Obesity-and lipid-related indices as a risk factor of hypertension in mid-aged and elderly Chinese: a cross-sectional study

Abstract

Objective Hypertension refers to the persistent elevation of blood pressure above the established normal range, resulting in increased pressure exerted by blood on the walls of blood vessels during its circulation. Recent studies have identified significant associations between obesity and lipid-related indices, as well as hypertension. Nevertheless, these studies have yet to comprehensively examine the correlation between the two variables. Our objective is to identify the fat and lipid-related indices that have the strongest correlation with hypertension. Method There was a total of 9488 elderly and middle-aged Chinese citizens who participated in this investigation. The participants in this research were separated into distinct gender cohorts. The participants were classified into normal and hypertensive categories according to their gender, with hypertension defined as a blood pressure level of 140/90 mmHg or higher, or a history of hypertension. Through the utilization of binary logistic regression analyses and the receiver operator curve (ROC), the optimal among fourteen indicators associated with obesity and lipids were identified. Results After adjusting for variables, statistical analysis showed that all 14 measures of obesity and lipid were risk factors for hypertension. The receiver operating characteristic (ROC) curve analysis reveals that the Chinese visceral adiposity index (CVAI) has the highest degree of relationship to hypertension. Simultaneously, a statistically significant association between hypertension and these 14 variables was observed in both males and females. Conclusion There was a significant independent association between various parameters related to obesity and lipid-related index and the presence of hypertension, indicating that these factors can be considered risk factors for hypertension. CVAI and WHtR (waist height ratio) can be used to screen the high-risk groups of hypertensions in middle-aged and elderly people in China, and then take individualized health care measures to reduce the harm of hypertension.

The effect of insulin resistance in the association between obesity and hypertension incidence among Chinese middle-aged and older adults: data from China health and retirement longitudinal study (CHARLS)

“…Recent studies have shown that visceral adipose tissue (VAT) is more strongly associated with the development of hypertension than subcutaneous abdominal adipose tissue ( 23 , 24 ), The CVAI index has emerged as a straightforward and reliable indicator of visceral adiposity in Chinese individuals and is gaining attention due to its association with hypertension. In comparison with waist-to-hip ratio, BMI, and lipid accumulation product (LAP), the CVAI has demonstrated greater accuracy in assessing visceral adiposity in Chinese populations ( 13 , 25 , 26 ). A cross-sectional study involving 9,488 Chinese participants, which compared the predictive value of CVAI with other obesity indices including BMI, WC, VAI, LAP, waist-to-height ratio, body shape index, and body roundness index, revealed that the CVAI was the most reliable predictor of hypertension incidence ( 25 ).…”

“…In comparison with waist-to-hip ratio, BMI, and lipid accumulation product (LAP), the CVAI has demonstrated greater accuracy in assessing visceral adiposity in Chinese populations ( 13 , 25 , 26 ). A cross-sectional study involving 9,488 Chinese participants, which compared the predictive value of CVAI with other obesity indices including BMI, WC, VAI, LAP, waist-to-height ratio, body shape index, and body roundness index, revealed that the CVAI was the most reliable predictor of hypertension incidence ( 25 ). Additionally, Han and colleagues found that the CVAI exhibited superior predictive performance for hypertension among 9,359 rural residents in the Henan Province of China ( 27 ).…”

Prevalence and factors associated with dyslipidemia in patients with first hospitalization for major depressive disorder: a large sample cross-sectional study

“…Therefore, we collected thyroid function indices (especially TSH, free triiodothyronine (FT 3 ), and free tetraiodothyronine (FT 4 ) levels) from our patients. Considering the influence of other metabolic indicators on lipids, we also collected other clinical indicators such as body mass index (BMI) [ 24 ], waist circumference (WC) [ 25 ], and blood pressure level [ 26 ] (specifically, systolic blood pressure, SBP; diastolic blood pressure, DBP).…”

Obesity and consequent changes in the body

“…Povećana proizvodnja reaktivnih kiseoničkih radikala u mitohondrijama nastaje u uslovima povećane koncentracije glukoze i masnih kiselina u adipocitima, čija povećana količina dovodi do izmena u redoks potencijalu sekretornih puteva i utiče na koncentraciju i sekreciju pojedinih adipokina. Samo oslobađanje reaktivnih radikala iz masnog tkiva u krvotok remeti sekreciju insulina u pankreasu i učestvuje u patogenezi ateroskleroze i hipertenzije (48). Pokazano je da je stanje gojaznosti povezano sa nastankom niske hronične sistemske inflamacije u masnom tkivu (32,49).…”