Obesity and frontal‐striatal brain structures in offspring of individuals with bipolar disorder: Results from the global mood and brain science initiative

Mansur, Rodrigo B.; McIntyre, Roger S.; Cao, Bo; Lee, Yena; Japiassú, Letícia; Chen, Kun; Lu, Rui; Lu, Weicong; Chen, Xiao; Li, Ting; Xu, Gaixia; Lin, Kangguang

doi:10.1111/bdi.12559

Cited by 14 publications

(17 citation statements)

References 53 publications

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“…The current study forms part of the ongoing Recognition and Early Intervention on Prodromal BDs project, initiated by the Global Mood and Brain Science Initiative (Lin et al, 2015;Lin et al, 2017;Mansur et al, 2018;McIntyre et al, 2017). This study was approved by the Institutional Review Board of the Guangzhou Brain Hospital.…”

Section: Participantsmentioning

confidence: 99%

Aberrant brain structural–functional connectivity coupling in euthymic bipolar disorder

Zhang

Shao

et al. 2019

Human Brain Mapping

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Aberrant structural (diffusion tensor imaging [DTI]) and resting‐state functional magnetic resonance imagining connectivity are core features of bipolar disorder. However, few studies have explored the integrity agreement between structural and functional connectivity (SC–FC) in bipolar disorder. We examine SC connectivity coupling index whether could potentially provide additional clinical predictive value for bipolar disorder spectrum disorders besides the intramodality network measures. By examining the structural (DTI) and resting‐state functional network properties, as well as their coupling index, among 57 euthymic bipolar disorder patients (age 13–28 years, 18 females) and 42 age‐ and gender‐matched healthy controls (age 13–28 years, 16 females), we found that compared to controls, bipolar disorder patients showed increased structural rich‐club connectivity as well as decreased functional modularity. Importantly, the coupling strength between structural and functional connectome was decreased in patients compared to controls, which emerged as the most powerful feature discriminating the two groups. Our findings suggest that structural–functional coupling strength could serve as a valuable biological trait‐like feature for bipolar disorder over and above the intramodality network measures. Such measure can have important clinical implications for early identification of bipolar disorder individuals, and inform strategies for prevention of bipolar disorder onset and relapse.

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Section: Participantsmentioning

confidence: 99%

Aberrant brain structural–functional connectivity coupling in euthymic bipolar disorder

Zhang

Shao

et al. 2019

Human Brain Mapping

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“…Replicated evidence suggests that the metabolic–immunoinflammatory interface is a critical moderator of the differential effects of obesity on individuals with a neuropsychiatric illness. 10 – 13 …”

Section: Introductionmentioning

confidence: 99%

“…The hypothesis of our study was that the main cause of obesity was due to metabolic problems, which may lead to changes in nerve fibers. 10 – 13 Obesity was thought to be associated with dopaminergic pathways that can regulate rewarding processes. 14 Therefore, when dopamine receptor decreased, it will reduce the sensitivity to natural rewards.…”

Section: Introductionmentioning

confidence: 99%

Brain structural networks and connectomes: the brain–obesity interface and its impact on mental health

Chen¹,

Liu²,

Chao³

et al. 2018

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PurposeObesity is a complex and multifactorial disease identified as a global epidemic. Convergent evidence indicates that obesity differentially influences patients with neuropsychiatric disorders providing a basis for hypothesizing that obesity alters brain structure and function associated with the brain’s propensity toward disturbances in mood and cognition. Herein, we characterize alterations in brain structures and networks among obese subjects (ie, body mass index [BMI] ≥30 kg/m2) when compared with non-obese controls.Patients and methodsWe obtained noninvasive diffusion tensor imaging and generalized q-sampling imaging scans of 20 obese subjects (BMI=37.9±5.2 SD) and 30 non-obese controls (BMI=22.6±3.4 SD). Graph theoretical analysis and network-based statistical analysis were performed to assess structural and functional differences between groups. We additionally assessed for correlations between diffusion indices, BMI, and anxiety and depressive symptom severity (ie, Hospital Anxiety and Depression Scale total score).ResultsThe diffusion indices of the posterior limb of the internal capsule, corona radiata, and superior longitudinal fasciculus were significantly lower among obese subjects when compared with controls. Moreover, obese subjects were more likely to report anxiety and depressive symptoms. There were fewer structural network connections observed in obese subjects compared with non-obese controls. Topological measures of clustering coefficient (C), local efficiency (Elocal), global efficiency (Eglobal), and transitivity were significantly lower among obese subjects. Similarly, three sub-networks were identified to have decreased structural connectivity among frontal–temporal regions in obese subjects compared with non-obese controls.ConclusionWe extend knowledge further by delineating structural interconnectivity alterations within and across brain regions that are adversely affected in individuals who are obese.

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“…Effects of group status and BMI on brain volumes are described elsewhere . After adjustment for age and intracranial volume (ICV), BDNF levels were negatively associated with the left pars orbitalis (r = ‐0.268, P = 0.012) and left pars triangularis volumes (r = ‐0.238, P = 0.025).…”

Section: Resultsmentioning

confidence: 99%

BDNF and BMI effects on brain structures of bipolar offspring: results from the global mood and brain science initiative

Mansur

Brietzke

McIntyre

et al. 2017

Acta Psychiatr Scand

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Obesity and frontal‐striatal brain structures in offspring of individuals with bipolar disorder: Results from the global mood and brain science initiative

Abstract: Alterations in brain structures in individuals at risk for BD may be moderated by BMI. Obesity among individuals with a family history of BD may confer additional risk, particularly in mid-adolescence.

Cited by 14 publications

References 53 publications

Aberrant brain structural–functional connectivity coupling in euthymic bipolar disorder

Aberrant brain structural–functional connectivity coupling in euthymic bipolar disorder

Brain structural networks and connectomes: the brain–obesity interface and its impact on mental health

BDNF and BMI effects on brain structures of bipolar offspring: results from the global mood and brain science initiative

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Obesity and frontal‐striatal brain structures in offspring of individuals with bipolar disorder: Results from the global mood and brain science initiative

Abstract: Alterations in brain structures in individuals at risk for BD may be moderated by BMI. Obesity among individuals with a family history of BD may confer additional risk, particularly in mid-adolescence.

Cited by 14 publications

References 53 publications

Aberrant brain structural–functional connectivity coupling in euthymic bipolar disorder

Aberrant brain structural–functional connectivity coupling in euthymic bipolar disorder

Brain structural networks and connectomes: the brain&ndash;obesity interface and its impact on mental health

BDNF and BMI effects on brain structures of bipolar offspring: results from the global mood and brain science initiative

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Brain structural networks and connectomes: the brain–obesity interface and its impact on mental health