Obesity and Risk of Breast Cancer Mortality in Hispanic and Non-Hispanic White Women: The New Mexico Women's Health Study

Connor, Avonne E.; Baumgartner, Richard N.; Pinkston, Christina; Baumgartner, Kathy B.

doi:10.1089/jwh.2012.4191

Cited by 20 publications

(30 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have shown that obesity is associated with increased risk of breast cancer mortality. [32][33][34][35] However, only a few studies have assessed MetS and risk of breast cancer mortality in women. 16,17 Previous studies have shown that women with MetS had an increased risk of breast cancer compared to those who did not.…”

Section: Discussionmentioning

confidence: 99%

Associations of metabolic syndrome and C‐reactive protein with mortality from total cancer, obesity‐linked cancers and breast cancer among women in NHANES III

Gathirua-Mwangi

Song

Monahan

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

Although metabolic syndrome (MetS) is a prognostic factor for cancer occurrence, the association of MetS and cancer mortality remains unclear. The purpose of this study was to evaluate whether MetS, components of MetS and C-reactive protein (CRP) are associated with cancer mortality in women. A total of 400 cancer deaths, with 140 deaths from obesity-linked-cancers (OLCas), [breast (BCa), colorectal, pancreatic and endometrial], linked through the National Death Index, were identified from 10,104 eligible subjects aged ≥18 years. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HR) for cancer mortality. MetS was associated with increased deaths for total cancer [HR = 1.33, 95% confidence interval (CI) 1.04-1.70] and BCa [HR = 2.1, 95% CI, 1.09-4.11]. The risk of total cancer [HR = 1.7, 95% CI, 1.12-2.68], OLCas [HR = 2.1, 95% CI, 1.00-4.37] and BCa [HR = 3.8, 95% CI, 1.34-10.91] mortality was highest for women with all MetS components abnormal, compared to those without MetS. Linear associations of blood-pressure [HR = 2.5, 1.02-6.12, Quartile (Q) 4 vs Q1, p trend = 0.004] and blood-glucose [HR = 2.2, 1.04-4.60, Q4 vs. Q1, p trend = 0.04] with total-OLCas mortality were observed. A threefold increased risk of BCa mortality was observed for women with enlarged waist circumference, ≥100.9 cm, [HR = 3.5, 1.14-10.51, p trend = 0.008] and in those with increased blood glucose, ≥101 mg/dL, [HR = 3.2, 1.11-9.20, p trend = 0.03] compared to those in Q1. None of the components of MetS were associated with total-cancer mortality. CRP was not associated with cancer mortality. In conclusion, MetS is associated with total-cancer and breast-cancer mortality, with waist circumference, blood pressure and blood glucose as independent predictors of OLCas and BCa mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Associations of metabolic syndrome and C‐reactive protein with mortality from total cancer, obesity‐linked cancers and breast cancer among women in NHANES III

Gathirua-Mwangi

Song

Monahan

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Some studies indicated that obesity was an important prognosis factor related to an increased risk of mortality (20,21). In the Asia-Pacific region, being overweight and/or obese was significantly 1.63-fold related to the greater risk of mortality from BC.…”

Section: Discussionmentioning

confidence: 99%

The prognostic link between metabolic syndrome and the different breast cancer molecular subtypes: a case control study.

