Obesity and immune cells in Saudi females

Alsufyani, Amal Abdulaziz; Mahassni, Sawsan Hassan

doi:10.1177/1753425910372536

Cited by 16 publications

(19 citation statements)

References 18 publications

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“…In two studies, an increased absolute basophil count (26,60) and basophils' percentage of total WBC (60) were reported to correlate with higher BMI. In contrast, others reported no correlation between basophil counts and BMI, and no difference between the obesity groups among female students (62). Additionally, in crosssectional studies on healthy middle-aged men (24,63) and women (63), diabetic persons (16,24) and persons with cardiovascular risk (16), higher basophil counts were not associated with either MetS prevalence (16,63) (while all other leucocytes classes did) (16), or the number of the MetS criteria (24,63).…”

Section: Other Granulocytes: Circulating Basophils and Eosinophilsmentioning

confidence: 94%

“…Higher CD3+ T cell counts were demonstrated to associate with MetS and with specific MetS risk factors (higher TG, lower HDL) (78) and to correlate with the number of MetS risk factors in men (24,78). On the other hand, CD3+ T cell counts were increased only in obese, but not in morbidly obese, compared with lean persons (22), were similar among obese and non-obese children (79) and adults (25), and did not correlate with BMI in female students (62). Furthermore, CD3+ T cells percentage was the same between obese, lean and formerly obese women after gastric banding surgery (80), and was even decreased (by ∼20%) in obese compared with lean persons in one study (31).…”

Section: Total Circulating Lymphocyte Countsmentioning

confidence: 98%

“…Nevertheless, leptin receptor on human basophils was found to mediate enhanced survival, migration, activation (CD63 levels), degranulation and cytokine synthesis (59), suggesting a role for obesity-associated hyper-leptinaemia in circulating basophils' activation state. In the circulation, basophil counts were reported to either associate with BMI/MetS (26,60,61), not associate (16,24,62,63) or to even negatively associate with it (64): positive associations in both men and women were observed between basophil counts and the presence of the MetS after adjusting for age, smoking, alcohol intake, education level and household income. Yet, the association was lost when other leucocyte counts (total WBC, neutrophils, lymphocytes, eosinophils and monocytes) were included in the model (61).…”

Section: Other Granulocytes: Circulating Basophils and Eosinophilsmentioning

confidence: 99%

“…Table 3, ii). Circulating T CD4+ cell counts were reported to be elevated in morbidly obese (60,76,82,84), obese (22,62,80,84), and in overweight (84) compared with lean persons, and to correlate with BMI (76,82). CD4+ T cells also showed correlations with waist-to-hip ratio (WHR) in female students (62) and with adiposity (percent body fat) in children (46).…”

Section: T Cells Subpopulations: Circulating Cd8+ Ctl (Table 3 I)mentioning

confidence: 99%

“…Circulating T CD4+ cell counts were reported to be elevated in morbidly obese (60,76,82,84), obese (22,62,80,84), and in overweight (84) compared with lean persons, and to correlate with BMI (76,82). CD4+ T cells also showed correlations with waist-to-hip ratio (WHR) in female students (62) and with adiposity (percent body fat) in children (46). Relating to obesity-associated cardio-metabolic morbidity, CD4+ T cell counts were reported to correlate with insulin sensitivity (fasting insulin levels and glucose-to-insulin ratio) in non-diabetic morbid obese women (76), and in men with increased prevalence of MetS, specific MetS parameters (hypertension, high TG, low HDL) and with the number of positive MetS criteria (78).…”

Section: T Cells Subpopulations: Circulating Cd8+ Ctl (Table 3 I)mentioning

confidence: 99%

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Peripheral blood leucocyte subclasses as potential biomarkers of adipose tissue inflammation and obesity subphenotypes in humans

et al. 2013

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While obesity is clearly accepted as a major risk factor for cardio-metabolic morbidity, it is also apparent that some obese patients largely escape this association, forming a unique obese subphenotype(s). Current approaches to define such subphenotypes include clinical biomarkers that largely reflect already manifested comorbidities, such as markers of dyslipidaemia, hyperglycaemia and impaired regulation of vascular tone, and anthropometric or imaging-based assessment of adipose tissue distribution. Low-grade inflammation, evident both systemically and within adipose tissue (particularly intra-abdominal fat depots), seems to characterize the more cardio-metabolically morbid forms of obesity. Indeed, several systemic inflammatory markers (C-reactive protein), adipokines (retinol-binding protein 4, adiponectin) and cytokines have been shown to correlate in humans with adipose tissue inflammation and with obesity-associated health risks. Circulating leucocytes constitute a diverse group of cells that form a major arm of the immune system. They are both major sources of cytokines and likely also of infiltrating adipose tissue immune cells in obesity. In the present review, we summarize currently available literature on 'classical' blood white cell classes and on more specific leucocyte subclasses present in the circulation in human obesity. We critically raise the possibility that leucocytes may constitute clinically available markers for the more morbidity-associated obesity subphenotype(s), and when available, for intra-abdominal adipose tissue inflammation.

