Obesity and Reproduction

Oliveira, J.B.A.

doi:10.5935/1518-0557.20160037

Cited by 6 publications

(4 citation statements)

References 10 publications

(20 reference statements)

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“…The global increase of obesity in the population at reproductive age calls for reviews concerning its influence on natural and assisted reproduction ( ASRM, 2015 ; Oliveira, 2016 ). There are few studies that analyzed the effects of obesity in patients who underwent assisted reproduction treatments, and their results are controversial ( Koatz & de Souza, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

The adverse effect of overweight in assisted reproduction treatment outcomes

Sampo¹,

Palena²,

Ganzer³

et al. 2017

JBRA Assisted Reproduction

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ObjectiveTo assess Body Mass Index (BMI) effects on the results obtained from ICSI cycles.MethodsWe studied 266 ICSI cycles performed between January 2014 and December 2016. The patients were grouped according to their BMI in: Normal (18.5-24.9), Overweight (25.0-29.9) and Obese (>30). We compared the following variables between the groups: number of antral follicles, ovarian stimulation length, gonadotropin dose used, maximum estradiol level, follicles developed/antral follicles, retrieved oocytes/developed follicles and mature/retrieved oocytes, normal fertilization rate, embryo achieved/normal fertilized oocytes, clinical pregnancy and implantation rates. We used the Kruskal-Wallis and the Chi square tests. p<0.05 was considered significant.ResultsNormal, Overweight and Obese patients presented comparable values for number of antral follicles (11.6±5.4, 12.5±5.5, 12.2±5.7), ovarian stimulation length (7.5±1.4, 7.6±1.1, 7.8±1.3) and gonadotropin dose used (2043±489, 1940±536, 2109±605). Obese patients had lower values of estradiol (1560±610, 1511±635, 1190±466; p=0.018), developed follicles (81%, 76%, 70%; p<0.0001), and retrieved oocytes (91%, 90%, 84%; p=0.0017); and not significantly lower values of mature oocytes (82%, 82%, 77%; p=0.26). The groups had comparable fertilization rates (72%, 73%, 69%) and embryo achieved rates (67%, 63%, 72%). The normal group had higher, but not significantly higher pregnancy and implantation rates (43%, 40%, 38%, p=0.53; and 33%, 26%, 23%; p=0.11), and significantly higher ongoing pregnancy rates (37%, 33%, 33%, p=0.042).ConclusionIncreased BMI patients had impaired ovarian response and lower pregnancy rates in ICSI cycles.

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Section: Introductionmentioning

confidence: 99%

The adverse effect of overweight in assisted reproduction treatment outcomes

Sampo¹,

Palena²,

Ganzer³

et al. 2017

JBRA Assisted Reproduction

View full text Add to dashboard Cite

show abstract

“…The imbalance between excessive food consumption and low practice of physical activity is the fundamental cause of excessive weight, which induces the production of several hormones that can affect fertility and cause negative obstetric and perinatal outcomes.Among these outcomes, some risks are increased: miscarriage, gestational diabetes, pre-eclampsia, preterm delivery, longer duration of labor work, fetal macrosomia, anomalous presentations, and increased instrumented or cesareandelivery. Furthermore, maternal overweight during pregnancy, based on intrauterine metabolic programming and in the postnatal period, increases the risk of obesity in children and the emergence of other diseases such as diabetes and cardiovascular diseases in the future 6 .…”

Section: Developmentmentioning

confidence: 99%

“…A diet aiming to better control insulin secretion and maintain healthy body mass, with adequate intake of proteins and antioxidants, can reduce toxins, resulting in the protection of egg maturation and preservation of ovarian health and physiology 2 . Additionally, the practice of regular physical activities must be combined with dietary changes 6 .…”

Section: Introductionmentioning

confidence: 99%

The relationship between overweight and female infertility

Costa¹,

Andrade²,

Soares³

et al. 2021

Rev Cienc Saude

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Excessive weight seems to negatively influence fertility, and as it is a modifiable factor, understanding this relationship can contribute to infertility treatment. Adipose tissue is responsible for releasing several hormones and cytokines related to the reproductive system, such as leptin, TNF-a, and Interleukin-6, substances that can negatively impact female fertility. Additionally, a woman's diet and lifestyle can influence body weight and fertility. Food consumption, characterized by a high intake of foods with high energy density, high levels of sugar, saturated fat, and poor nutrients, as well as physical inactivity, can favor excessive weight. Thus, losing body weight obtained through a healthy diet associated with physical activity may restore fertility in overweight women.

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“…Obesity is considered as one of the most frequently observed risk factors for infertility in both males and females as well, as it interferes with the success of the treatment of fertility [1]. The prevalence of obesity parallels increased industrial development which, in the Arabian Gulf, is related to a significant growth in income from rich deposits of oil reserves and resulting rapid urbanization and improved living conditions [2].…”

Section: Introductionmentioning

confidence: 99%

The Success of Ovulation Induction with Letrozole and Gonadotropins in Obese and Nonobese Women: A Study from a Tertiary Center

Gowri

Al-Amri

Almamari

et al. 2022

International Journal of Reproductive Medicine

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Background. Letrozole, an aromatase inhibitor, is suggested as a first-line drug for ovulation induction in women with polycystic ovary syndrome (PCOS) especially in obese women. Letrozole has also been used in women with unexplained infertility with similar rates of success to clomiphene. However, literature on letrozole and gonadotropins in obese and nonobese women is sparse. Hence, this study was done to assess the success of ovulation induction (OI) with letrozole plus follicle stimulating hormone (FSH) in obese ( BMI ≥ 30 kg/m2) and nonobese women ( BMI < 30 kg/m2). Methods. A retrospective descriptive cohort study was conducted involving 135 women who underwent OI with letrozole plus follicle stimulating hormone therapy and either timed intercourse or intrauterine insemination. The data was collected from the hospital information system, including the age, body mass index, the type of infertility, number of induction cycles with letrozole, number of gonadotropin injections, and the pregnancy occurrence following treatment. SPSS was used to analyze the data. Results. There were 135 women who used FSH injections along with letrozole. Of this, 28.5% obese women got pregnant compared to 29.2% nonobese women, but this did not attain statistical significance ( P = 0.75 ). About 70% of obese women and 57% on nonobese women had polycystic ovarian syndrome. The median number of FSH injections was six, and the interquartile range was 3 to 11. Conclusion. Of the 135 women undergoing letrozole and FSH, there was almost an equal probability of pregnancy in the obese group ( BMI ≥ 30 kg/m2) and nonobese women.

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Obesity and Reproduction

Cited by 6 publications

References 10 publications

The adverse effect of overweight in assisted reproduction treatment outcomes

The adverse effect of overweight in assisted reproduction treatment outcomes

The relationship between overweight and female infertility

The Success of Ovulation Induction with Letrozole and Gonadotropins in Obese and Nonobese Women: A Study from a Tertiary Center

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