Obesity and oxidative stress in patients with different periodontal status: a case–control study

Atabay, Vadim Ekrem; Lütfioğlu, Müge; Avcı, Bahattin; Sakallıoğlu, Elif Eser; Aydoğdu, Ahmet

doi:10.1111/jre.12368

Cited by 52 publications

(54 citation statements)

References 50 publications

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“…Oxidative stress in HFD-fed rats was presented as higher plasma ROS and lower plasma antioxidant levels in accordance with previous studies [13,14]. In the present study, the results indicated that OP and OR rats showed different degrees of oxidative damage.…”

Section: Discussionsupporting

confidence: 92%

Sodium butyrate protects against oxidative stress between obesity-prone and obesity-resistant rats induced by HFD through modulating Nrf2 pathway and mitochondrial function

Lu¹,

Sun²,

Li³

et al. 2020

Preprint

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Background Sodium butyrate (NaB) is obtained by fermenting dietary fiber via intestinal microflora and has recently been shown to improve some antioxidant enzymes in vivo. Methods In this study, we investigated the antioxidant effects of Sodium butyrate on obesity rats induced by high-fed diet. Results NaB intervention could effectively reduce the body weight of rats in the obesity-prone(OP) and obesity-resistant(OR)group, and reduce insulin resistance, plasma lipid, protect the gastrocnemius muscle and pancreas from oxidative stress induced by high fat diet, upregulate T-AOC, antioxidant enzyme activity and GSH/GSSG ratio, reduce ROS level and MDA content. NaB may increase Pi3k, Nrf2, Nqo-1, Ho-1 and inhibit Gsk-3β mRNA expression by regulating Nrf2 antioxidant pathway to enhance tissue antioxidant capacity. At the same time, NaB intervention could significantly increase the expression of Glut4 and Irs-1 mRNA in gastrocnemius muscle of OP and OR rats, suppress the expression of Bax and Caspase 3, increase the mRNA expression of Pdx1, MafA and Bcl-2, and increase insulin secretion and muscle insulin sensitivity. The regulatory effect of NaB was correlated with its significantly increased activity of mitochondrial antioxidant enzymes, mitochondrial membrane potential, NADH/NAD+ ratio, acetyl-CoA and ATP production, Tfam and Pgc-1α expression and mitochondrial DNA copy number. In addition, 6% NaB intervention in OP rats, 4%NaB intervention in OR rats were more significant, indicating that there were dose effects of NaB intervention in different obesity phenotypes. Conclusions NaB activates the Nrf2 antioxidant pathway, enhances the expression level of downstream antioxidant genes, improves the antioxidant capacity of obese rat tissues, and at the same time promotes muscle protein synthesis, improves insulin sensitivity, and promotes glucose metabolism.

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Section: Discussionsupporting

confidence: 92%

Sodium butyrate protects against oxidative stress between obesity-prone and obesity-resistant rats induced by HFD through modulating Nrf2 pathway and mitochondrial function

Lu¹,

Sun²,

Li³

et al. 2020

Preprint

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show abstract

“…Present study showed significant positive correlations between MDA (serum and salivary) with weight and body mass index. Similar findings were observed by Atabay et al 18 indicating that increases in serum and salivary MDA levels associated with increased weight and BMI, regardless of periodontal status, are reflective of increases in oxidative stress as a result of obesity. Obesity may be described as a state in which systemic, low-grade inflammatory stimulus can produce oxidative stress 18 .…”

Section: Discussionsupporting

confidence: 87%

“…Similar findings were observed by Atabay et al 18 indicating that increases in serum and salivary MDA levels associated with increased weight and BMI, regardless of periodontal status, are reflective of increases in oxidative stress as a result of obesity. Obesity may be described as a state in which systemic, low-grade inflammatory stimulus can produce oxidative stress 18 . In contrast to our findings Blok et al 13 found that body mass index is not associated with MDA.…”

Section: Discussionsupporting

confidence: 87%

Saliva and Serum Malondialdehyde Levels in Apparently Healthy Individuals in Kurdistan Region / Iraq

