Obesity and Type 2 Diabetes

Khalil, Charbel Abi; Taheri, Shahrad

doi:10.1007/978-3-319-12766-8_12

Cited by 5 publications

(3 citation statements)

References 94 publications

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“…Obesity has reached epidemic proportions around the world [ 1 ]. As the prevalence and incidence of obesity continue to increase, bariatric surgery has become one of the main cornerstones of the treatment [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Diabetes Is Associated with Worse Postoperative Mortality and Morbidity in Bariatric Surgery, Regardless of the Procedure

Khalil,

Dargham,

Jayyousi

et al. 2024

JCM

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Background/Objectives: Bariatric surgery is a central cornerstone in obesity treatment. We aimed to assess the impact of diabetes on the postoperative outcomes of bariatric surgery and compare three techniques: sleeve gastrectomy, Roux-en-Y, and gastric banding. Methods: We extracted data from the National Inpatient Sample (2015–2019) using ICD codes. The primary outcome was postoperative mortality. Secondary outcomes were major bleeding, atrial fibrillation, and acute renal failure. Results: Among patients who underwent sleeve gastrectomy, diabetes was associated with a higher adjusted risk of mortality (aOR 2.07 [1.36–3.16]), atrial fibrillation, and acute renal failure, but a similar risk of bleeding. Among patients who underwent Roux-en-Y, diabetes did not increase mortality and bleeding risk. Still, it was associated with a higher risk of atrial fibrillation and acute renal failure. Among patients who underwent gastric banding, diabetes was only associated with a higher risk of bleeding. When comparing the three techniques in diabetes patients, Roux-en-Y was significantly associated with higher mortality and acute renal failure risk when compared to the other procedures. Bleeding was more common in Roux-en-Y than in Sleeve. Conclusions: In total, diabetes is associated with worse postoperative outcomes in bariatric surgery, regardless of the technique. Among diabetes patients, Roux-en-Y was associated with the highest mortality and morbidity.

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Section: Introductionmentioning

confidence: 99%

Diabetes Is Associated with Worse Postoperative Mortality and Morbidity in Bariatric Surgery, Regardless of the Procedure

Khalil,

Dargham,

Jayyousi

et al. 2024

JCM

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“…Even though MI‐related mortality has decreased over time, the excess mortality associated with diabetes still exists [9]. Obesity increases the risk of T2DM [10]. Nevertheless, an obesity paradox has also been reported in individuals with diabetes, with and without cardiovascular disease [11, 12].…”

Section: Introductionmentioning

confidence: 99%

Overweight and obesity are associated with better survival inSTEMIpatients with diabetes

Chaudhry,

Bodair,

Mahfoud

et al. 2023

Obesity

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ObjectiveThe relationship between obesity and in‐hospital outcomes in individuals with type 2 diabetes mellitus (T2DM) who develop an ST‐elevation myocardial infarction (STEMI) was assessed.MethodsData from the National Inpatient Sample (NIS) from 2008 to 2017 were analyzed. Patients with STEMI and T2DM were classified as being underweight or having normal weight, overweight, obesity, and severe obesity. The temporal trend of those BMI ranges and in‐hospital outcomes among different obesity groups were assessed.ResultsA total of 74,099 patients with T2DM and STEMI were included in this analysis. In 2008, 35.8% of patients had obesity, and 37.3% had severe obesity. However, patients with obesity accounted for most of the study population in 2017 (57.8%). During the observation period, mortality decreased in underweight patients from 18.1% to 13.2% (p < 0.001). Still, it gradually increased in all other BMI ranges, along with cardiogenic shock, atrial fibrillation, and ventricular fibrillation (p < 0.001 for all). After the combination of all patients during the observation period, mortality was lower in patients with overweight and obesity (adjusted odds ratio = 0.625 [95% CI 0.499–0.784]; 0.606 [95% CI 0.502–0.733], respectively).ConclusionsA U‐shaped association governs the relationship between BMI and mortality in STEMI patients with diabetes, with those having overweight and obesity experiencing better survival.

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“…In a large population health study, the global age-standardized diabetes prevalence increased from 4.3% in 1980 to 9.0% in 2014 in men, and from 5.0% to 7.9% in women [1]. Potential causes for the higher incidence of T2D worldwide are increased survival of the elderly as well as epidemic bursts of obesity and sedentary lifestyle at all age ranges [2]. Diabetes is associated with a higher incidence of cardiovascular events, which results in a higher rate of mortality [3].…”

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confidence: 99%