Obesity and the Risk of Cryptogenic Ischemic Stroke in Young Adults

Jaakonmäki, Nina; Zedde, Marialuisa; Sarkanen, Tomi; Martinez‐Majander, Nicolas; Tuohinen, Suvi; Sinisalo, Juha; Ryödi, Essi; Autere, Jaana; Hedman, Marja; Junttola, Ulla; Huhtakangas, Jaana K.; Capitello, Teresa Grimaldi; Pascarella, Rosario; Nordanstig, Annika; Bech‐Hanssen, Odd; Holbe, Christine; Busch, Rainer; Fromm, Annette; Ylikotila, Pauli; Turgut, Esme Ekizoğlu; Amorim, Isabel R.; Ryliškienė, Kristina; Tulkki, Lauri; Pascasio, Laura Amaya; Líčeník, Radim; Ferdinand, Phillip; Tsivgoulis, Georgios; Jatužis, Dalius; Kõrv, Liisa; Kõrv, Janika; Pezzini, Alessandro; Fonseca, Ana Catarina; Yeşilot, Nilüfer; Roine, Risto O.; Waje‐Andreassen, Ulrike; Sarnowski, Bettina von; Redfors, Petra; Huhtakangas, Juha; Numminen, Heikki; Jäkälä, Pekka; Putaala, Jukka

doi:10.1016/j.jstrokecerebrovasdis.2022.106380

Cited by 18 publications

(11 citation statements)

References 35 publications

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“…Research conducted in 2021 revealed that patients who had a history of adolescent overweight and obesity as measured by BMI had a higher risk of developing an early-onset ischemic stroke (40). A study on obesity and cryptogenic ischemic stroke found that a high BMI was associated with a higher risk of ischemic stroke in young individuals when smoking, high blood pressure, and diabetes were taken into consideration (41). Our study found the genetic evidence of weight gain after depression may increase the risk of stroke.…”

Section: Discussionmentioning

confidence: 99%

Identification of the putative causal risk factors and biomarkers of stroke using large-scale genome-wide studies

Islam

García-Marín

Rentería

et al. 2023

Preprint

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Stroke is the second leading cause of death and the third leading cause of long-term disability in the world. This study aimed to explore the novel putative causal genetic relationship of stroke with hundreds of complex traits by leveraging genetic data. We used genome-wide association studies (GWAS) data and the latent causal variable method to identify potential causal relationships between stroke and 1,504 complex traits of the UK biobank. We found that 262 traits were genetically correlated with stroke risk at a false discovery rate (FDR <0.05). Of those correlated traits, 28 showed robust evidence of partial genetic causality (GCP) with stroke (|GCP|> 0.60; FDR < 0.05). Our results showed that some conditions, including atrial fibrillation, pulmonary embolism, blood clots in the lung, platelet crit, self-reported deep venous thrombosis, weight gain after depression, and the use of some medications such as insulin, pioglitazone, and gliclazide were inferred to increase stroke risk. On the other hand, greater levels of testosterone, apolipoprotein A, SHBG, and HDL cholesterol decrease the risk of stroke. Also, our results suggest that genetic susceptibility to stroke raises the risk of neck and chest pain and loose teeth. Finally, our findings suggest that cardiac vascular disease, blood clot in lung, deep venous thrombosis, and certain anti-diabetic medications could have a causal role in increasing the risk of stroke, which could be used as novel testable hypotheses for future epidemiological studies.

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Section: Discussionmentioning

confidence: 99%

Identification of the putative causal risk factors and biomarkers of stroke using large-scale genome-wide studies

Islam

García-Marín

Rentería

et al. 2023

Preprint

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“…Md Habib et al 2011 assessed high waist to hip ratio as a risk factor for ischemic stroke for overall stroke and he found 64% of the ischemic stroke patient had abnormal WHR in Bangladesh [ 24 ]. Abdominal obesity measured with WHR was an independent risk factor for cryptogenic ischemic stroke (CIS) in young adults after rigorous adjustment for concomitant risk factors in the Revealing the Etiology, Triggers, and Outcome (SECRETO; NCT01934725) study, a prospective case–control study that included patients aged 18–49 years with a first ever CIS at 19 European university centers [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Stroke in young adults, stroke types and risk factors: a case control study

