Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study

Maccioni, Livia; Weber, Susanne; Elgizouli, Magdeldin; Stoehlker, Anne-Sophie; Geist, Ilona; Peter, Hans‐Hartmut; Vach, Werner; Nieters, Alexandra

doi:10.1186/s12889-018-5172-8

Cited by 64 publications

(56 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Excess body weight has been linked to immunological imbalances that can manifest as increased susceptibility to infections including URTIs 52 ; such infections can impart a considerable socioeconomic burden 53 . Probiotics have been found to have a preventative effect on the incidence/severity of URTI 54 .…”

Section: Discussionmentioning

confidence: 99%

A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being

Michael

Jack

Masetti

et al. 2020

Sci Rep

View full text Add to dashboard Cite

in an exploratory, block-randomised, parallel, double-blind, single-centre, placebo-controlled superiority study (ISRCTN12562026, funded by Cultech Ltd), 220 Bulgarian participants (30 to 65 years old) with BMI 25-34.9 kg/m 2 received Lab4P probiotic (50 billion/day) or a matched placebo for 6 months. Participants maintained their normal diet and lifestyle. primary outcomes were changes in body weight, BMi, waist circumference (WC), waist-to-height ratio (WtHR), blood pressure and plasma lipids. Secondary outcomes were changes in plasma C-reactive protein (CRP), the diversity of the faecal microbiota, quality of life (QoL) assessments and the incidence of upper respiratory tract infection (URTI). Significant between group decreases in body weight (1.3 kg, p < 0.0001), BMI (0.045 kg/m 2 , p < 0.0001), WC (0.94 cm, p < 0.0001) and WtHR (0.006, p < 0.0001) were in favour of the probiotic. Stratification identified greater body weight reductions in overweight subjects (1.88%, p < 0.0001) and in females (1.62%, p = 0.0005). Greatest weight losses were among probiotic hypercholesterolaemic participants (−2.5%, p < 0.0001) alongside a significant between group reduction in small dense LDL-cholesterol (0.2 mmol/L, p = 0.0241). Improvements in QoL and the incidence rate ratio of URTI (0.60, p < 0.0001) were recorded for the probiotic group. No adverse events were recorded. Six months supplementation with Lab4P probiotic resulted in significant weight reduction and improved small dense low-density lipoprotein-cholesterol (sdLDL-C) profiles, QoL and URTI incidence outcomes in overweight/obese individuals. World Health Organisation (WHO) global estimates indicate that 39% of adults are overweight and 13% are obese and trends suggest that levels will continue to rise as a result of current dietary habits and sedentary lifestyles 1. The burden of obesity on primary healthcare providers is substantial and it is estimated that, in England alone in 2013, excess body weight in women cost £2.2 billion in consultations and £1.9 billion for prescription medications 2. One of the consequences of obesity is the increased incidence of Metabolic Syndrome (MetS)-an umbrella term used for a cluster of interrelated metabolic conditions linked with obesity including hypercholesterolaemia,

show abstract

Section: Discussionmentioning

confidence: 99%

A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being

Michael

Jack

Masetti

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The evidence has been confirmed elsewhere ( 38 , 39 ). Accordingly, Maccioni et al ( 40 ) recruited 1455 individuals aged 18–70 in a cross-sectional study on airway infection in Germany. The study reported that obese persons have a consistently higher frequency of upper and lower respiratory tract infections (RTIs).…”

Section: Discussionmentioning

confidence: 99%

Relation of Dietary Factors with Infection and Mortality Rates of COVID-19 across the World

Abdulah

Hassan

2020

The Journal of nutrition, health and aging

View full text Add to dashboard Cite

Objective Poor dietary habits are considered to be the second-leading risk factors for mortality and disability-adjusted life-years (DALYs) in the world. Dietary patterns are different based on cultural, environmental, technological, and economic factors. Nutritional deficiencies of energy, protein, and specific micronutrients have been shown to contribute to depressed immune function and increased susceptibility to infections. We aimed to explore the relation of dietary factors with global infection and mortality rates of COVID-19 in this study. Design In the current ecological study, the countries that had national dietary data from the Global Dietary Databases of the United Nations and Coronavirus disease statistics from the World Health Organization (WHO) were included. The countries that had Coronavirus disease statistics from the WHO were consecutively checked for the recent data of the dietary factors. Setting World. Participants 158 countries across the world. Measurements infection and mortality rates of COVID-19; dietary factors. Results The median crude infection and mortality rates by COVID-19 were 87.78 (IQR: 468.03) and 0.0015 (IQR: 0.0059), respectively. The two highest percentage of the crude infection rate were between 0 and 500 (75.9%) and 500–1000 (8.9%) per one million persons. The regression analysis showed that the crude infection rate has been increased by raising consuming fruits (Beta: 0.237; P=0.006) and calcium (Beta: 0.286; P=0.007) and was decreased with rising consuming beans and legumes (Beta: −0.145; P=0.038). The analysis showed that the crude mortality rate was increased by raising consuming sugar-sweetened beverages (Beta: 0.340; P<0.001). Whereas, the crude mortality rate by COVID-19 has been decreased by increasing fruits consuming (Beta: −0.226; P=0.047) and beans and legumes (Beta: −0.176; P=0.046). Conclusion The present study showed the higher intake of fruits and sugar-sweetened beverages had a positive effect on infection and mortally rates by COVID-19, respectively. In contrast, the higher intake of beans and legumes had a negative effect on both increasing infection and mortality rates.

show abstract

“…Obesity contributes to worse disease outcome in viral infections. Obesity has been found to be associated with increased frequency of both upper respiratory tract infections (adjusted OR 1.55) and lower respiratory tract infections (adjusted OR 2.02) 45 . In a mouse model, when diet‐induced obese (DIO) mice and lean mice were infected with mouse‐adapted influenza virus, the DIO mice had greater mortality than the lean mice (42% vs 5.5%) 46 .…”

Section: Obesity and Respiratory Virusesmentioning

confidence: 99%

Obesity: A critical risk factor in the COVID‐19 pandemic

et al. 2020

View full text Add to dashboard Cite

Summary Obesity is an emerging independent risk factor for susceptibility to and severity of coronavirus disease 2019 (COVID‐19) caused by the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). Previous viral pandemics have shown that obesity, particularly severe obesity (BMI > 40 kg/m2), is associated with increased risk of hospitalization, critical care admission and fatalities. In this narrative review, we examine emerging evidence of the influence of obesity on COVID‐19, the challenges to clinical management from pulmonary, endocrine and immune dysfunctions in individuals with obesity and identify potential areas for further research. We recommend that people with severe obesity be deemed a vulnerable group for COVID‐19; clinical trials of pharmacotherapeutics, immunotherapies and vaccination should prioritize inclusion of people with obesity.

show abstract

Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study

Cited by 64 publications

References 35 publications

A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being

A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being

Relation of Dietary Factors with Infection and Mortality Rates of COVID-19 across the World

Obesity: A critical risk factor in the COVID‐19 pandemic

Contact Info

Product

Resources

About