Chen¹,

Zhang²,

Chen³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Metabolic syndrome (MetS) is an important factor related to the poor prognosis of breast cancer (BC). Molecular heterogeneity in the tumor may affect the consequence of BC. The main purpose of this study was to assess the prognostic link between MetS and the different BC molecular subtypes. Methods A total of 960 patients with BC were recruited from January 2010 to June 2014. The relationship between MetS and disease prognosis was assessed by using univariate and multivariate analyses. Results At recruitment, MetS was diagnosed in 199 patients (20.7%). The mean follow-up period was 68.5 months (range, 2–103 months). MetS remained significantly associated with 64% increased risk of recurrence (Hazard Ratio (HR)=1.64; 95% confidence interval (CI) 1.19–2.27, P<0.01) and twofold increased risk of mortality (HR=2.02, 95% CI 1.29–3.16, P<0.01) according to multivariate analysis. By reviewing BC molecular subtypes, the significant associations remained in the subsets of Luminal A (HR=3.1, 95% CI 1.28–4.57, P=0.01), Luminal B (Her2-negative) (HR=3.3, 95% CI 1.31–8.33, P=0.01), and Her-2-positive (non-Luminal) (HR=2.2, 95% CI 1.10–4.39, P=0.03). Conclusions MetS was significantly related to unfavorable prognosis in operable BC, especially in the subgroup of Luminal A. More studies are needed to definitively determine which factors influence the association of MetS with Luminal A subtype.

show abstract

“…La mediana del IMC de nuestra muestra fue 29 kg/m , valor que coincide con la literatura en la cual (42) se registra que el sobrepeso y obesidad es frecuente en pacientes con cáncer de mama . Por eso, se debe replantear al inicio de la quimioterapia una valoración nutricional para disminuir el RCV y poder (43) impactar en la sobrevida . (44) La HTA es la ECV más común y aproximadamente el 28,5% de la población es hipertensa .…”

Section: Discussionunclassified

Cardiovascular risk factors in patients with breast cancer. Is there a correlation with international reference standards?

León

Cabral²,

Escalada³

et al. 2020

Rev. virtual Soc. Parag. Med. Int

View full text Add to dashboard Cite

Introducción: el cáncer y las enfermedades cardiovasculares son dos entidades patológicas separadas. Sin embargo, poseen varias similitudes y posibles interacciones, que incluyen varios factores de riesgo similares. Objetivo: determinar y correlacionar los factores de riesgo cardiovascular en pacientes con cáncer de mama. Metodología: estudio longitudinal, prospectivo. Población: pacientes con diagnóstico de cáncer de mama que consultan en el Hospital Nacional de Itauguá y en el Instituto Nacional del Cáncer, Paraguay, entre marzo y agosto 2017. Se recogieron las variables relacionadas con las características basales de las pacientes y factores de riesgo cardiovascular. Resultados: se incluyeron 170 pacientes, con edad media 50±13 años. Los factores de riesgo cardiovascular detectados fueron diabetes mellitus 14,7%, hipertensión arterial 51,8%, tabaquismo 3,5%, sedentarismo 38,3%, sobrepeso/obesidad 70%. La mediana de colesterol LDL fue 131,5 mg/dL. El 26,5% tenían con score de Framingham con riesgo elevado y moderado. En la correlación por método de Spearman entre score de riesgo de Framingham y presión arterial diastólica se obtuvo significancia estadística tanto con la presión arterial en brazo (r 0,244, p 0,001) como en miembro inferior (r 0,27, p 0,0001). En la correlación entre IMC y presión arterial diastólica se obtuvo r 0,15 (p 0,03). Conclusión: se halló correlación estadística entre valores elevados de presión arterial diastólica con obesidad/sobrepeso, así como con riesgo cardiovascular moderado a alto. Se debe considerar la hipertensión arterial diastólica como factor de riesgo cardiovascular en pacientes con cáncer de mama. Palabras claves: neoplasias de la mama, factores de riesgo, enfermedades cardiovasculares, hipertensión arterial, diabetes mellitus

show abstract

Obesity and Risk of Breast Cancer Mortality in Hispanic and Non-Hispanic White Women: The New Mexico Women's Health Study

Cited by 20 publications

References 47 publications

Associations of metabolic syndrome and C‐reactive protein with mortality from total cancer, obesity‐linked cancers and breast cancer among women in NHANES III

Associations of metabolic syndrome and C‐reactive protein with mortality from total cancer, obesity‐linked cancers and breast cancer among women in NHANES III

The prognostic link between metabolic syndrome and the different breast cancer molecular subtypes: a case control study.

Cardiovascular risk factors in patients with breast cancer. Is there a correlation with international reference standards?

Contact Info

Product

Resources

About