Obesity and fat quantification in lean tissues using three-point Dixon MR imaging

Kovanlıkaya, Arzu; Mittelman, Steven D.; Ward, A.; Geffner, Mitchell E.; Dorey, Frederick J.; Gilsanz, Vicente

doi:10.1007/s00247-005-1413-y

Cited by 94 publications

(93 citation statements)

References 30 publications

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“…Our observation of significant correlation between liver and pancreas fat content according to MRI (r = 0.43, P < 0.01) is also in disagreement with a recent study involving a smaller number of volunteers than we included here (17 vs 36) [10] , and with another small study (n = 15) in which the existence of significant correlation between liver and pancreas fat content is not mentioned [8] . The small scale of both earlier studies in humans probably explains their failure to demonstrate the correlation between the fat content in liver and pancreas.…”

Section: Discussioncontrasting

confidence: 99%

“…The small scale of both earlier studies in humans probably explains their failure to demonstrate the correlation between the fat content in liver and pancreas. The presence of such a correlation does fit a previous demonstration that obese nondiabetic subjects have increased fat in the pancreas [8] . It is also in line with a notion that lipomatosis of the pancreas reflects early events in the pathogenesis of diabetes [9] , confirming what has been shown in numerous publications dealing with the fattening of the liver.…”

Section: Discussionsupporting

confidence: 84%

“…liver (steatohepatitis and cirrhosis) [6] dysfunction) [7] and lipotoxicity of the kidney [4] . Whereas liver steatosis has been quantified in dozens of magnetic resonance imaging (MRI) studies, and pancreatic lipomatosis [8][9][10] and muscle fattening [8][9][10][11] in some, quantitative documentation of the content of fat in human kidneys in situ appears to be lacking entirely. In rats, however, steatosis of the kidney was recently associated with an alteration in renal acidification [12] .…”

Section: Introductionmentioning

confidence: 99%

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MRI-determined fat content of human liver, pancreas and kidney

Sijens

Edens

Bakker

et al. 2010

WJG

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AIM:To assess and correlate the lipid content of various organs in obese subjects and in persons with a normal body weight. METHODS:Magnetic resonance spectroscopy and a previously validated gradient echo magnetic resonance imaging method with Dixon's two point technique were used in this study to quantify fat in liver, pancreas as well as kidney. RESULTS:In 36 volunteers with body mass index (BMI) ranging from 20.0 to 42.9 kg/m 2 , the median fat content of liver, pancreas and kidney was 2.3% (interquartile range: 0.2%-7.8%), 2.7% (1.0%-6.5%) and 0.7% (0.1%-1.4%), respectively. BMI and subcutaneous fat correlated significantly with liver and pancreas fat content. We show for the first time the significant correlation of liver and pancreas fat content in healthy controls (r = 0.43, P < 0.01). These observations are related to body weight as measured by BMI and the amount of subcutaneous fat. Kidney fat content is very low and correlates with none of the other fat depots. CONCLUSION:Renal lipid accumulation, unlike the coupled accumulations of fat in liver and pancreas, is not observed in obese subjects. Unlike suggestions made in previous studies, renal lipid accumulation appears not to be involved in the pathogenesis of renal disease in humans.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

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MRI-determined fat content of human liver, pancreas and kidney

Sijens

Edens

Bakker

et al. 2010

WJG

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“…Water/fat imaging has also shown potential in vitro to accurately measure FFs below 1 % (19,22), and has recently been used for measurements of muscular fat in vivo (4,23).…”

Section: Fat Quantification In Skeletal Muscle Using Multigradient-ecmentioning

confidence: 99%

Fat quantification in skeletal muscle using multigradient-echo imaging: Comparison of fat and water references

Peterson

Romu

Brorson

et al. 2015

J. Magn. Reson. Imaging

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Fat quantification in skeletal muscle using multigradient-echo imaging: Comparison of fat and water references. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal 1 Fat quantification in skeletal muscleFat quantification in skeletal muscle using multigradient-echo imaging: comparison of fat and water references 2 Fat quantification in skeletal muscle AbstractPurpose: To compare the precision, accuracy, and repeatability of water/fat imaging-based fat quantification in muscle tissue using small or large flip angles (FAs), and a water or fat reference for calculation of the proton density fat fraction (FF). Materials and methods:An Intralipid phantom and both forearms of six patients suffering from lymphedema and ten healthy volunteers were investigated in a 1.5T scanner. Two multigradient-echo sequences with eight echo times and FAs of 10° and 85° were acquired, respectively. For healthy volunteers, the acquisition of the right arm was performed twice with repositioning. From each set, water reference FF and fat reference FF images were reconstructed and the average FF and the standard deviation were calculated within the subfascial compartment. The small FA water reference was considered the reference standard.Results: The use of a fat reference effectively avoided bias due to T 1 weighting when using a large FA. The large FA fat reference approach also resulted in the highest precision, but no significant difference in repeatability between the various methods was detected. Conclusion:The precision of fat quantification in muscle tissue can be increased with maintained accuracy using a larger flip angle, if a fat reference instead of a water reference is used.

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“…İn-phase, out-of-phase gibi bazı MR teknikleri ile pankreas lipid ölçümü yapılabilir (50,51). T1 ve T2 ağırlıklı sekanslarda steatotik pankreas karaciğere göre daha parlak izlenirken; out-ofphase sekanslarda ise sinyal kaybı gözlenir.…”

Section: Fi̇zyopatoloji̇ Eti̇yoloji̇ Ve Kli̇ni̇kunclassified

Pancreatic steatosis: diagnosis and clinical significance

Dağdeviren

Altay

Nalbant

2017

Journal of Contemporary Medicine

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Pancreatic steatosis (PS), with increased use of abdominal imaging in recent years generally appears as incidental. But it is a condition that is often overlooked. The reason for this is not yet fully demonstrated the clinical significance of PS while. However, in recent years, there are some studies conducted on the relationship with ps and other disease such as diabetes, metabolic syndrome, acute and chronic pancreatitis and pancreatic cancer. In this review, the etiology, diagnosis, treatment and clinical characteristics of ps were evaluated in the light of recent literature and current approache

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Obesity and fat quantification in lean tissues using three-point Dixon MR imaging

Abstract: We conclude that in nondiabetic teenagers, obesity is associated with an increased accumulation of fat in the pancreas without impairment of insulin secretion.

Cited by 94 publications

References 30 publications

MRI-determined fat content of human liver, pancreas and kidney

MRI-determined fat content of human liver, pancreas and kidney

Fat quantification in skeletal muscle using multigradient-echo imaging: Comparison of fat and water references

Pancreatic steatosis: diagnosis and clinical significance

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