Obesity and Pulmonary Embolism: Can We Dismantle the “Obesity Paradox”

Goldhaber, Samuel Z.

doi:10.1055/a-2187-0966

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Non-PE-based studies have highlighted that cardiopulmonary fitness is an often-overlooked potential modifier of obesity paradox, and levels of fitness can significantly alter the inverse association between obesity and mortality [21]. The alternative explanation may be that BMI is not be the ideal definition of obesity [22]. In a study from the UK Biobank, waist-hip ratio was found to have the strongest association with all-cause mortality when compared with BMI and fat mass index [23].…”

Section: Discussionmentioning

confidence: 99%

The Obesity Mortality Paradox in Patients with Pulmonary Embolism: Insights from a Tertiary Care Center

Alkhalfan,

Bukhari,

Rosenzveig

et al. 2024

JCM

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Background: While obesity is associated with an increased risk of venous thromboembolism (VTE), there is some data to suggest that higher BMI is also associated with decreased all-cause mortality in patients with a pulmonary embolism (PE). Methods: Using PE Response Team (PERT) activation data from a large tertiary hospital between 27 October 2020 and 28 August 2023, we constructed a multivariate Cox proportional hazards model to assess the association between obesity as a dichotomous variable (defined as BMI ≥ 30 vs. BMI 18.5–29.9), BMI as a continuous variable, and 30-day PE-related mortality. Results: A total of 248 patients were included in this analysis (150 with obesity and 98 who were in the normal/overweight category). Obesity was associated with a lower risk of 30-day PE-related mortality (adjusted HR 0.29, p = 0.036, 95% CI 0.09–0.92). A higher BMI was paradoxically associated with a lower risk of PE-related mortality (HR = 0.91 per 1 kg/m2 increase, p = 0.049, 95% CI 0.83–0.999). Conclusions: In our contemporary cohort of patients with a PERT activation, obesity was associated with a lower risk of PE-related mortality.

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Section: Discussionmentioning

confidence: 99%

The Obesity Mortality Paradox in Patients with Pulmonary Embolism: Insights from a Tertiary Care Center

Alkhalfan,

Bukhari,

Rosenzveig

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…Importantly, the study from Gaugler et al 47 reassuringly confirmed that body mass index did not impact the effectiveness of ageadjusted D-dimer in patients suspected of having PE. While weight management may prove beneficial in reducing the burden of VTE, 48 preventing obesity in the first place should become a priority. 49 Certain type of dieting that venous thrombosis patients may be attempting are also associated with potential risks, as illustrated by the particularly intriguing case report, of an individual who developed DVT complication while on a zero-calorie diet regimen.…”

Section: Weightmentioning

confidence: 99%

Thrombosis and Haemostasis 2023 Editors' Choice Papers

Weber,

Rigby,

Lip

2024

Thromb Haemost

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Obesity and Pulmonary Embolism: Can We Dismantle the “Obesity Paradox”

Abstract: No Abstract

Cited by 2 publications

References 16 publications

The Obesity Mortality Paradox in Patients with Pulmonary Embolism: Insights from a Tertiary Care Center

The Obesity Mortality Paradox in Patients with Pulmonary Embolism: Insights from a Tertiary Care Center

Thrombosis and Haemostasis 2023 Editors' Choice Papers

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