Obesity and poor reproductive outcome: the potential role of the endometrium

Bellver, José; Melo, Marco; Bosch, Ernesto; Serra, Vicente; Remohı́, José; Pellicer, António

doi:10.1016/j.fertnstert.2006.11.162

Cited by 264 publications

(190 citation statements)

References 35 publications

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…Thus, our findings that obesity was associated with lower implantation rates and higher spontaneous abortion rates are similar to those described in the literature [17][18][19][20][21]. It has been suggested that the adverse effects of obesity on IVF outcomes may be attributed to the alteration in the uterine environment [22,23]. Furthermore, increased levels of inflammatory markers such as interleukin-6 and tumor necrosis factor-α found in obese women may negatively impact implantation and early embryonic development [24][25][26].…”

Section: Discussionsupporting

confidence: 88%

Optimal parameters for determining the LH surge in natural cyclefrozen-thawed embryo transfers

Irani

Robles

Gunnala

et al. 2016

Fertility and Sterility

View full text Add to dashboard Cite

Background: There is no consensus on the exact parameters that define the LH surge for natural cycle frozenthawed embryo transfers (NC-FET). Accurately determining the LH surge would affect the timing, and subsequently the success rates, of embryo transfer. Therefore, the aim of this study was to delineate the optimal levels and relationship for luteinizing hormone (LH) and estradiol in an effort to optimally identify the LH surge in NC-FET.

show abstract

Section: Discussionsupporting

confidence: 88%

Optimal parameters for determining the LH surge in natural cyclefrozen-thawed embryo transfers

Irani

Robles

Gunnala

et al. 2016

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…Maternal obesity has been shown to increase the risk of stillbirth; the higher the body mass index the greater the chance of SB. In a metaanalysis conducted by Metwally et al [29], women with BMI ≥ 30 were at increased risk of miscarriage (SB) compared to women with normal BMI [OR = 1.89; 95% CI: 1.14 -3.13]. It is postulated that an unfavorable hormonal characteristic of maternal obesity as well as chronic inflammation from excess adipose tissue might be the underlying mechanism of action [30].…”

Section: Discussionmentioning

confidence: 99%

Stillbirth in Nigeria: Rates and Risk Factors Based on 2013 Nigeria DHS

Dahiru¹,

Aliyu²

2016

OALib

View full text Add to dashboard Cite

Introduction: Stillbirth remains a public health problem with an estimate of 2.6 million stillbirths in 2015 of which 98% occurred in low-and middle-income countries and over three-quarters of these occurring in Sub-Saharan Africa (SSA) and south Asia. Further, only ten countries carry the burden of over 65% of total stillbirths in the world including Nigeria in the second position. The objective of this analysis is to estimate stillbirth rates and identify the determinants of stillbirth in Nigeria using the 2013 Nigeria DHS data. Methods: The study utilized the nationally-representative sample of women of reproductive age interviewed during the 2013 Nigeria DHS. Analysis was restricted to 31,671 women aged 15 -49 years who had a pregnancy reaching at least seven months of gestation in the five-year period prior to the survey. Descriptive statistics and regression analysis were performed using Stata v13 to determine significant factors related to stillbirth. Incidence Risk Ratio (IRR) was used to assess strength of association between independent and dependent variables. Results: Overall stillbirth rate is 12.5 per 1000 pregnancies, with rates as high as 22 per 1000 (among women aged 15 -19 years) and as low as 6.4 per 1000 (among women who received skilled ANC). Age, household wealth, higher birth order, facility delivery, Caesarean delivery, rural residence and ever use of contraceptive are consistent determinants of stillbirth in both the bivariate and multivariate models. Women in rich households have lower IRR of stillbirth (0.60; 95% CI: 0.45 -0.59) as well as women who had ever used modern contraception (IRR = 0.72; 95% CI: 0.63 -0.81). However, health facility deliveries as well as deliveries through a C-section, rural residence and age older than 20 years all carry increased risk of stillbirth (IRR = 1.81; 95% CI: 1.05 -1.33), (IRR = 2.46; 95% CI: 2.03 -2.98), (IRR = 1.41; 95% CI: 1.24 -1.59), and (IRR = 2.23; 95% CI: 1.75 -2.59) respectively. Conclusions: The study revealed that there are several factors responsible for stillbirth in Nigeria. Age, household wealth, higher birth order, facility delivery, Caesarean delivery, rural residence and ever use of contraceptive are consistent determinants of stillbirth in both the bivariate and multivariate models. There is urgent need by the National government to improve quality of maternal health care services and interventions to improve utilization and quality of prenatal care.

show abstract

“…Meta-analysis by Griesinger et al showed similar benefits of GnRH analogs regarding PCOS populace [11]. On the other hand, meta-analyses mentioned above did not consider high body mass index (BMI) as an exclusion criteria, while current studies report obesity to be associated with relative gonadotropin resistance [12], lower number of collected oocytes [13,14] as well as general poorer IVF outcome [15]. According to the latest consensus on infertility treatment related to PCOS, the optimal stimulation protocol is still under debate [4].…”

Section: Introductionmentioning

confidence: 89%

Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study

Kurzawa

Ciepiela

Bączkowski

et al. 2008

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose Embryological and clinical efficacy of gonadotropinreleasing hormone (GnRH) antagonist and agonist stimulation protocols in non-obese women with polycystic ovarian syndrome (PCOS) were compared. Methods A prospective randomized study. Setting: Medical University Hospital. Patients: 70 infertile PCOS patients; 33 in GnRH antagonist and 37 in GnRH agonist group. Results Similar mature metaphase II oocyte rate (76% vs. 76%) was observed in both protocols. Optimal pronuclear morphology zygotes dominated in both groups (64% vs. 66%). Transferred embryo quality did not differ in both protocols. No significant differences between both protocols were found in delivery rate ( p=0.481), pregnancy rate ( p=0.810), multiple pregnancy rate ( p=0.501), miscarriage rate ( p=0.154), fertilization rate ( p=0.388) and implantation rate (p=1.000). Duration of stimulation and total follicle-stimulating hormone (FSH) dose were significantly lower in GnRH antagonist protocol ( p=0.0005). Conclusions GnRH antagonist and agonist protocols in non-obese PCOS patients yield similar embryological and clinical outcomes. Shorter duration of treatment and lower FSH requirement in GnRH antagonist group may be financially beneficial and therefore attractive for patients.

show abstract

Obesity and poor reproductive outcome: the potential role of the endometrium

Cited by 264 publications

References 35 publications

Optimal parameters for determining the LH surge in natural cyclefrozen-thawed embryo transfers

Optimal parameters for determining the LH surge in natural cyclefrozen-thawed embryo transfers

Stillbirth in Nigeria: Rates and Risk Factors Based on 2013 Nigeria DHS

Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study

Contact Info

Product

Resources

About