Obesity and the lungs: Not just a crush

King, Gregory G.; Thamrin, Cindy

doi:10.1111/resp.13532

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…The increased need for intubation in our study may have been due to the high prevalence of obesity in the study population, as a high BMI is associated with poor respiratory function. [18][19][20] ARDS, a complication of COVID-19, 21,22 was present in 30% of the patients. One of the mechanisms proposed in the development of this complication is diffuse alveolar damage associated with the development of microthrombosis and endothelial cell damage.…”

Section: Discussionmentioning

confidence: 98%

Factors associated with survival in patients with COVID -19 admitted to a community hospital in New York City

Singh¹,

Shady²,

Gbaje³

et al. 2021

JLPRR

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Introduction: COVID-19 has been associated with increased mortality in old age, hypertension and male gender. Higher prevalence of increased body mass index (BMI), mechanical ventilation and renal failure has been found in the patients admitted to our New York City community hospital; accordingly we aim to explore the association between these parameters and survival in our patients. Methods: Retrospective review of patients admitted with the COVID-19 disease March 14 to April 30 of 2020. Analysis using Cox regression models, Log rank tests and Kaplan Meier curves was done for a total of 326 patients that met our criteria. Results: The adjusted odds of death for those at least 75 years of age were higher than those within the age group of 18 to 44 years. The patients with over 92% oxygen saturation had lower adjusted odds of death than those with 88 to 92% oxygen saturation (Odds Ratio (OR)=0.2, 95% CI=0.06, 0.70), as well as lower adjusted hazard of dying (Hazard Ratio (HR)=0.4, 95% CI=0.21, 0.87). Intubation was associated with a higher adjusted odds ratio (OR=57.8, 95% CI=17.74, 188.30) and adjusted hazard ratio HR=5.4 (95% CI=2.59, 11.21) for death. After controlling for age and gender, neither levels of serum D-dimer nor creatinine were found to be significantly associated with mortality The factors that comprise metabolic syndrome, i.e., elevated BMI, diabetes, hypertension, and hyperlipidemia, were found to have no significant association with the outcome of death after controlling for age and sex and they also had no significant association with the time until death. Conclusions: In the study population, COVID-19 was associated with increased mortality in patients who required intubation, and in the elderly, which may be explained by changes in the immune system over time. Elevated BMI, though not statistically significant, was present in the majority of our study population, which may have contributed to the group's high mortality.

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Section: Discussionmentioning

confidence: 98%

Factors associated with survival in patients with COVID -19 admitted to a community hospital in New York City

Singh¹,

Shady²,

Gbaje³

et al. 2021

JLPRR

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Transmedia Western: Lucasfilm, Genre Linking and The Mandalorian

Freeman

Smith²

2023

Transmedia/Genre

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Six-Minute Walk Test among obese and nonobese subjects: A comparative analysis among apparently healthy volunteers

Ghosh,

Shinde,

Kawale

et al. 2024

Ann Med Sci Res

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Context: The Six-Minute Walk Test (6MWT) is a simple measure for objective assessment of physical fitness and exercise tolerance. It has also been standardized to follow up on the prognosis and progression of chronic cardiovascular and respiratory diseases. Though there are standardized formulas for analyzing the 6MWT results concerning age, height, weight, regional, and ethnic population these should be revisited considering the wider variations of subjects in the reference studies. Aim: This article aims to compare the 6MWT performance among obese and nonobese, apparently healthy volunteers. Settings and Design: A cross-sectional study was conducted in the Physiology Department, AIIMS Kalyani, West Bengal, India. Materials and Methods: Age and sex-matched apparently healthy volunteers were included in the study after their consent. After collection of anthropometric data, they were divided into two groups; group A with body mass index (BMI) <30 kg/m2 and group B with BMI >30 kg/m2. The 6MWT was implemented according to standard guidelines; the Six-Minute Walk Distance (6MWD) and other parameters were noted. Statistical analysis was performed by Statistical Package for the Social Sciences software version 17 (IBM Corp., Chicago, IL, USA). Results: The results revealed that a comparison was done between actual values and predicted values of 6MWD. Among obese groups, the actual 6MWD covered was significantly lesser than the predicted values. Significant differences were also found between the two groups concerning Borg score, Calculated volume of oxygen max, systolic and diastolic blood pressures, respiratory rate, heart rate, and Peripheral capillary oxygen saturation. Conclusions: The results revealed that our result shows that the weight-based reference equation for interpretation of 6MWT may not be sufficient for obese subjects.

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Obesity and the lungs: Not just a crush

Abstract: See related https://onlinelibrary.wiley.com/doi/10.1111/resp.13478

Cited by 3 publications

References 14 publications

Factors associated with survival in patients with COVID -19 admitted to a community hospital in New York City

Factors associated with survival in patients with COVID -19 admitted to a community hospital in New York City

Transmedia Western: Lucasfilm, Genre Linking and The Mandalorian

Six-Minute Walk Test among obese and nonobese subjects: A comparative analysis among apparently healthy volunteers

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