Obesity and endometrial cancer: the role insulin resistance and adipokines

Tzenios, Nikolaos; Chahine, Mohamad; Tazanios, Mary

doi:10.58676/sjmas.v1i2.12

Cited by 8 publications

(10 citation statements)

References 18 publications

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“…In addition, the use of combined oral contraceptives protects against EAC for about 30 years 34 . The mechanisms of obesity‐induced EAC are not fully elucidated, though adipose‐derived estrogen, which is unopposed by progesterone in postmenopausal obese women could be the potential mechanism 35 . Besides, T2DM and IR promote the development of EAC due to dysregulation of insulin signaling and adipocytokines 36 .…”

Section: Furin and Cardiometabolic Disordersmentioning

confidence: 99%

The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review

Al‐kuraishy,

Al‐Maiahy,

Al‐Gareeb

et al. 2023

Cancer Reports

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BackgroundEndometrial adenocarcinoma (EAC) is a malignant tumor of the endometrium. EAC is the most common female malignancy following the menopause period. About 40% of patients with EAC are linked with obesity and interrelated with hypertension, diabetes mellitus, and high circulating estrogen levels. Proprotein convertase (PC) furin was involved in the progression of EAC.Recent findingsFurin is a protease enzyme belonging to the subtilisin PC family called PC subtilisin/kexin type 3 that converts precursor proteins to biologically active forms and products. Aberrant activation of furin promotes abnormal cell proliferation and the development of cancer. Furin promotes angiogenesis, malignant cell proliferation, and tissue invasion by malignant cells through its pro‐metastatic and oncogenic activities. Furin activity is correlated with the malignant proliferation of EAC. Higher expression of furin may increase the development of EAC through overexpression of pro‐renin receptors and disintegrin and metalloprotease 17 (ADAM17). As well, inflammatory signaling in EAC promotes the expression of furin with further propagation of malignant transformation.ConclusionFurin is associated with the development and progression of EAC through the induction of proliferation, invasion, and metastasis of malignant cells of EAC. Furin induces ontogenesis in EAC through activation expression of ADAM17, pro‐renin receptor, CD109, and TGF‐β. As well, EAC‐mediated inflammation promotes the expression of furin with further propagation of neoplastic growth and invasion.

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Section: Furin and Cardiometabolic Disordersmentioning

confidence: 99%

The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review

Al‐kuraishy,

Al‐Maiahy,

Al‐Gareeb

et al. 2023

Cancer Reports

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“…It calls for continued investment in research, education, and technological integration to ensure that healthcare systems remain resilient, patient-centered, and well-equipped to navigate the critical care scenarios of the future. [20].…”

Section: Safety and Error Reductionmentioning

confidence: 99%

Advancements in Emergency Medicine: Innovations and Challenges in Critical Care

William

2023

Preprint

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“…Moreover, an increased body adiposity index (BAI) has been found to raise the risk of cancer-related mortality [ 130 ]. A review of literature conducted by the International Agency for Research on Cancer (IARC) has established a link between BAI and endometrial cancer.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Potential Link between PFAS Exposure and Endometrial Cancer: A Review of Environmental and Sociodemographic Factors

Ayodele,

Obeng-Gyasi

2024

Cancers

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This exploratory narrative review paper delves into the intricate interplay between per- and polyfluoroalkyl substances (PFAS) exposure, sociodemographic factors, and the influence of stressors in the context of endometrial cancer. PFAS, ubiquitous environmental contaminants notorious for their persistence in the ecosystem, have garnered attention for their potential to disrupt endocrine systems and provoke immune responses. We comprehensively examine the various sources of PFAS exposure, encompassing household items, water, air, and soil, thus shedding light on the multifaceted routes through which individuals encounter these compounds. Furthermore, we explore the influence of sociodemographic factors, such as income, education, occupation, ethnicity/race, and geographical location and their relationship to endometrial cancer risk. We also investigated the role of stress on PFAS exposure and endometrial cancer risk. The results revealed a significant impact of sociodemographic factors on both PFAS levels and endometrial cancer risk. Stress emerged as a notable contributing factor influencing PFAS exposure and the development of endometrial cancer, further emphasizing the importance of stress management practices for overall well-being. By synthesizing evidence from diverse fields, this review underscores the need for interdisciplinary research and targeted interventions to comprehensively address the complex relationship between PFAS, sociodemographic factors, stressors, and endometrial cancer.

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Obesity and endometrial cancer: the role insulin resistance and adipokines

Cited by 8 publications

References 18 publications

The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review

The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review

Advancements in Emergency Medicine: Innovations and Challenges in Critical Care

Exploring the Potential Link between PFAS Exposure and Endometrial Cancer: A Review of Environmental and Sociodemographic Factors

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