Obesity and testicular function

Mah, Peak Mann; Wittert, Gary

doi:10.1016/j.mce.2009.06.007

Cited by 152 publications

(106 citation statements)

References 95 publications

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“…The non-significant trend for oestradiol serum level to increase with growing weight was also visible in our study. This phenomenon may result in a greater degree of testosterone deficiency by acting at the hypothalamus to decrease GnRH pulse frequency, at the pituitary to decrease LH secretion, and at the testicular level to inhibit testosterone biosynthesis [37,38]. It has been found that oestradiol serum levels show a positive cross-sectional relationship with age and depressed mood related to declining sexual function in ageing men [39].…”

Section: Sexual Fantasiesmentioning

confidence: 99%

Zależność pomiędzy funkcją seksualną a wskaźnikiem masy ciała i stężeniem hormonów steroidowych u młodych mężczyzn

Jastrzebska¹,

Walczak-Jędrzejowska²,

Kramek³

et al. 2014

Endokrynologia Polska

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Introduction: In older men, sexual disorders may be the result of a decrease in testosterone and an increase in sex hormone binding globulin (SHBG) serum levels. Although obesity may enhance the decline of testosterone, it is also the cause of metabolic disorders, which are additional risk factors of erectile dysfunction. The purpose of this study was to investigate whether elevated body weight is associated with decreased serum testosterone concentrations and reduced sexual function in young men. Material and methods: Data on general health, medication, depressive symptomatology and sexual life was obtained from 136 men aged 20-49 years. Blood levels of LH, total testosterone (TT), dehydroepiandrosterone sulfate (DHEA-S), oestradiol, SHBG, total cholesterol, LDL-and HDL-cholesterol, and triglycerides were determined. Body mass index (BMI), waist to hip ratio (WHR) and free testosterone index (FTI) were calculated. Results: A significantly reduced occurrence of sexual fantasies, morning erections and erectile function scores was observed in the oldest group compared to the youngest men with normal BMI, although orgasmic function was unchanged. A significant decrease in TT serum levels was observed in obese 30-year-olds compared to men with normal BMI, while in obese 40-year-olds decreased LH and SHBG levels were also found. No differences in the levels of lipids and sexual achievements were found among men with different BMI. However, erectile function and morning erections significantly negatively correlated with age, BMI and WHR, and positively with FTI, but not with other studied hormones and lipids.

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Section: Sexual Fantasiesmentioning

confidence: 99%

Zależność pomiędzy funkcją seksualną a wskaźnikiem masy ciała i stężeniem hormonów steroidowych u młodych mężczyzn

Jastrzebska¹,

Walczak-Jędrzejowska²,

Kramek³

et al. 2014

Endokrynologia Polska

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“…Rather than the dubious pursuit of pathologizing of ageing, the evaluation of whether testosterone may have a role in adjunctive treatment of obesity, diabetes, metabolic syndrome or other chronic nongonadal diseases by rigorous interventional studies featuring randomisation and placebo controls, appear justified by a variety of observational studies. [49][50][51] In their wider impact, these two studies can be construed as pressing the accelerator and the brakes at the same time on testosterone prescribing for older men... with probably the same effect of spinning wheels without moving forward. 52 The challenge remains whether we can break free from the seemingly irresistible pull into a familiar downward spiral to learn from history rather than blindly repeating it.…”

Section: Reflectionsmentioning

confidence: 99%

An old emperor finds new clothing: rejuvenation in our time

Handelsman

2010

Asian J Androl

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“…Likewise, many diabetic men are known to have hypothalamic-pituitary-testicular axis disturbances (e.g., a reduction in testosterone) and to be infertile. 89,90 Furthermore, it comes as little surprise that obesity, which in and of itself is a risk factor for diabetes, cancer, infertility and a host of other morbidities, has also been linked to environmental toxicant exposure. Today, obesity is a serious public health concern as more than 30% of Americans are obese; and while over-eating, inactivity and genetic predisposition are major contributors of the obesity crisis, environmental toxicant exposure is probably also a contributing factor.…”

confidence: 99%

Environmental contaminants

Mruk

Cheng

2011

Spermatogenesis

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C ontaminants such as cadmium, bisphenol A and lead pollute our environment and affect male reproductive function. There is evidence that toxicant exposure adversely affects fertility. Cadmium and bisphenol A exert their effects in the testis by perturbing bloodtestis barrier function, which in turn affects germ cell adhesion in the seminiferous epithelium because of a disruption of the functional axis between these sites. In essence, cadmium mediates its adverse effects at the blood-testis barrier by disrupting cell adhesion protein complexes, illustrating that toxicants can dismantle cell junctions in the testis. Herein, we will discuss how environmental toxicants may affect reproductive function. We will also examine how these adverse effects on fertility may be mediated in part by adipose tissue and bone. Lastly, we will briefly discuss how toxicantinduced damage may be effectively managed so that fertility can be maintained. It is hoped that this information will offer a new paradigm for future studies.

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Obesity and testicular function

Cited by 152 publications

References 95 publications

Zależność pomiędzy funkcją seksualną a wskaźnikiem masy ciała i stężeniem hormonów steroidowych u młodych mężczyzn

Zależność pomiędzy funkcją seksualną a wskaźnikiem masy ciała i stężeniem hormonów steroidowych u młodych mężczyzn

An old emperor finds new clothing: rejuvenation in our time

Environmental contaminants

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