Namaganda¹,

Nakibuuka

Kaddumukasa

et al. 2022

BMC Neurol

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Background Stroke is the second leading cause of death above the age of 60 years, and the fifth leading cause in people aged 15 to 59 years old as reported by the World Health Organization global burden of diseases. Stroke in the young is particularly tragic because of the potential to create long-term disability, burden on the victims, their families, and the community at large. Despite this, there is limited data on stroke in young adults, and its risk factors in Uganda. Therefore, we determined the frequency and risk factors for stroke among young adults at Mulago hospital. Methods A case control study was conducted among patients presenting consecutively to the general medical wards with stroke during the study period September 2015 to March 2016. A brain Computerized Tomography scan was performed to confirm stroke and classify the stroke subtype. Controls were patients that presented to the surgical outpatient clinic with minor surgical conditions, matched for age and sex. Social demographic, clinical and laboratory characteristics were assessed for both cases and controls. Descriptive statistics including frequencies, percentages, means, and standard deviation were used to describe the social demographics of case and controls as well as the stroke types for cases. To determine risk factors for stroke, a conditional logistic regression, which accounts for matching (e.g., age and sex), was applied. Odds ratio (with 95% confidence interval) was used as a measure for associations. Results Among 51 patients with stroke, 39(76.5%) had ischemic stroke and 12(23.5%) had hemorrhagic stroke. The mean age was 36.8 years (SD 7.4) for stroke patients (cases) and 36.8 years (SD 6.9) for controls. Female patients predominated in both groups 56.9% in cases and 52.9% in controls. Risk factors noted were HIV infection, OR 3.57 (95% CI 1.16–10.96), elevated waist to hip ratio, OR 11.59(95% CI 1.98–68.24) and sickle cell disease, OR 4.68 (95% CI 1.11–19.70). This study found a protective effect of oral contraceptive use for stroke OR 0.27 95% CI 0.08–0.87. There was no association between stroke and hypertension, diabetes, and hyperlipidemia. Conclusion Among young adults with stroke, ischemic stroke predominated over hemorrhagic stroke. Risk factors for stroke were HIV infection, elevated waist to hip ratio and sickle cell disease.

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“…Badania naukowe wskazują na silny związek pomiędzy wzrostem masy ciała i wartości BMI oraz ryzykiem wystąpienia migotania przedsionków, które według danych naukowych aż w 20 % przypadków może być spowodowane otyłością [25]. Zgodnie z wynikami badań otyłość zwiększa podatność mózgu na niedotlenienie i jest uważana za czynnik ryzyka udaru niedokrwiennego mózgu [28], [30]. Co więcej, otyłość jest także czynnikiem ryzyka nawrotu udaru mózgu [29].…”

Section: Implikacje Zdrowotne Nadwagi I Otyłościunclassified

Obesity of children and adults - pandemic of the 21st century

PANASIUK

SZPONAROWICZ

PANEK

et al. 2023

J Educ Health Sport

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Objective: The aim of the study was to draw attention to the problem of overweight and obesity among children and adults. Another important aspect of this article was to indicate the need of promotion a healthy lifestyle as a way to reduce body weight. Methods: Available literature was reviewed for the purpose of writing this article. Using keywords such as obesity, overweight, pandemics, diet, lifestyle, chronic diseases, metabolic disorders- PubMed was searched. Results: The incidence of overweight and obesity is constantly increasing. This phenomenon is observed all over the world. Obesity has become a pandemic of the 21st century. Consumption of unhealthy, highly processed food is increasing these days. In addition, sedentary lifestyle is very popular. Lifestyle and diet changes are the main causes of this pandemic. The SARS-CoV-2 virus also had an impact on the development of the obesity and overweight pandemic. Obesity affects the quality of life and causes many chronic diseases. The effects on the community are also significant. Obesity and related diseases like diabetes, ischemic heart disease, heart attacks, asthma result in high health care costs. Conclusion: The percentage of overweight and obese people around the world is increasing. It is necessary to promote healthy eating, active lifestyle and look for alternative ways to reduce the scale of overweight and obesity problem.

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Obesity and the Risk of Cryptogenic Ischemic Stroke in Young Adults

Cited by 18 publications

References 35 publications

Identification of the putative causal risk factors and biomarkers of stroke using large-scale genome-wide studies

Identification of the putative causal risk factors and biomarkers of stroke using large-scale genome-wide studies

Stroke in young adults, stroke types and risk factors: a case control study

Obesity of children and adults - pandemic of the 21st century

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