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Section: Other Granulocytes: Circulating Basophils and Eosinophilsmentioning

confidence: 94%

Section: Total Circulating Lymphocyte Countsmentioning

confidence: 98%

Section: Other Granulocytes: Circulating Basophils and Eosinophilsmentioning

confidence: 99%

Section: T Cells Subpopulations: Circulating Cd8+ Ctl (Table 3 I)mentioning

confidence: 99%

Section: T Cells Subpopulations: Circulating Cd8+ Ctl (Table 3 I)mentioning

confidence: 99%

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Peripheral blood leucocyte subclasses as potential biomarkers of adipose tissue inflammation and obesity subphenotypes in humans

et al. 2013

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T-cell profile and systemic cytokine levels in overweight-obese patients with moderate to very-severe COPD

Peres

Dorneles

Dias

et al. 2018

Respiratory Physiology & Neurobiology

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This study aimed to evaluate the immune profile of lean and overweight-obese COPD patients. Forty patients with moderate to very severe COPD were divided into lean group (n=20; aged 62.00±8.91years; BMI 22.26±1.65kg/m) or overweight-obese group (n=20; aged 65.40±6.69years; BMI 29.19±3.55kg/m). The cytokine profile (IL-2, IL-4, IL-6, IL-10, INF-γ, and TNF-α) was evaluated through the Cytometric Bead Array technique, and the expression of CD4, CD8, CD25, CD45ra, CD45ro, CD69, CD195(CCr5) and HLA-DR were evaluated in CD3+ T-cells. Overweight-obese COPD group had lower levels of IL-2 (p=0.01) and higher INF-γ levels (p=0.02) and IL-6 (p=0.003) than lean COPD. Lean COPD patients had higher CD25+ (p=0.01), CCr5 (p=0.04) and HLA-DR (p=0.007) expression on T cell surface compared to overweight-obese COPD participants. These changes are related to immune dysfunction of obesity, and excess of fat mass in COPD can be a key factor to low T-cells activation.

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Heritability and GWAS Studies for Monocyte–Lymphocyte Ratio

et al. 2017

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The monocyte-lymphocyte ratio (MLR) is a useful biomarker for disease development, but little is known about the extent to which genetic and environmental factors influence MLR variation. Here, we study the genetic architecture of MLR and determine the influence of demographic and lifestyle factors on MLR in data from a Dutch non-patient twin-family population. Data were obtained in 9,501 individuals from the Netherlands Twin Register. We used regression analyses to determine the effects of age, sex, smoking, and body mass index (BMI) on MLR and its subcomponents. Data on twins, siblings and parents (N = 7,513) were analyzed by genetic structural equation modeling to establish heritability and genome wide single nucleotide polymorphism (SNP) data from a genotyped subsample (N = 5,892) and used to estimate heritability explained by SNPs. SNP and phenotype data were also analyzed in a genome-wide association study to identify the genes involved in MLR. Linkage disequilibrium (LD) score regression and expression quantitative trait loci (eQTL) analyses were performed to further explore the genetic findings. Results showed that age, sex, and age × sex interaction effects were present for MLR and its subcomponents. Variation in MLR was not related to BMI, but smoking was positively associated with MLR. Heritability was estimated at 40% for MLR, 58% for monocyte, and 58% for lymphocyte count. The Genome-wide association study (GWAS) identified a locus on ITGA4 that was associated with MLR and only marginally significantly associated with monocyte count. For monocyte count, additional genetic variants were identified on ITPR3, LPAP1, and IRF8. For lymphocyte count, GWAS provided no significant findings. Taking all measured SNPs together, their effects accounted for 13% of the heritability of MLR, while all known and identified genetic loci explained 1.3% of variation in MLR. eQTL analyses showed that these genetic variants were unlikely to be eQTLs. In conclusion, variation in MLR level in the general population is heritable and influenced by age, sex, and smoking. We identified gene variants in the ITGA4 gene associated with variation in MLR. The significant SNP-heritability indicates that more genetic variants are likely to be involved.

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Obesity and immune cells in Saudi females

Cited by 16 publications

References 18 publications

Peripheral blood leucocyte subclasses as potential biomarkers of adipose tissue inflammation and obesity subphenotypes in humans

Peripheral blood leucocyte subclasses as potential biomarkers of adipose tissue inflammation and obesity subphenotypes in humans

T-cell profile and systemic cytokine levels in overweight-obese patients with moderate to very-severe COPD

Heritability and GWAS Studies for Monocyte–Lymphocyte Ratio

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