Obesity and Insulin Resistance in Childhood

Pastucha, Dalibor; Malinčíková, Jana; Hyjánek, Jiří; Horáková, D; Čížek, Luděk; Janoutová, Gabriela; Janout, Vladimí­r

doi:10.21101/cejph.a3437

Cited by 12 publications

(9 citation statements)

References 7 publications

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“…In reality, index QUICKI which has narrower confidence intervals and hence less variability may be more useful 1,11 . Healthy children have values of QUICKI index around 0.29.…”

Section: Discussionmentioning

confidence: 99%

“…One of the most common nutritional disorder worldwide, affecting virtually both developed and developing countries of all socio-economic groups, irrespective of age, sex or ethnicity, clearly associated with the metabolic syndrome, condition with implications for the development of many chronic diseases as obesity and hypertension, type 2 diabetes mellitus, dyslipidemia, obstructive sleep apnoe, and orthopedic problems. In the Czech Republic, childhood obesity is now a serious epidemiological problem: 20% of children aged [6][7][8][9][10][11][12] and 11% of children aged 13-17 years are already overweight or obese. These data were provided by the study of the Czech Obesity Association entitled "Life Style and…”

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confidence: 99%

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Obesity, Hypertension and Insulin Resistance in Childhood - A Pilot Study

Pastucha¹,

Talafa²,

Malinčíková³

et al. 2010

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Key words: Obesity in children/Insulin resistance/Hypertension in children/HOMA/QUICKIBackground. Obesity and arterial hypertension are a serious risk factor for insulin resistance patients leading to diabetes and other disorders. Obesity is one of the most common nutritional problems in developed countries. Actually the incidence of obesity is increasing considerably, obesity is emerging in alarming rates between the last 10 years. Obesity and hypertension beginning in childhood often precedes the hyperinsulinemic state. The metabolic syndrome is rapidly increasing in prevalence with rising childhood obesity and sedentary lifestyles worldwide. The aim of this study was to compare average levels of the homeostatic indices HOMA and QUICKI in obese children compared to healthy and hypertonic children in order to find convenient markers for insulin sensitivity in clinical pediatric practice.Methods. 49 obese children (11 girls, 38 boys), 42 children healthy (33 boys and 9 girls) and 37 hypertensive children (4 girls, 33 boys) were selected.Results. The average level of HOMA in obese children was 4.58; in healthy children 1.8 and in the group of hypertonic children the level was 2.75. The average level of QUICKI in obese children was 0.22; in healthy children 0.29 and in hypertonic children 0.28.Conclusions. The results demonstrate the possibility of insulin sensitivity assessment using these indices in pediatric practice. QUICKI has a narrower confidence interval and thus a lower variability. QUICKI an HOMA indexes are useful predominantly for epidemiological purposes, mainly for maping the scope of insulinoresistance among children.gest that the prevalence of elevated blood pressure could have increased in children over the last few decades. Obesity itself needs not always mean overweight but an accumulation of fatty tissue. In childhood, it is obvious that the continuous increase in weight is not merely caused by the increase of fat tissue but also by the development of the body frame and the muscle mass. The share of this component differs according to the individual age group and gender.Obesity. One of the most common nutritional disorder worldwide, affecting virtually both developed and developing countries of all socio-economic groups, irrespective of age, sex or ethnicity, clearly associated with the metabolic syndrome, condition with implications for the development of many chronic diseases as obesity and hypertension, type 2 diabetes mellitus, dyslipidemia, obstructive sleep apnoe, and orthopedic problems. In the Czech Republic, childhood obesity is now a serious epidemiological problem: 20% of children aged 6-12 and 11% of children aged 13-17 years are already overweight or obese. These data were provided by the study of the Czech Obesity Association entitled "Life Style and INTRODUCTION

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“…In reality, index QUICKI which has narrower confidence intervals and hence less variability may be more useful 1,11 . Healthy children have values of QUICKI index around 0.29.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Obesity, Hypertension and Insulin Resistance in Childhood - A Pilot Study

Pastucha¹,

Talafa²,

Malinčíková³

et al. 2010

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Frozen second-hour serum samples were used to analyze the blood insulin levels. Insulin resistance was assessed by homeostasis model assessment (HOMA) index for each patient [19].…”

Section: Methodsmentioning

confidence: 99%

“…Numbers of pre/ postpubertal (Tanner stage 2 or more) patients were 11/12 in HOB group, 5/11 in HNOB group, and 13/9 in OB group (p=0. 19).…”

Section: Patient Characteristicsmentioning

confidence: 99%

The role of leptin, soluble leptin receptor, resistin, and insulin secretory dynamics in the pathogenesis of hypothalamic obesity in children

et al. 2008

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“…Obesity in children in the United States and other western countries is rising at an alarming rate, with nearly 1 in 5 children being obese in 2004 [66]. These children are at high risk for developing insulin resistance [67,68], which is perceived to be a trigger for oncogenic events [59]. The prevalent notion on how obesity confers cancer susceptibility points to energy overloading-induced insulin resistance (via negative feedback at the cellular level) in peripheral glucose-utilizing/storing tissues, such as skeletal muscle, adipose tissue or liver, as the trigger that predisposes to the development of T2D [69].…”

Section: Molecular Mechanism(s) Of Ship2 Overex-pression and Ship2 Fumentioning

confidence: 99%

Two Diseases with One Hit: Inhibiting a Potential Diabetes Target to Reduce Cancer Risk and to Improve Anti-Cancer Therapy

Prasad¹

2009

CCTR

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Obesity is a well-recognized cancer risk factor. The increase in risk for colorectal, endometrial, breast and esophageal cancers associated with obesity ranges from 1.5-to as much as 3-fold. Obese patients develop more aggressive cancers that are less responsive to treatment. Here, we review the available data on an obesity-linked gene, SH2-domaincontaining inositol 5-phosphatase-2 (SHIP2), in light of new experimental and clinical evidence of its pro-oncogenic role. A putative diabetes drug target, SHIP2 is an important negative regulator of insulin signaling that acts downstream of phosphoinositide 3-kinase (PI3-kinase). In mice, SHIP2 levels are increased by a high-fat diet, and its knockout prevents diet-induced obesity. Taking together these findings, we propose that SHIP2 is a potential anti-cancer target with a high therapeutic index owing to its cancer-specific overexpression and/or differential function combined with the absence of major untoward effects upon its loss of function in normal cells. We compare and contrast the pro-oncogenic function of SHIP2 with the current understanding of cancer-relevant functions of PTEN and PTP-1B, two negative regulators of insulin function. The provocative idea that a negative regulator of insulin function will positively influence oncogenesis presents the intriguing possibility that its inhibition will be a beneficial strategy for two major therapeutic areas: metabolic diseases (such as obesity and diabetes) and cancer.

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Obesity and Insulin Resistance in Childhood

Cited by 12 publications

References 7 publications

Obesity, Hypertension and Insulin Resistance in Childhood - A Pilot Study

Obesity, Hypertension and Insulin Resistance in Childhood - A Pilot Study

The role of leptin, soluble leptin receptor, resistin, and insulin secretory dynamics in the pathogenesis of hypothalamic obesity in children

Two Diseases with One Hit: Inhibiting a Potential Diabetes Target to Reduce Cancer Risk and to Improve Anti-Cancer Therapy

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