Obesity and Osteoarthritis: More Than Just Wear and Tear

Koonce, Ryan C.; Bravman, Jonathan T.

doi:10.5435/jaaos-21-03-161

Cited by 48 publications

(45 citation statements)

References 42 publications

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“…In addition, female patients had a higher prevalence of multijoint OA than males, and several related factors were more closely associated in female patients. It appears that women are more susceptible to multijoint OA than men for several reasons, [36–38] including hormonal changes and osteoporosis, which may accelerate degenerative changes in multiple joints.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of symptomatic hip, knee, and spine osteoarthritis nationwide health survey analysis of an elderly Korean population

et al. 2017

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Osteoarthritis is prominent among the elderly, with symptoms originating from multiple parts of the body. A cross-sectional study of a nationwide survey was performed to describe the prevalence of and identify factors related to symptomatic hip, knee, and spine osteoarthritis.This cross-sectional study collected data from the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V-5; 2010–2012). After excluding ineligible subjects, there were 8976 subjects in this study (3830 males and 5146 females). All subjects reported symptoms and disabilities related to osteoarthritis. Plain radiographs of the spine, hip, and knee were taken in all subjects.Overall, 9.3% of male participants and 28.5% of female participants were diagnosed with symptomatic osteoarthritis according to survey criteria. Women showed a significantly higher prevalence in all age groups (P < 0.05). Multiple-joint osteoarthritis was diagnosed in 10.8% of male patients and 22.8% of female patients with osteoarthritis. Several demographic and lifestyle variables were related to osteoarthritis morbidity. Anthropometric and laboratory measurements were also related to osteoarthritis morbidity. In addition, mental distress and quality of life were significantly compromised in osteoarthritis. There were more significant relationships for these factors among women with a higher prevalence of multijoint osteoarthritis.A significant proportion of the elderly with single- or multiple-joint osteoarthritis had a variety of pain origins that were closely related. Osteoarthritis was also significantly related to several factors, including mental distress and quality of life.

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Section: Discussionmentioning

confidence: 99%

Prevalence of symptomatic hip, knee, and spine osteoarthritis nationwide health survey analysis of an elderly Korean population

et al. 2017

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“…40 Recent data also indicate that in addition to the mechanical risks of obesity on arthritis there is a link between lipid metabolism and an enhanced inflammatory state with ''direct pathologic effects on the musculoskeletal system'' and a link to the development of osteoarthritis. 41 White fat found in obese people is an energy depot but is also a source of proinflammatory immunomodulatory cytokines (adipocytokines) found in plasma and synovial fluid. These adipose tissue cytokines are thought to be a causative factor of osteoarthritis.…”

Section: Health Risk Of Obesity In Athletesmentioning

confidence: 99%

The prevalence and consequences of obesity in athletes

Griffin

Maxwell

Griffin

2016

Current Orthopaedic Practice

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Athletes are getting bigger and stronger, but in some sports they are getting bigger not only by adding muscle mass, but also fat. During their careers, athletes should seek nutritional counseling to assure that most of their weight gain is muscle not fat. Counseling also should be provided to athletes at the end of their competitive careers to help them effectively change their eating habits and maintain a reasonable exercise program to transition into a healthy weight for life. This will reduce the risks of developing metabolic syndrome, cardiovascular disease, sleep disordered breathing issues, osteoarthritis, and other medical issues that are associated with obesity in athletes and in the general population.

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“…One of the well-known risk factors for OA is obesity [20, 21]. C57BL/6J male mice fed a high-fat diet (HFD) for 12 weeks have greater body weight and also exhibit features consistent with knee OA, compared to the control mice [22].…”

Section: Obesity and Oamentioning

confidence: 99%

Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role

Luo

Deng

et al. 2016

Mediators of Inflammation

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Intestinal microbiota is highly involved in host physiology and pathology through activity of the microbiome and its metabolic products. Osteoarthritis (OA) is a common form of arthritis characterized by articular cartilage destruction and osteophyte formation. Although various person-level risk factors, such as age, sex, and obesity, have been proposed for the pathogenesis of OA, the underlying links between these person-level factors and OA are still enigmatic. Based on the current understanding in the crosstalk between intestinal microbiota and these risk factors, intestinal microbiota could be considered as a major hidden risk factor that provides a unifying mechanism to explain the involvement of these person-level risk factors in OA.

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Obesity and Osteoarthritis: More Than Just Wear and Tear

Cited by 48 publications

References 42 publications

Prevalence of symptomatic hip, knee, and spine osteoarthritis nationwide health survey analysis of an elderly Korean population

Prevalence of symptomatic hip, knee, and spine osteoarthritis nationwide health survey analysis of an elderly Korean population

The prevalence and consequences of obesity in athletes

Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role

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