Obesity and Systemic Oxidative Stress

Keaney, John F.; Larson, Martin G.; Vasan, Ramachandran S.; Wilson, Peter W.F.; Lipinska, Izabella; Corey, Diane; Massaro, Joseph M.; Sutherland, Patrice; Vita, Joseph A.; Benjamin, Emelia J.

doi:10.1161/01.atv.0000058402.34138.11

Cited by 1,169 publications

(323 citation statements)

References 43 publications

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“…A similar difference between age groups applies to NY. The present results are consistent with the findings of the Framingham Heart Study, in which urinary concentrations of the oxidative marker 8-isoprostane were found to decrease with age, suggesting that LP is not a significant feature of normal ageing (37). Due to the selection of study cohort in the present study, the cohort age represented a relative narrow range and this may limit the application of the present results to a wider population.…”

Section: Discussionsupporting

confidence: 87%

“…According to previous results, obesity is a state of chronic increased OS and inflammation (37); therefore, we expected to observe a positive correlation and an increased LP in the overweight and obese group. However, the present results were contrary to our …”

Section: Discussionmentioning

confidence: 62%

“…Increased levels of oxidative damage were expected to be associated with ageing and maternal weight, on the basis of previously reported associations (34)(35)(36)(37)(38)(39). However, no correlation was detected between maternal age and the levels of HEL, DiY and NY.…”

Section: Discussionmentioning

confidence: 93%

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Lipid-lysine adducts and modified tyrosines as markers of oxidative stress in the second trimester of pregnancy and their association with infant characteristics

Rejc

Kato

Karas-Kuzelicki

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Pregnancy is a physiological state accompanied by excessive levels of oxidative stress (OS), due to the increased demand and utilisation of oxygen. There is increasing evidence that maternally augmented OS exerts an adverse effect on pregnancy outcome. The aim of the present prospective study was to determine the association between the urinary concentration of relatively novel OS markers measured in the second trimester of pregnancy and the infant characteristics at birth. The maternal levels of urinary hexanoyl-lysine (HEL), propanoyl-lysine (PRL), dityrosine (DiY) and 3-nitrotyrosine (NY) were evaluated in generally healthy pregnant subjects to determine their association with birth weight, gestation at delivery and Apgar score. The observed levels of the markers were in agreement with those measured in healthy non-pregnant subjects in a previous study. A positive correlation was detected between HEL and PRL, as well as between HEL and DiY. Although the absence of a correlation between NY and the other markers has been previously noted in a non-pregnant population, a positive correlation in the pair PRL-NY (r=0.367; P<0.001) was observed in the present study. Maternal cigarette smoking was associated with increased urinary PRL levels (P=0.034). The most notable observation in the present study was that high levels of PRL and NY were associated with low Apgar scores at 1 and 5 min after birth (OR, 1.098 and 2.084 for PRL and NY, respectively; P<0.05). However, poor predictive accuracy was shown. For NY, the following results were obtained: Area under the curve (AUC), 0.818; sensitivity, 100%; specificity, 57%; positive predictive value (PPV), 11.54%; and negative predictive value (NPV), 100%.For PLR the values were as follows: AUC, 0.802; sensitivity, 100%; specificity, 62.6%; PPV, 13.05%; and NPV, 100%. DiY was negatively associated with preterm birth risk (OR=0.703; P=0.028). In conclusion, the results of the present study indicated the presence of OS in the second trimester of pregnancy, which was detected with damage to lipids and proteins and associated with an adverse Apgar score; however, the selected urinary markers exhibited poor positive predictive efficacy.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 62%

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Lipid-lysine adducts and modified tyrosines as markers of oxidative stress in the second trimester of pregnancy and their association with infant characteristics

Rejc

Kato

Karas-Kuzelicki

et al. 2016

Experimental and Therapeutic Medicine

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“…Elevations of IsoPs in human body fluids and tissues have been found in a diverse array of human disorders, including atherosclerosis (19,20), diabetes (21), obesity (22), cigarette smoking (23), neurodegenerative diseases (24), and many others. Further, treatments for some of these conditions, including antioxidant supplementation, antidiabetic treatments, cessation of smoking, and even weight loss, have been shown to decrease production of F 2 -IsoPs (25,26).…”

Section: F 2 -Isops As Index Of Oxidative Stress In Vivomentioning

confidence: 99%

Human Biochemistry of the Isoprostane Pathway

Milne

Yin

Morrow

2008

Journal of Biological Chemistry

183

134

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“…Further, green tea has potent antioxidant effects that are protective against oxidative stress, a condition that is increasingly recognized as a key mediator of many chronic diseases, including cancer and cardiovascular disease [22]. Green tea contains high quantities of several polyphenols, such as epicatechin, epicatechin gallate, epigallocatechin, and the most pharmacologically potent, EGCG.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Metabolism-Boosting Beverages on 24-hr Energy Expenditure

Davis¹,

Coleman²,

Andersen³

2008

TONUTRJ

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Abstract:The effect of thermogenic meal replacement beverages (TMRB) containing 90 mg EGCG and 100 mg of caffeine on resting energy expenditure (REE) was tested. Thirty adults (19 women, 11 men) were stratified into 3 groups: lean (n=10, BMI 21.5 ± 2.1); overweight/obese (OW) (n=10, BMI 29.8 ± 2.7); or weight maintainers (WM) (n=10, BMI 28.8 ± 4.0). Following an overnight fast, baseline measurements, including REE via indirect calorimetry, were performed. REE was repeated at 30, 60, 90, and 120 minutes after consuming a TMRB. Appetite was assessed via visual analogue scale at baseline, 30 minutes and 120 minutes after the TMRB. Mean 24-hour REE was increased 5.9 ± 2.5% overall (p=0.000), 5.7 ± 3.1% among lean subjects (p=0.0002), 5.3 ± 1.4% among OW subjects (p=0.000), and 6.8 ± 2.7% among WM (p=0.0007). Appetite was significantly reduced 30 minutes after the TMRB (p=0.0002). TMRB appear to be a promising weight control tool.

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Obesity and Systemic Oxidative Stress

Cited by 1,169 publications

References 43 publications

Lipid-lysine adducts and modified tyrosines as markers of oxidative stress in the second trimester of pregnancy and their association with infant characteristics

Lipid-lysine adducts and modified tyrosines as markers of oxidative stress in the second trimester of pregnancy and their association with infant characteristics

Human Biochemistry of the Isoprostane Pathway

The Effect of Metabolism-Boosting Beverages on 24-hr Energy Expenditure

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