Obesity and Endometrial Cancer

Sağnıç, Saliha

doi:10.5772/intechopen.99827

Cited by 2 publications

(3 citation statements)

References 73 publications

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“…The majority of patients were diagnosed in the age group of 40-59 years, followed by those aged 60 years and above and those aged 40 years and below. This is consistent with the literature, which suggests that uterine cancer is more common in postmenopausal women [ 17 , 6 ]. The average age at diagnosis in this study is 53.9 years.…”

Section: Discussionsupporting

confidence: 93%

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Epidemiology of Uterine Cancer in Sarawak, Borneo, A 20-Year Review

Jawa,

Wong,

Wahab

et al. 2024

Asian Pac J Cancer Prev

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Objective: This study aimed to determine the epidemiology of uterine cancer in Sarawak, Malaysia, using data from a population-based cancer registry. Methods: The study population included all women diagnosed with uterine cancer in Sarawak, Malaysia between January 1996 and December 2015. Data on demographic and clinical characteristics were obtained from the Sarawak Cancer Registry. The crude incidence rate, age-standardized incidence rate (ASR), and incidence risk ratios (IRR) were calculated. Joinpoint regression analyses were performed to assess trends in incidence rates. Results: A total of 811 women were diagnosed with primary uterine cancer during the study period. The overall crude incidence rate for uterine cancer in Sarawak for the period 1996-2015 was 3.7 per 100,000. The ASR was 4.4 per 100,000 with a 95% CI (4.1-4.8). The ASR in 2011-2015 is 1.6 times higher than the ASR of uterine cancer in 1996-2000. Higher incidence rates were observed in women aged 40-59 years and those aged 60 years and above. Chinese women had the highest ASR, followed by Malay and Iban women. Joinpoint regression analyses showed a significant increase in cases of uterine cancer among all ethnic groups and age groups. Conclusion: The incidence of primary uterine cancer in Sarawak, Malaysia, has increased over the past 20 years, with higher incidence rates observed in older age groups and among Chinese women. The findings suggest the need for continued efforts to improve the prevention, early detection, and treatment of uterine cancer in Sarawak.

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Section: Discussionsupporting

confidence: 93%

“…Women in families with an inherited form of bowel cancer (known as Lynch syndrome) have an increased risk of uterine cancer. A history of polycystic ovary syndrome, a condition characterised by infertility, enlarged ovaries and menstrual problems, also increases the risk [ 6 - 8 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Uterine Cancer in Sarawak, Borneo, A 20-Year Review

Jawa,

Wong,

Wahab

et al. 2024

Asian Pac J Cancer Prev

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“…A review of literature conducted by the International Agency for Research on Cancer (IARC) has established a link between BAI and endometrial cancer. The review further explains that a higher BMI accounts for 35% of endometrial cancer cases [ 131 ], which further supports evidence of a dose–response relationship between obesity and EC as indicated in a 2015 review [ 132 ]. In a review conducted by MacKintosh and Crosbie in 2013, the inter-dependency of obesity and EC was confirmed.…”

Section: Introductionsupporting

confidence: 64%

Exploring the Potential Link between PFAS Exposure and Endometrial Cancer: A Review of Environmental and Sociodemographic Factors

Ayodele,

Obeng-Gyasi

2024

Cancers

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This exploratory narrative review paper delves into the intricate interplay between per- and polyfluoroalkyl substances (PFAS) exposure, sociodemographic factors, and the influence of stressors in the context of endometrial cancer. PFAS, ubiquitous environmental contaminants notorious for their persistence in the ecosystem, have garnered attention for their potential to disrupt endocrine systems and provoke immune responses. We comprehensively examine the various sources of PFAS exposure, encompassing household items, water, air, and soil, thus shedding light on the multifaceted routes through which individuals encounter these compounds. Furthermore, we explore the influence of sociodemographic factors, such as income, education, occupation, ethnicity/race, and geographical location and their relationship to endometrial cancer risk. We also investigated the role of stress on PFAS exposure and endometrial cancer risk. The results revealed a significant impact of sociodemographic factors on both PFAS levels and endometrial cancer risk. Stress emerged as a notable contributing factor influencing PFAS exposure and the development of endometrial cancer, further emphasizing the importance of stress management practices for overall well-being. By synthesizing evidence from diverse fields, this review underscores the need for interdisciplinary research and targeted interventions to comprehensively address the complex relationship between PFAS, sociodemographic factors, stressors, and endometrial cancer.

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Obesity and Endometrial Cancer

Cited by 2 publications

References 73 publications

Epidemiology of Uterine Cancer in Sarawak, Borneo, A 20-Year Review

Epidemiology of Uterine Cancer in Sarawak, Borneo, A 20-Year Review

Exploring the Potential Link between PFAS Exposure and Endometrial Cancer: A Review of Environmental and Sociodemographic Factors

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