Obesity and muscle may have synergic effect more than independent effects on brain volume in community-based elderly

Lee, Hyeonbin; Seo, Hyung Suk; Kim, Regina E. Y.; Lee, Seung Ku; Lee, Young Hen; Shin, Chol

doi:10.1007/s00330-020-07407-2

Cited by 14 publications

(19 citation statements)

References 44 publications

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“…The area of vWAT had a significant negative association with temporal lobe volume, and the volume ratio of the thigh muscle to vWAT was found to be markedly positively correlated with temporal lobe, gray matter of the temporal lobe, and cerebellum. 25 Specifically, the thigh muscle/vWAT ratio was significantly positively correlated with right temporal pole, right inferior temporal cortex and left entorhinal cortex, all of which were thought to be related to cognition, and was markedly positively associated with right pallidum and bilateral cerebellar cortices, all of which were considered to be related to motor function. 25 But, the vWAT volume had a negative correlation with the temporal lobe volume.…”

Section: Evidence From Human Studies On the Association Between Brain...mentioning

confidence: 91%

“…The cortical thickness of global, parietal, temporal, cingulate and insula lobe Negatively Cross-sectional study 24 Community-dwelling healthy older population 1209 The volume ratio of the thigh muscle to vWAT vs. The volume of temporal lobe and cerebellum Positively Prospective study 25 The thigh muscle/vWAT volume ratio vs. The volume of left entorhinal cortex, right temporal pole and inferior temporal gyrus Positively The thigh muscle/vWAT volume ratio vs.…”

Section: Evidence From Human Studies On the Association Between Brain...mentioning

confidence: 99%

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Bidirectional communication between brain and visceral white adipose tissue: Its potential impact on Alzheimer's disease

Huang¹,

Wang²,

Xiang³

2022

eBioMedicine

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Section: Evidence From Human Studies On the Association Between Brain...mentioning

confidence: 91%

Section: Evidence From Human Studies On the Association Between Brain...mentioning

confidence: 99%

Bidirectional communication between brain and visceral white adipose tissue: Its potential impact on Alzheimer's disease

Huang¹,

Wang²,

Xiang³

2022

eBioMedicine

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“…However, after adjusting for related factors, this was not significant. These results suggest that sex, age [43], metabolic syndrome factors [43], and muscle mass [44] may have influenced the association. In fact, cerebral atrophy is reported in diabetes patients [45].…”

Section: Discussionmentioning

confidence: 85%

Association between Visceral Fat and Brain Structural Changes or Cognitive Function

et al. 2021

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Visceral fat accumulation is an independent risk factor for cardiovascular disease and mortality. Visceral fat is a causal risk factor for hypertension and type 2 diabetes, which was reported as one of the risk factors for dementia. Visceral fat areas (VFA) might be clinically important to prevent dementia; however, the association between VFA and cognitive function in the elderly remains unknown. We aimed to evaluate the association between brain structural abnormalities using magnetic resonance imaging (MRI) and VFA, and the association between cognitive function and VFA, in the elderly. A total of 2364 healthy individuals were enrolled, and we excluded those diagnosed with dementia. Participants were divided into a high-VFA and a low-VFA group based on median VFA. The high-VFA group had significantly lower cognitive function than the low-VFA group (p = 0.025), after adjustment for related factors using a linear regression model. Regarding brain structure in MRI, VFA remained significantly associated with white matter lesions (odds ratio (OR), 1.90; 95% confidence interval (1.33–2.70); adjusted p < 0.001) and perivascular space (OR, 1.28; 95% confidence interval (1.02–1.61); adjusted p = 0.033). Further follow-up studies are needed, but reducing visceral fat might be important, not only to prevent cardiovascular disease but also to prevent dementia.

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“…A recent study observed that the ratio of thigh muscle to visceral fat was positively correlated with the volumes of entorhinal cortex, temporal pole, and inferior temporal gyrus related to cognition. Additionally, the ratio of thigh muscle to visceral fat was positively correlated with the volumes of cerebellum and pallidum related to movement 44 …”

Section: Discussionmentioning

confidence: 95%

Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID‐19

Brasil

Renck

Taccone

et al. 2021

Obesity Science & Practice

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Objective Multiple factors have been identified as causes of intracranial compliance impairment (ICCI) among patients with obesity. On the other hand, obesity has been linked with worst outcomes in COVID‐19. Thus, the hypothesis of severe acute respiratory syndrome (SARS) conducing to cerebral hemodynamic disorders (CHD) able to worsen ICCI and play an additional role on prognosis determination for COVID‐19 among obese patients becomes suitable. Methods 50 cases of SARS by COVID‐19 were evaluated, for the presence of ICCI and cerebrovascular circulatory disturbances in correspondence with whether unfavorable outcomes (death or impossibility for mechanical ventilation weaning [MVW]) within 7 days after evaluation. The objective was to observe whether obese patients (BMI ≥ 30) disclosed worse outcomes and tests results compared with lean subjects with same clinical background. Results 23 (46%) patients among 50 had obesity. ICCI was verified in 18 (78%) obese, whereas in 13 (48%) of 27 non‐obese ( p = 0,029). CHD were not significantly different between groups, despite being high prevalent in both. 69% unfavorable outcomes were observed among obese and 44% for lean subjects ( p = 0,075). Conclusion In the present study, intracranial compliance impairment was significantly more observed among obese subjects and may have contributed for SARS COVID‐19 worsen prognosis.

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Obesity and muscle may have synergic effect more than independent effects on brain volume in community-based elderly

Cited by 14 publications

References 44 publications

Bidirectional communication between brain and visceral white adipose tissue: Its potential impact on Alzheimer's disease

Bidirectional communication between brain and visceral white adipose tissue: Its potential impact on Alzheimer's disease

Association between Visceral Fat and Brain Structural Changes or Cognitive Function

Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID‐19

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