Obesity and the risk of primary liver cancer: A systematic review and meta-analysis

Abstract

Background/Aims: In this systematic review and meta-analysis, we aimed to clarify the effect of obesity on the occurrence of and mortality from primary liver cancer. Methods: This study was conducted using a systematic literature search of MEDLINE, EMBASE, and the Cochrane Library until November 2018 using the primary keywords "obesity," "overweight," "body mass index (BMI)," "body weight," "liver," "cancer," "hepatocellular carcinoma," "liver cancer," "risk," and "mortality." Studies assessing the relationship between BMI and occurrence of or mortality from primary liver cancer in prospective cohorts and those reporting hazard ratios (HRs) or data that allow HR estimation were included. Results: A total of 28 prospective cohort studies with 8,135,906 subjects were included in the final analysis. These included 22 studies with 6,059,561 subjects for cancer occurrence and seven studies with 2,077,425 subjects for cancerrelated mortality. In the meta-analysis, an increase in BMI was associated with the occurrence of primary liver cancer (HR, 1.69; 95% confidence interval, 1.50-1.90, I 2 =56%). A BMI-dependent increase in the risk of occurrence of primary liver cancer was reported. HRs were 1.36 (95% CI, 1.02-1.81), 1.77 (95% CI, 1.56-2.01), and 3.08 (95% CI, 1.21-7.86) for BMI >25 kg/m 2 , >30 kg/m 2 , and >35 kg/m 2 , respectively. Furthermore, increased BMI resulted in enhanced liver cancer-related mortality (HR, 1.61; 95% CI, 1.14-2.27, I 2 =80%). Conclusions: High BMI increases liver cancer mortality and occurrence of primary liver cancer. Obesity is an independent risk factor for the occurrence of and mortality from primary liver cancer. Clin Mol Hepatol 2020 Nov 26.

NAFLD-driven HCC: Safety and efficacy of current and emerging treatment options

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Metformin and Dichloroacetate Suppress Proliferation of Liver Cancer Cells by Inhibiting mTOR Complex 1

“…Recently, it was emphasized that magnetic resonance imaging (MRI) can be helpful to detect HCC within early stages [ 4 , 5 , 6 , 7 , 8 , 9 ]. Particularly, in obese or cirrhotic patients, sensitivity of ultrasound (US) for detection of HCC within early stages can be problematic due to poor sonic window [ 6 , 10 , 11 , 12 , 13 , 14 , 15 ]. However, in real field, US exams are the main surveillance tool because of unsolved medical insurance problems for high cost MRI.…”

Obesity and Its Relationship With Cancer: Part Iii

“…Obesity is an independent risk factor for the occurrence of HCC 103 . Sohn et al reported that their study revealed that the risk of occurrence of primary liver cancer was increased in patients with excess body weight, with pooled hazard ratio of 1.36, 1.77, and 3.08 for a BMI >25, >30, and >35 kg/m2, respectively (Sohn et al, 2021). They also found that the risk of mortality from primary liver cancer increased as the BMI increased >25 kg/m 2 .…”