Obesity and the Endocrine System, Part I: Pathogenesis of Weight Gain in Endocrine and Metabolic Disorders

Freemark, Michael

doi:10.1007/978-3-319-68192-4_19

Cited by 1 publication

(1 citation statement)

References 72 publications

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“…Previous large-scale prospective studies had shown that the TC/HDL-C ratio can be a reliable predictor of coronary heart disease and death [6-8]. Meanwhile, insulin resistance is accompanied by excessive production of VLDL-C from the liver and chemical transformation of HDL particles resulting in more rapid excretion from the kidneys, resulting in changes in lipid profiles such as elevation of TG and a decrease in HDL-C [9]. In this context, TG/HDL-C ratio has been shown to be directly associated with insulin resistance and cardiovascular events in adults [10,11], and has also been demonstrated to be related to insulin resistance and carotid artery intima-media thickness in both adults and children [12,13].…”

Section: Introductionmentioning

confidence: 99%

Risk assessment of metabolic syndrome in adolescents using the triglyceride/high-density lipoprotein cholesterol ratio and the total cholesterol/high-density lipoprotein cholesterol ratio

Chu

Jung

Park

et al. 2019

Ann Pediatr Endocrinol Metab

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Purpose This study was conducted to investigate the distributions of the triglyceride (TG) to high-density lipoprotein-cholesterol (HDL-C) ratio and total cholesterol (TC) to HDL-C ratio, and to explore their usefulness as markers of metabolic syndrome (MetS) in Korean adolescents. Methods We obtained data for 2,721 adolescents (1,436 boys and 1,285 girls) aged 10–18 years who participated in the Korean National Health and Nutrition Examination Surveys from 2008 to 2010. International Diabetes Federation criteria were used to define MetS. Results There were no significant gender-related differences in TG/HDL-C or TC/HDL-C ratios. These lipid ratios showed significant associations with homeostatic model assessment for insulin resistance (HOMA-IR) and waist circumference. Areas under the receiver operating characteristic curve to identify MetS were 0.947 for TG/HDL-C and 0.924 for TC/HDL-C, which were higher than that of HOMA-IR (0.822). Optimal cutoff values (sensitivity, specificity) of TG/HDL-C and TC/HDL-C ratios for MetS prediction were 3.3 (85.7%, 89.9%), and 3.8 (92.9%, 82.8%), respectively. Odds ratio (OR; 95% confidence intervals [CIs]) for MetS in adolescents with TC/HDL-C ratio above the cutoff value was 14.8 (2.8–77.4), while that for TG/HDL-C ratio about the cutoff value was 30.6 (6.0–157.6). In adolescents who had both lipid ratios above the cutoff values, the OR (95% CI) for MetS was 36.2 (7.2–186.2). Conclusion TG/HDL-C and TC/HDL-C ratios are useful markers of metabolic syndrome with high predictive value in Korean adolescents.

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