Obesity and target organ damage: the kidney

Jong, PE de; Verhave, J.C.; Pinto-Sietsma, SJ; Hillege, HL

doi:10.1038/sj.ijo.0802213

Cited by 191 publications

(133 citation statements)

References 21 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have shown that obesity is associated with MA. 22,[27][28][29] However, in our study, WC and abdominal obesity had a significant association with MA whereas BMI had not. Similarly, several studies have suggested a differential effect according to body morphology.…”

Section: Discussioncontrasting

confidence: 70%

Abdominal obesity, systolic blood pressure, and microalbuminuria in normotensive and euglycemic Korean men

et al. 2006

View full text Add to dashboard Cite

Objectives: To evaluate the relationship between abdominal obesity and microalbuminuria (MA) in normotensive, euglycemic Korean men. Design: A cross-sectional study at a health screening center. Subjects: A total of 1321 healthy, normotensive Korean men, aged 20-78 years, with a fasting plasma glucose level o100 mg/dl. Measurements: Height, weight, and waist; systolic blood pressure (SBP); diastolic blood pressures (DBP); urinary albumin to creatinine ratio (ACR); fasting glucose, insulin, lipids, C-reactive protein (CRP), and white blood cell count. Waist circumference (WC) was used to indicate abdominal obesity and a single measurement of ACR was used to estimate MA. We also calculated body mass index (BMI) based on weight and height. Results: Mean BMI, WC, and SBP were significantly higher in subjects with MA than in those without (24.874.1 vs 23.872.7 kg/m 2 , 8679 vs 8378 cm, and 11575 vs 11277 mmHg, respectively). Multiple logistic regression analyses showed that only WC and SBP were independent predictors of MA. Conclusion: WC and SBP were positively associated with MA in normotensive and euglycemic Korean men.

show abstract

Section: Discussioncontrasting

confidence: 70%

Abdominal obesity, systolic blood pressure, and microalbuminuria in normotensive and euglycemic Korean men

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Indeed, the frequency of microalbuminuria in the general population has been shown to increase with the degree of obesity. 29 Its frequency was significantly higher in subjects with MS than in those without MS suggesting that in children, as in adults, 30 microalbuminuria is associated with MS. Obese children with MS also had higher concentrations of PAI-1 and uric acid which together with microalbuminuria explained 10.6% of the variance of the MS. This proportion is similar to the 7.4% of the total variance of MS explained by an 'inflammatory factor' in nondiabetic individuals participating in the Insulin Resistance Atherosclerosis Study.…”

Section: Discussionmentioning

confidence: 93%

Metabolic syndrome in obese Caucasian children: prevalence using WHO-derived criteria and association with nontraditional cardiovascular risk factors

et al. 2006

View full text Add to dashboard Cite

Objective: Studies on the prevalence of metabolic syndrome (MS) in European obese children using child-based criteria are scanty. Moreover, it is unknown if nontraditional cardiovascular disease (CVD) risk factors are associated with the MS at this early age in these subjects. Design and subjects: We studied the prevalence of the MS in 588 Caucasian obese children and adolescents by devising a World Health Organization derived definition and child-specific criteria, whose deviation from normalcy was based on an age, sex, and ethnically comparable control group of 1363 subjects. In a subgroup of 206 obese children, we investigated the association of the MS with nontraditional CVD risk factors. Measurements: Fasting blood samples for glucose and lipids measurements were taken in both control and obese children. In addition, the obese children underwent an oral glucose tolerance test. In the subgroup of 206 obese children, albumin excretion rate , plasma uric acid, fibrinogen, plasminogen activator inhibitor type 1(PAI-1), C-reactive protein, interleukin 6 and white blood cells were also measured. Results: The prevalence of MS was 23.3%. A similar prevalence of 23% of MS was recorded in the subgroup of 206 obese children in whom measurements of nontraditional CVD risk factors were available. After adjustment for the degree of obesity, subjects with MS had significantly higher uric acid (6.670.23 vs 6.170.12 mg/dl, Po0.0001) and PAI-1 plasma concentrations (231.4725.50 vs 214.3712.96 ng/ml, Po0.05) and a higher frequency of microalbuminuria (37 vs 20%, Po0.05) than those without MS. Microalbuminuria, uric acid and PAI-1 explained 10.6% of the variance of MS. Conclusion: Approximately, a quarter of Caucasian obese children have the MS. The association of MS with several nontraditional risk factors for CVD early in life suggests a heightened CVD risk in these individuals.

show abstract

“…20,41 Obesity, itself, contributes to the development and progression of CKD, independent of elevated BP or diabetes. 42 The risk for end-stage renal disease is progressively higher at increasing BMI levels and in extremely obese individuals in which such risk is much higher than that in persons with normal BMI. 41 Elevated sympathetic nervous activity has been observed in patients with CKD, regardless of obesity, hypertension or diabetes.…”

Section: Discussionmentioning

confidence: 99%

Effects of weight loss on renal function in overweight Japanese men

et al. 2011

View full text Add to dashboard Cite

Obesity is known as an independent risk factor for renal injury. Sympathetic nerve activation may have an important role of the pathogenesis of obesity, and hypertension may underpin the development of cardiovascular events. In the present study, we evaluated the effects of weight loss (WL) on renal function, especially focusing on sympathetic nervous activity. In 154 overweight or obese Japanese men (89 normotensive and 65 untreated mild hypertensive subjects), body weight, body mass index (BMI), total body fat mass, blood pressure (BP), serum creatinine, blood urea nitrogen, creatinine clearance (CCr) (calculated with the Cockcroft-Gault equation) and plasma norepinephrine (NE) were measured before and after a 12-month period of WL with a mild caloric-restricted diet and exercise. A significant WL was defined as 10% or more WL compared with the entry period. In total, 97 (63.0%) subjects succeeded in significant (by 14.3%) WL at 12 months, and 57 subjects (37.0%) did not succeed in significant WL but they lost 7.7% weight. At entry, levels of plasma NE, serum creatinine and fat mass were significantly lower and CCr was greater in the group with a significant WL compared with those without WL. BMI, total body fat mass and plasma NE significantly decreased, and CCr increased with WL. At both baseline and at the 12-month period, fat mass and plasma NE negatively correlated with CCr and positively correlated with creatinine at each time point. Changes in fat mass and plasma NE over 12 months correlated with changes in creatinine, and only changes in fat mass negatively correlated with changes in CCr. Basal fat mass and plasma NE correlated positively with serum creatinine at 12 months and negatively with CCr at the same time point. In multiple regression analyses, basal plasma NE and fat mass were significant determinants of serum creatinine levels and CCr at 12 months.In conclusion, WL improved renal function (as evident from measures of creatinine and CCr) in overweight individuals. Basal plasma NE levels and total body fat mass could be predictors for improvement in renal function associated with WL. Suppression of sympathetic nervous activation associated with WL may have a role in the ameliorative effects on renal function.

show abstract

Obesity and target organ damage: the kidney

Cited by 191 publications

References 21 publications

Abdominal obesity, systolic blood pressure, and microalbuminuria in normotensive and euglycemic Korean men

Abdominal obesity, systolic blood pressure, and microalbuminuria in normotensive and euglycemic Korean men

Metabolic syndrome in obese Caucasian children: prevalence using WHO-derived criteria and association with nontraditional cardiovascular risk factors

Effects of weight loss on renal function in overweight Japanese men

Contact Info

Product

Resources

About