Omer

Abdullah

Ali

2018

DMJ

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Background: Saliva is a fluid secreted by the salivary glands and it is divided in to serous and mucus components. Despite its physiological roles in lubricating the oral cavity and digestion, it also acts as a simple diagnostic tool reflecting body's systemic diseases. The aim of the present study is to determine malondialdehyde (MDA) levels in saliva and serum of apparently healthy individuals and to find if there is an association between dental caries, periodontal disease and salivary MDA. Subject and Methods: This cross sectional study involved sixty fourparticipants who were medical students attending Duhok College of Medicine. Clinical information and all relevant data were obtained according to a questionnaire. Both salivary and serum MDA levels were measured manually in unstimulated saliva and sera of participants using Thiobarbuturic acid method. Results: Malondialdehyde is measurable in saliva of apparently healthy individuals and was significantly lower than serum MDA level (p<0.001). There was a statistically highly significant positive correlation between both salivary and serum MDA levels (p=0.0007). Moreover, both Salivary and serum MDA levels were significantly positively correlated with weight and BMI (p=0.03, p=0.03 and p= 0.04 and 0.05) respectively. There were no significant correlations between salivary MDA with dental caries index (dmft score) and periodontal disease index. Conclusions: Based on the current results, salivary MDA is significantly positively correlated with serum MDA, weight and BMI. No significant association of salivary MDA with dental caries and periodontal disease were observed.

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“…When polyunsaturated lipids undergo a series of non-enzymatic reactions that produce a wide range of intermediate and end products due to ROS, MDA was the most specific molecule and the one most often used for the measurement of biological lipid oxidation [20]. MDA in serum, saliva, or gingival crevicular fluid is a marker of oxidative stress in human chronic periodontitis [21,22,23]. In experimental periodontitis, an increased MDA level was observed in the periodontal tissue [24].…”

Section: Discussionmentioning

confidence: 99%

Visualization of Oxidative Stress Induced by Experimental Periodontitis in Keap1-Dependent Oxidative Stress Detector-Luciferase Mice

Kataoka

Ekuni

Tomofuji

et al. 2016

IJMS

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The aim of this study was to investigate whether a Keap1-dependent oxidative stress detector-luciferase (OKD-LUC) mouse model would be useful for the visualization of oxidative stress induced by experimental periodontitis. A ligature was placed around the mandibular first molars for seven days to induce periodontitis. Luciferase activity was measured with an intraperitoneal injection of d-luciferin on days 0, 1, and 7. The luciferase activity in the periodontitis group was significantly greater than that in the control group at seven days. The expressions of heme oxygenase-1 (HO-1) and malondialdehyde in periodontal tissue were significantly higher in the periodontitis group than in the control group. Immunofluorescent analysis confirmed that the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) occurred more frequently in the periodontitis group than in the control group. This study found that under oxidative stress induced by experimental periodontitis, the Nrf2/antioxidant defense pathway was activated and could be visualized from the luciferase activity in the OKD-LUC model. Thus, the OKD-LUC mouse model may be useful for exploring the mechanism underlying the relationship between the Nrf2/antioxidant defense pathway and periodontitis by enabling the visualization of oxidative stress over time.

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Obesity and oxidative stress in patients with different periodontal status: a case–control study

Abstract: Obesity may influence periodontal tissue destruction and disease severity by increasing the level of oxidative stress in the presence of periodontal disease.

Cited by 52 publications

References 50 publications

Sodium butyrate protects against oxidative stress between obesity-prone and obesity-resistant rats induced by HFD through modulating Nrf2 pathway and mitochondrial function

Sodium butyrate protects against oxidative stress between obesity-prone and obesity-resistant rats induced by HFD through modulating Nrf2 pathway and mitochondrial function

Saliva and Serum Malondialdehyde Levels in Apparently Healthy Individuals in Kurdistan Region / Iraq

Visualization of Oxidative Stress Induced by Experimental Periodontitis in Keap1-Dependent Oxidative Stress Detector-Luciferase Mice

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