was to examine the plasma levels of adiponectin, leptin, and resistin in patients with psoriasis and their correlations with disease activity parameters: Psoriasis Activity Severity Index (PASI), Dermatology Life Quality Index (DLQI), and Body Surface Area (BSA) index, as well as selected clinical parameters. The study included 53 patients with the plaque type and 31 healthy controls. The plasma concentrations of adiponectin were significantly lower in patients with psoriasis (p < 0.001) than in the control group. The plasma concentrations of leptin were higher in patients with psoriasis, however, due to high intra-patient variability of leptin plasma concentrations these differences did not reach statistical significance (p = 0.2). The plasma concentrations of resistin were significantly increased in patients with psoriasis compared to healthy controls (p = 0.02). There were no statistically significant correlations between adiponectin and leptin plasma concentrations and values of PASI, DLQI, and BSA. The resistin plasma concentrations correlated significantly with DLQI values. Additionally, we examined the correlations between adiponectin, leptin, and resistin plasma concentrations, and selected clinical parameters. Plasma concentrations of adiponectin correlated significantly with CRP values and ALT values. Leptin plasma concentrations correlated significantly with creatinine values. The results of our study confirm the role of adiponectin, leptin, and resistin in the pathogenesis of psoriasis.

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Section: Discussionmentioning

confidence: 99%

Adiponectin, Leptin and Resistin in Patients with Psoriasis

Słuczanowska-Głąbowska

Staniszewska

Marchlewicz

et al. 2023

JCM

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“…Many recent studies have confirmed that the production and accumulation of AGEs in diabetic patients are much higher than that in normal people, which is closely related to various complications of diabetes such as diabetic coronary heart disease, diabetic retinopathy, diabetic nephropathy, and diabetic foot. The occurrence of the diabetic foot may be related to the production of glycation end products, which can damage peripheral nerves [ 27 , 28 ], damage arteries [ 29 , 30 ], and cause skin degeneration [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Xi’s Tendon Gangrene (Nonischemic Type of Diabetic Foot) and Gangrene (Diabetic Foot Ischemic Type)

Peng¹,

Wang²,

Zhao³

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. Diabetic foot gangrene refers to a lesion in which the tissue of the foot or lower extremities of diabetic patients is damaged, and the cause is the infection of peripheral blood vessels and neuropathy caused by diabetes. Objective. To compare the related indexes of blood glucose, inflammation, blood viscosity, and peripheral neuropathy between the nonischemic diabetic foot and ischemic diabetic foot, the same and different characteristics of the two different types of diabetic foot in pathogenesis were discussed and studied. Methods. A total of 122 patients with diabetic foot were selected from the Department of Vascular Medicine, Shanghai Hospital of Integrated Traditional Chinese and Western Medicine, including 61 cases of ischemic type and 61 cases of nonischemic type. The differences in blood glucose, inflammation, blood supply, and peripheral neuropathy between the nonischemic diabetic foot and ischemic diabetic foot were compared to explore their different characteristics. Results. The blood glucose index, inflammatory index, and plasma fibrinogen in patients with nonischemic diabetic foot were significantly higher than those in patients with ischemic diabetic foot ( P < 0.05 ). The patients with ischemic diabetic foot were higher in age and blood lipid index than those with the nonischemic diabetic foot ( P < 0.05 ), while having no significant difference in platelet count, plasma viscosity, hematocrit, and end products of glycation (AGEs). Conclusion. The nonischemic diabetic foot is mainly infective necrosis, and the ischemic type is ischemic necrosis. The former occurs in the middle-aged and elderly with good blood supply between 40 and 60 years old, while the latter occurs in the elderly with the severe vascular disease over 60 years old. The blood glucose level of nonischemic patients is significantly higher than that of ischemic patients, but it has little to do with the course of diabetes.

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“…Both environmental and genetic factors are involved in the pathophysiology of psoriasis. Common environmental triggers of psoriasis involve bacterial and viral infections, stress, smoking, obesity, and probably diet [ 92 , 93 ]. Therefore, it is not surprising that several studies indicate an altered plasma lipid homeostasis, including S1P, in psoriasis patients.…”

Section: Sphingosine 1-phosphate and Inflammatory Skin Diseasesmentioning

confidence: 99%

Sphingosine 1-Phosphate as Essential Signaling Molecule in Inflammatory Skin Diseases

Kleuser

Bäumer

2023

IJMS

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Sphingolipids are crucial molecules of the mammalian epidermis. The formation of skin-specific ceramides contributes to the formation of lipid lamellae, which are important for the protection of the epidermis from excessive water loss and protect the skin from the invasion of pathogens and the penetration of xenobiotics. In addition to being structural constituents of the epidermal layer, sphingolipids are also key signaling molecules that participate in the regulation of epidermal cells and the immune cells of the skin. While the importance of ceramides with regard to the proliferation and differentiation of skin cells has been known for a long time, it has emerged in recent years that the sphingolipid sphingosine 1-phosphate (S1P) is also involved in processes such as the proliferation and differentiation of keratinocytes. In addition, the immunomodulatory role of this sphingolipid species is becoming increasingly apparent. This is significant as S1P mediates a variety of its actions via G-protein coupled receptors. It is, therefore, not surprising that dysregulation in the signaling pathways of S1P is involved in the pathophysiological conditions of skin diseases. In the present review, the importance of S1P in skin cells, as well as the immune cells of the skin, is elaborated. In particular, the role of the molecule in inflammatory skin diseases will be discussed. This is important because interfering with S1P signaling pathways may represent an innovative option for the treatment of inflammatory skin diseases.

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Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation

Cited by 25 publications

References 58 publications

Adiponectin, Leptin and Resistin in Patients with Psoriasis

Adiponectin, Leptin and Resistin in Patients with Psoriasis

A Comparative Study of Xi’s Tendon Gangrene (Nonischemic Type of Diabetic Foot) and Gangrene (Diabetic Foot Ischemic Type)

Sphingosine 1-Phosphate as Essential Signaling Molecule in Inflammatory Skin Diseases

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